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The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria

Imaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The assessment of iodine concentration within a live...

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Autores principales: Reginelli, Alfonso, Del Canto, Mariateresa, Clemente, Alfredo, Gragnano, Eduardo, Cioce, Fabrizio, Urraro, Fabrizio, Martinelli, Erika, Cappabianca, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917684/
https://www.ncbi.nlm.nih.gov/pubmed/36769527
http://dx.doi.org/10.3390/jcm12030879
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author Reginelli, Alfonso
Del Canto, Mariateresa
Clemente, Alfredo
Gragnano, Eduardo
Cioce, Fabrizio
Urraro, Fabrizio
Martinelli, Erika
Cappabianca, Salvatore
author_facet Reginelli, Alfonso
Del Canto, Mariateresa
Clemente, Alfredo
Gragnano, Eduardo
Cioce, Fabrizio
Urraro, Fabrizio
Martinelli, Erika
Cappabianca, Salvatore
author_sort Reginelli, Alfonso
collection PubMed
description Imaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The assessment of iodine concentration within a liver lesion reflects the biological properties of the tumor and provides additional information to radiologists that is normally invisible to the human eye. The possibility to predict tumor aggressiveness and therapeutic response based on quantitative and reproducible parameters obtainable from DECT images could improve clinical decisions and drive oncologists to choose the best therapy according to metastasis biological features. Moreover, in comparison with standard dimensional criteria, DECT provides further data on the cancer microenvironment, especially for patients treated with antiangiogenic-based drugs, in which tumor shrinkage is a late parameter of response. We investigated the predictive role of DECT in the early assessment of liver metastasis response to treatment in comparison with standard dimensional criteria during antiangiogenetic-based therapy.
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spelling pubmed-99176842023-02-11 The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria Reginelli, Alfonso Del Canto, Mariateresa Clemente, Alfredo Gragnano, Eduardo Cioce, Fabrizio Urraro, Fabrizio Martinelli, Erika Cappabianca, Salvatore J Clin Med Article Imaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The assessment of iodine concentration within a liver lesion reflects the biological properties of the tumor and provides additional information to radiologists that is normally invisible to the human eye. The possibility to predict tumor aggressiveness and therapeutic response based on quantitative and reproducible parameters obtainable from DECT images could improve clinical decisions and drive oncologists to choose the best therapy according to metastasis biological features. Moreover, in comparison with standard dimensional criteria, DECT provides further data on the cancer microenvironment, especially for patients treated with antiangiogenic-based drugs, in which tumor shrinkage is a late parameter of response. We investigated the predictive role of DECT in the early assessment of liver metastasis response to treatment in comparison with standard dimensional criteria during antiangiogenetic-based therapy. MDPI 2023-01-22 /pmc/articles/PMC9917684/ /pubmed/36769527 http://dx.doi.org/10.3390/jcm12030879 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Reginelli, Alfonso
Del Canto, Mariateresa
Clemente, Alfredo
Gragnano, Eduardo
Cioce, Fabrizio
Urraro, Fabrizio
Martinelli, Erika
Cappabianca, Salvatore
The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria
title The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria
title_full The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria
title_fullStr The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria
title_full_unstemmed The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria
title_short The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria
title_sort role of dual-energy ct for the assessment of liver metastasis response to treatment: above the recist 1.1 criteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917684/
https://www.ncbi.nlm.nih.gov/pubmed/36769527
http://dx.doi.org/10.3390/jcm12030879
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