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Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions?

Dermoscopic features of actinic keratosis (AK) have been widely studied, but there is still little evidence for their diagnostic accuracy. Our study investigates whether established dermoscopic criteria are reliable predictors in differentiating non-pigmented actinic keratosis (NPAK) from pigmented...

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Autores principales: Sgouros, Dimitrios, Theofili, Melpomeni, Zafeiropoulou, Theodora, Lallas, Aimilios, Apalla, Zoe, Zaras, Alexios, Liopyris, Konstantinos, Pappa, Georgia, Polychronaki, Eleni, Kousta, Fiori, Panagiotopoulos, Antonios, Stratigos, Alexander, Rigopoulos, Dimitrios, Katoulis, Alexander C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917853/
https://www.ncbi.nlm.nih.gov/pubmed/36769711
http://dx.doi.org/10.3390/jcm12031063
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author Sgouros, Dimitrios
Theofili, Melpomeni
Zafeiropoulou, Theodora
Lallas, Aimilios
Apalla, Zoe
Zaras, Alexios
Liopyris, Konstantinos
Pappa, Georgia
Polychronaki, Eleni
Kousta, Fiori
Panagiotopoulos, Antonios
Stratigos, Alexander
Rigopoulos, Dimitrios
Katoulis, Alexander C.
author_facet Sgouros, Dimitrios
Theofili, Melpomeni
Zafeiropoulou, Theodora
Lallas, Aimilios
Apalla, Zoe
Zaras, Alexios
Liopyris, Konstantinos
Pappa, Georgia
Polychronaki, Eleni
Kousta, Fiori
Panagiotopoulos, Antonios
Stratigos, Alexander
Rigopoulos, Dimitrios
Katoulis, Alexander C.
author_sort Sgouros, Dimitrios
collection PubMed
description Dermoscopic features of actinic keratosis (AK) have been widely studied, but there is still little evidence for their diagnostic accuracy. Our study investigates whether established dermoscopic criteria are reliable predictors in differentiating non-pigmented actinic keratosis (NPAK) from pigmented actinic keratosis (PAK). For this purpose, dermoscopic images of 83 clinically diagnosed AK (45 NPAK, 38PAK) were examined, and the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) were assessed. Features with statistical significance were the red pseudo-network (p = 0.02) for NPAK and the pigmented pseudo-network (p < 0.001) with a pigment intensity value even less than 10% for PAK (p = 0.001). Pigmented pseudo-network (Se: 89%, Sp: 77%, PPV: 77%, NPV: 89%) with a pigment intensity value of more than 10% (Se: 90%, Sp: 86%, PPV: 79%, NPV: 93%) had excellent diagnostic accuracy for PAK. Scale and widened follicular openings with yellowish dots surrounded by white circles were equally represented in both variants of AK. Linear wavy vessels and shiny streaks were more prominently observed in NPAK, as were rosettes in PAK, but these results failed to meet statistical significance. The red starburst pattern was near statistical significance for PAK. Therefore, pigmentation is the strongest dermoscopic predictor for the differentiation between NPAK and PAK.
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spelling pubmed-99178532023-02-11 Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions? Sgouros, Dimitrios Theofili, Melpomeni Zafeiropoulou, Theodora Lallas, Aimilios Apalla, Zoe Zaras, Alexios Liopyris, Konstantinos Pappa, Georgia Polychronaki, Eleni Kousta, Fiori Panagiotopoulos, Antonios Stratigos, Alexander Rigopoulos, Dimitrios Katoulis, Alexander C. J Clin Med Article Dermoscopic features of actinic keratosis (AK) have been widely studied, but there is still little evidence for their diagnostic accuracy. Our study investigates whether established dermoscopic criteria are reliable predictors in differentiating non-pigmented actinic keratosis (NPAK) from pigmented actinic keratosis (PAK). For this purpose, dermoscopic images of 83 clinically diagnosed AK (45 NPAK, 38PAK) were examined, and the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) were assessed. Features with statistical significance were the red pseudo-network (p = 0.02) for NPAK and the pigmented pseudo-network (p < 0.001) with a pigment intensity value even less than 10% for PAK (p = 0.001). Pigmented pseudo-network (Se: 89%, Sp: 77%, PPV: 77%, NPV: 89%) with a pigment intensity value of more than 10% (Se: 90%, Sp: 86%, PPV: 79%, NPV: 93%) had excellent diagnostic accuracy for PAK. Scale and widened follicular openings with yellowish dots surrounded by white circles were equally represented in both variants of AK. Linear wavy vessels and shiny streaks were more prominently observed in NPAK, as were rosettes in PAK, but these results failed to meet statistical significance. The red starburst pattern was near statistical significance for PAK. Therefore, pigmentation is the strongest dermoscopic predictor for the differentiation between NPAK and PAK. MDPI 2023-01-30 /pmc/articles/PMC9917853/ /pubmed/36769711 http://dx.doi.org/10.3390/jcm12031063 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sgouros, Dimitrios
Theofili, Melpomeni
Zafeiropoulou, Theodora
Lallas, Aimilios
Apalla, Zoe
Zaras, Alexios
Liopyris, Konstantinos
Pappa, Georgia
Polychronaki, Eleni
Kousta, Fiori
Panagiotopoulos, Antonios
Stratigos, Alexander
Rigopoulos, Dimitrios
Katoulis, Alexander C.
Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions?
title Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions?
title_full Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions?
title_fullStr Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions?
title_full_unstemmed Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions?
title_short Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions?
title_sort dermoscopy of actinic keratosis: is there a true differentiation between non-pigmented and pigmented lesions?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917853/
https://www.ncbi.nlm.nih.gov/pubmed/36769711
http://dx.doi.org/10.3390/jcm12031063
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