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Correlations between Maternal and Fetal Outcomes in Pregnant Women with Kidney Failure

Background: Kidney function impairment in pregnancy is challenging, with incidence and prognosis only partially known. Studies concerning maternal and fetal outcomes in pregnancies occurring in patients with renal injury and the therapeutic strategies for improving the prognosis of these patients ar...

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Autores principales: Meca, Daniela-Catalina, Varlas, Valentin Nicolae, Mehedințu, Claudia, Cîrstoiu, Monica Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917987/
https://www.ncbi.nlm.nih.gov/pubmed/36769480
http://dx.doi.org/10.3390/jcm12030832
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author Meca, Daniela-Catalina
Varlas, Valentin Nicolae
Mehedințu, Claudia
Cîrstoiu, Monica Mihaela
author_facet Meca, Daniela-Catalina
Varlas, Valentin Nicolae
Mehedințu, Claudia
Cîrstoiu, Monica Mihaela
author_sort Meca, Daniela-Catalina
collection PubMed
description Background: Kidney function impairment in pregnancy is challenging, with incidence and prognosis only partially known. Studies concerning maternal and fetal outcomes in pregnancies occurring in patients with renal injury and the therapeutic strategies for improving the prognosis of these patients are scarce due to the limited number of cases reported. Objectives: We aimed to establish correlations between the main maternal and fetal outcomes in patients with severe CKD or AKI in pregnancy to improve the prognosis, referring to a control group of patients with mild kidney impairment. Methods: For this purpose, we conducted a retrospective study, at University Emergency Hospital in Bucharest, Romania, from January 2019 until December 2021, selecting 38 patients with AKI and 12 patients diagnosed with advanced CKD, compared to 42 patients displaying borderline values of serum creatinine (0.8–1 mg/dL), reflecting the presence of milder kidney impairment. Results: The probability of having a child that is premature and small for gestational age, with a lower Apgar score and more frequent neonatal intensive care unit admissions, delivered by cesarean section, is higher in patients with highly reduced kidney function. Conclusion: Severe kidney function impairment is associated with a grim fetal prognosis and obstetrical complications.
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spelling pubmed-99179872023-02-11 Correlations between Maternal and Fetal Outcomes in Pregnant Women with Kidney Failure Meca, Daniela-Catalina Varlas, Valentin Nicolae Mehedințu, Claudia Cîrstoiu, Monica Mihaela J Clin Med Article Background: Kidney function impairment in pregnancy is challenging, with incidence and prognosis only partially known. Studies concerning maternal and fetal outcomes in pregnancies occurring in patients with renal injury and the therapeutic strategies for improving the prognosis of these patients are scarce due to the limited number of cases reported. Objectives: We aimed to establish correlations between the main maternal and fetal outcomes in patients with severe CKD or AKI in pregnancy to improve the prognosis, referring to a control group of patients with mild kidney impairment. Methods: For this purpose, we conducted a retrospective study, at University Emergency Hospital in Bucharest, Romania, from January 2019 until December 2021, selecting 38 patients with AKI and 12 patients diagnosed with advanced CKD, compared to 42 patients displaying borderline values of serum creatinine (0.8–1 mg/dL), reflecting the presence of milder kidney impairment. Results: The probability of having a child that is premature and small for gestational age, with a lower Apgar score and more frequent neonatal intensive care unit admissions, delivered by cesarean section, is higher in patients with highly reduced kidney function. Conclusion: Severe kidney function impairment is associated with a grim fetal prognosis and obstetrical complications. MDPI 2023-01-20 /pmc/articles/PMC9917987/ /pubmed/36769480 http://dx.doi.org/10.3390/jcm12030832 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meca, Daniela-Catalina
Varlas, Valentin Nicolae
Mehedințu, Claudia
Cîrstoiu, Monica Mihaela
Correlations between Maternal and Fetal Outcomes in Pregnant Women with Kidney Failure
title Correlations between Maternal and Fetal Outcomes in Pregnant Women with Kidney Failure
title_full Correlations between Maternal and Fetal Outcomes in Pregnant Women with Kidney Failure
title_fullStr Correlations between Maternal and Fetal Outcomes in Pregnant Women with Kidney Failure
title_full_unstemmed Correlations between Maternal and Fetal Outcomes in Pregnant Women with Kidney Failure
title_short Correlations between Maternal and Fetal Outcomes in Pregnant Women with Kidney Failure
title_sort correlations between maternal and fetal outcomes in pregnant women with kidney failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917987/
https://www.ncbi.nlm.nih.gov/pubmed/36769480
http://dx.doi.org/10.3390/jcm12030832
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