Cargando…

Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury

Sphingolipids are exceptionally diverse, comprising hundreds of unique species. The bulk of circulating sphingolipids are synthesized in the liver, thereby plasma sphingolipid profiles represent reliable surrogates of hepatic sphingolipid metabolism and content. As changes in plasma sphingolipid con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gai, Zhibo, Samodelov, Sophia L., Alecu, Irina, Hornemann, Thorsten, Grove, Jane I., Aithal, Guruprasad P., Visentin, Michele, Kullak-Ublick, Gerd A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917723/ https://www.ncbi.nlm.nih.gov/pubmed/36769329 http://dx.doi.org/10.3390/ijms24033013

Ejemplares similares

Molecular Mechanisms of Colistin-Induced Nephrotoxicity
por: Gai, Zhibo, et al.
Publicado: (2019)

Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology
por: Samodelov, Sophia L., et al.
Publicado: (2020)

Renal Reabsorption of Folates: Pharmacological and Toxicological Snapshots
por: Samodelov, Sophia L, et al.
Publicado: (2019)

Renal Glycosuria as a Novel Early Sign of Colistin-Induced Kidney Damage in Mice
por: Samodelov, Sophia L., et al.
Publicado: (2019)

The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity
por: Rausch, Magdalena, et al.
Publicado: (2022)

Altered sphingoid base profiles in type 1 compared to type 2 diabetes
por: Wei, Nancy, et al.
Publicado: (2014)

The Role of Mitochondria in Drug-Induced Kidney Injury
por: Gai, Zhibo, et al.
Publicado: (2020)

Lipid Accumulation and Chronic Kidney Disease
por: Gai, Zhibo, et al.
Publicado: (2019)

Cholesterol stimulates the cellular uptake of L-carnitine by the carnitine/organic cation transporter novel 2 (OCTN2)
por: Zhang, Lu, et al.
Publicado: (2021)

Correlation of the plasma sphingoid base profile with results from oral glucose tolerance tests in gestational diabetes mellitus
por: Khan, Abad, et al.
Publicado: (2017)

The Role of NF-kB in the Downregulation of Organic Cation Transporter 2 Expression and Renal Cation Secretion in Kidney Disease
por: Han, Chao, et al.
Publicado: (2022)

Characterization of ligand-induced thermal stability of the human organic cation transporter 2 (OCT2)
por: Maane, Max, et al.
Publicado: (2023)

The Role of the Carnitine/Organic Cation Transporter Novel 2 in the Clinical Outcome of Patients With Locally Advanced Esophageal Carcinoma Treated With Oxaliplatin
por: Sun, Dongfeng, et al.
Publicado: (2021)

Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage
por: Gai, Zhibo, et al.
Publicado: (2017)

Drug-induced liver injury: recent advances in diagnosis and risk assessment
por: Kullak-Ublick, Gerd A, et al.
Publicado: (2017)

Effects of Farnesiferol B on Ischemia-Reperfusion-Induced Renal Damage, Inflammation, and NF-κB Signaling
por: Zhang, Lu, et al.
Publicado: (2019)

The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes
por: Schaffner, Carlos A, et al.
Publicado: (2015)

FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome
por: Karsai, Gergely, et al.
Publicado: (2020)

Sterol and Sphingoid Glycoconjugates from Microalgae
por: Stonik, Valentin A., et al.
Publicado: (2018)

A new framework for advancing in drug‐induced liver injury research. The Prospective European DILI Registry
por: Björnsson, Einar S., et al.
Publicado: (2022)

Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity
por: Russmann, Stefan, et al.
Publicado: (2009)

Drug-induced liver injury: the dawn of biomarkers?
por: Weiler, Stefan, et al.
Publicado: (2015)

Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review
por: Niu, Hao, et al.
Publicado: (2022)

Astragaloside IV alleviates 1-deoxysphinganine-induced mitochondrial dysfunction during the progression of chronic kidney disease through p62-Nrf2 antioxidant pathway
por: Gui, Ting, et al.
Publicado: (2023)

New Immunosuppressive Sphingoid Base and Ceramide Analogues in Wild Cordyceps
por: Mi, Jia-Ning, et al.
Publicado: (2016)

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa
por: Pewzner-Jung, Yael, et al.
Publicado: (2014)

Leishmania (Viannia) braziliensis Inositol Phosphorylceramide: Distinctive Sphingoid Base Composition
por: De Castro Levatti, Erica V., et al.
Publicado: (2017)

Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx
por: Saied, Essa M., et al.
Publicado: (2021)

The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course
por: Mwinyi, Jessica, et al.
Publicado: (2012)

Liver Safety Assessment in Special Populations (Hepatitis B, C, and Oncology Trials)
por: Kullak-Ublick, Gerd A., et al.
Publicado: (2014)

The idiosyncratic nature of confidence
por: Navajas, Joaquin, et al.
Publicado: (2017)

Ionic Liquids Chemical Stress Triggers Sphingoid Base Accumulation in Aspergillus nidulans
por: Hartmann, Diego O., et al.
Publicado: (2019)

Methodology to Assess Clinical Liver Safety Data
por: Merz, Michael, et al.
Publicado: (2014)

Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case–control study
por: Grove, Jane I., et al.
Publicado: (2023)

Dose-Dependent Effects on Sphingoid Bases and Cytokines in Chickens Fed Diets Prepared with Fusarium Verticillioides Culture Material Containing Fumonisins
por: Grenier, Bertrand, et al.
Publicado: (2015)

Thematic Review Series: Sphingolipids. Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols
por: Pruett, Sarah T., et al.
Publicado: (2008)

Leucettamols, Bifunctionalized Marine Sphingoids, Act as Modulators of TRPA1 and TRPM8 Channels
por: Chianese, Giuseppina, et al.
Publicado: (2012)

Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans
por: Hannich, J. Thomas, et al.
Publicado: (2017)

Idiosyncratic learning performance in flies
por: Smith, Matthew A.-Y., et al.
Publicado: (2022)

A Mobile App to Stabilize Daily Functional Activity of Breast Cancer Patients in Collaboration With the Physician: A Randomized Controlled Clinical Trial
por: Egbring, Marco, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_29pcbfsn8iejmng4iq4do6pan4