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Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions?
Dermoscopic features of actinic keratosis (AK) have been widely studied, but there is still little evidence for their diagnostic accuracy. Our study investigates whether established dermoscopic criteria are reliable predictors in differentiating non-pigmented actinic keratosis (NPAK) from pigmented...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917853/ https://www.ncbi.nlm.nih.gov/pubmed/36769711 http://dx.doi.org/10.3390/jcm12031063 |
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author | Sgouros, Dimitrios Theofili, Melpomeni Zafeiropoulou, Theodora Lallas, Aimilios Apalla, Zoe Zaras, Alexios Liopyris, Konstantinos Pappa, Georgia Polychronaki, Eleni Kousta, Fiori Panagiotopoulos, Antonios Stratigos, Alexander Rigopoulos, Dimitrios Katoulis, Alexander C. |
author_facet | Sgouros, Dimitrios Theofili, Melpomeni Zafeiropoulou, Theodora Lallas, Aimilios Apalla, Zoe Zaras, Alexios Liopyris, Konstantinos Pappa, Georgia Polychronaki, Eleni Kousta, Fiori Panagiotopoulos, Antonios Stratigos, Alexander Rigopoulos, Dimitrios Katoulis, Alexander C. |
author_sort | Sgouros, Dimitrios |
collection | PubMed |
description | Dermoscopic features of actinic keratosis (AK) have been widely studied, but there is still little evidence for their diagnostic accuracy. Our study investigates whether established dermoscopic criteria are reliable predictors in differentiating non-pigmented actinic keratosis (NPAK) from pigmented actinic keratosis (PAK). For this purpose, dermoscopic images of 83 clinically diagnosed AK (45 NPAK, 38PAK) were examined, and the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) were assessed. Features with statistical significance were the red pseudo-network (p = 0.02) for NPAK and the pigmented pseudo-network (p < 0.001) with a pigment intensity value even less than 10% for PAK (p = 0.001). Pigmented pseudo-network (Se: 89%, Sp: 77%, PPV: 77%, NPV: 89%) with a pigment intensity value of more than 10% (Se: 90%, Sp: 86%, PPV: 79%, NPV: 93%) had excellent diagnostic accuracy for PAK. Scale and widened follicular openings with yellowish dots surrounded by white circles were equally represented in both variants of AK. Linear wavy vessels and shiny streaks were more prominently observed in NPAK, as were rosettes in PAK, but these results failed to meet statistical significance. The red starburst pattern was near statistical significance for PAK. Therefore, pigmentation is the strongest dermoscopic predictor for the differentiation between NPAK and PAK. |
format | Online Article Text |
id | pubmed-9917853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99178532023-02-11 Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions? Sgouros, Dimitrios Theofili, Melpomeni Zafeiropoulou, Theodora Lallas, Aimilios Apalla, Zoe Zaras, Alexios Liopyris, Konstantinos Pappa, Georgia Polychronaki, Eleni Kousta, Fiori Panagiotopoulos, Antonios Stratigos, Alexander Rigopoulos, Dimitrios Katoulis, Alexander C. J Clin Med Article Dermoscopic features of actinic keratosis (AK) have been widely studied, but there is still little evidence for their diagnostic accuracy. Our study investigates whether established dermoscopic criteria are reliable predictors in differentiating non-pigmented actinic keratosis (NPAK) from pigmented actinic keratosis (PAK). For this purpose, dermoscopic images of 83 clinically diagnosed AK (45 NPAK, 38PAK) were examined, and the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) were assessed. Features with statistical significance were the red pseudo-network (p = 0.02) for NPAK and the pigmented pseudo-network (p < 0.001) with a pigment intensity value even less than 10% for PAK (p = 0.001). Pigmented pseudo-network (Se: 89%, Sp: 77%, PPV: 77%, NPV: 89%) with a pigment intensity value of more than 10% (Se: 90%, Sp: 86%, PPV: 79%, NPV: 93%) had excellent diagnostic accuracy for PAK. Scale and widened follicular openings with yellowish dots surrounded by white circles were equally represented in both variants of AK. Linear wavy vessels and shiny streaks were more prominently observed in NPAK, as were rosettes in PAK, but these results failed to meet statistical significance. The red starburst pattern was near statistical significance for PAK. Therefore, pigmentation is the strongest dermoscopic predictor for the differentiation between NPAK and PAK. MDPI 2023-01-30 /pmc/articles/PMC9917853/ /pubmed/36769711 http://dx.doi.org/10.3390/jcm12031063 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sgouros, Dimitrios Theofili, Melpomeni Zafeiropoulou, Theodora Lallas, Aimilios Apalla, Zoe Zaras, Alexios Liopyris, Konstantinos Pappa, Georgia Polychronaki, Eleni Kousta, Fiori Panagiotopoulos, Antonios Stratigos, Alexander Rigopoulos, Dimitrios Katoulis, Alexander C. Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions? |
title | Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions? |
title_full | Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions? |
title_fullStr | Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions? |
title_full_unstemmed | Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions? |
title_short | Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions? |
title_sort | dermoscopy of actinic keratosis: is there a true differentiation between non-pigmented and pigmented lesions? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917853/ https://www.ncbi.nlm.nih.gov/pubmed/36769711 http://dx.doi.org/10.3390/jcm12031063 |
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