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The Characteristics of Dialysis Membranes: Benefits of the AN69 Membrane in Hemodialysis Patients
Patients undergoing hemodialysis (HD) experience serious cardiovascular complications, through malnutrition, inflammation, and atherosclerosis. Amputation for peripheral arterial disease (PAD) is more prevalent in patients undergoing HD than in the general population. In addition, revascularization...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917867/ https://www.ncbi.nlm.nih.gov/pubmed/36769771 http://dx.doi.org/10.3390/jcm12031123 |
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author | Kobayashi, Shuzo Ohtake, Takayasu |
author_facet | Kobayashi, Shuzo Ohtake, Takayasu |
author_sort | Kobayashi, Shuzo |
collection | PubMed |
description | Patients undergoing hemodialysis (HD) experience serious cardiovascular complications, through malnutrition, inflammation, and atherosclerosis. Amputation for peripheral arterial disease (PAD) is more prevalent in patients undergoing HD than in the general population. In addition, revascularization procedures in dialysis patients are often associated with subsequent amputation and high mortality rates. To improve the prognosis of dialysis patients, malnutrition and inflammation must be properly treated, which necessitates a better understanding of the characteristics of dialysis membranes. Herein, the characteristics of several dialysis membranes were studied, with a special reference to the AN69 membrane, noting several similarities to low-density lipoprotein (LDL)-apheresis, which is also applicable for the treatment of PAD. Both systems (LDL-apheresis and AN69) have anti-inflammatory and anti-thrombogenic effects because they use a negatively charged surface for extracorporeal adsorptive filtration from the blood/plasma, and contact phase activation. The concomitant use of both these therapeutic systems may have additive therapeutic benefits in HD patients. Here, we reviewed the characteristics of dialysis membranes and benefits of the AN69 membrane in dialysis patients. |
format | Online Article Text |
id | pubmed-9917867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99178672023-02-11 The Characteristics of Dialysis Membranes: Benefits of the AN69 Membrane in Hemodialysis Patients Kobayashi, Shuzo Ohtake, Takayasu J Clin Med Review Patients undergoing hemodialysis (HD) experience serious cardiovascular complications, through malnutrition, inflammation, and atherosclerosis. Amputation for peripheral arterial disease (PAD) is more prevalent in patients undergoing HD than in the general population. In addition, revascularization procedures in dialysis patients are often associated with subsequent amputation and high mortality rates. To improve the prognosis of dialysis patients, malnutrition and inflammation must be properly treated, which necessitates a better understanding of the characteristics of dialysis membranes. Herein, the characteristics of several dialysis membranes were studied, with a special reference to the AN69 membrane, noting several similarities to low-density lipoprotein (LDL)-apheresis, which is also applicable for the treatment of PAD. Both systems (LDL-apheresis and AN69) have anti-inflammatory and anti-thrombogenic effects because they use a negatively charged surface for extracorporeal adsorptive filtration from the blood/plasma, and contact phase activation. The concomitant use of both these therapeutic systems may have additive therapeutic benefits in HD patients. Here, we reviewed the characteristics of dialysis membranes and benefits of the AN69 membrane in dialysis patients. MDPI 2023-01-31 /pmc/articles/PMC9917867/ /pubmed/36769771 http://dx.doi.org/10.3390/jcm12031123 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kobayashi, Shuzo Ohtake, Takayasu The Characteristics of Dialysis Membranes: Benefits of the AN69 Membrane in Hemodialysis Patients |
title | The Characteristics of Dialysis Membranes: Benefits of the AN69 Membrane in Hemodialysis Patients |
title_full | The Characteristics of Dialysis Membranes: Benefits of the AN69 Membrane in Hemodialysis Patients |
title_fullStr | The Characteristics of Dialysis Membranes: Benefits of the AN69 Membrane in Hemodialysis Patients |
title_full_unstemmed | The Characteristics of Dialysis Membranes: Benefits of the AN69 Membrane in Hemodialysis Patients |
title_short | The Characteristics of Dialysis Membranes: Benefits of the AN69 Membrane in Hemodialysis Patients |
title_sort | characteristics of dialysis membranes: benefits of the an69 membrane in hemodialysis patients |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917867/ https://www.ncbi.nlm.nih.gov/pubmed/36769771 http://dx.doi.org/10.3390/jcm12031123 |
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