Kidney Drug Transporters in Pharmacotherapy

The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug–drug int...

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Detalles Bibliográficos
Autores principales: Łapczuk-Romańska, Joanna, Droździk, Maria, Oswald, Stefan, Droździk, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917665/
https://www.ncbi.nlm.nih.gov/pubmed/36769175
http://dx.doi.org/10.3390/ijms24032856
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author Łapczuk-Romańska, Joanna
Droździk, Maria
Oswald, Stefan
Droździk, Marek
author_facet Łapczuk-Romańska, Joanna
Droździk, Maria
Oswald, Stefan
Droździk, Marek
author_sort Łapczuk-Romańska, Joanna
collection PubMed
description The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug–drug interactions, as well as constituting direct drug targets. The above aspects of kidney transport proteins are discussed in the review.
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spelling pubmed-99176652023-02-11 Kidney Drug Transporters in Pharmacotherapy Łapczuk-Romańska, Joanna Droździk, Maria Oswald, Stefan Droździk, Marek Int J Mol Sci Review The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug–drug interactions, as well as constituting direct drug targets. The above aspects of kidney transport proteins are discussed in the review. MDPI 2023-02-02 /pmc/articles/PMC9917665/ /pubmed/36769175 http://dx.doi.org/10.3390/ijms24032856 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Łapczuk-Romańska, Joanna
Droździk, Maria
Oswald, Stefan
Droździk, Marek
Kidney Drug Transporters in Pharmacotherapy
title Kidney Drug Transporters in Pharmacotherapy
title_full Kidney Drug Transporters in Pharmacotherapy
title_fullStr Kidney Drug Transporters in Pharmacotherapy
title_full_unstemmed Kidney Drug Transporters in Pharmacotherapy
title_short Kidney Drug Transporters in Pharmacotherapy
title_sort kidney drug transporters in pharmacotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917665/
https://www.ncbi.nlm.nih.gov/pubmed/36769175
http://dx.doi.org/10.3390/ijms24032856
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