Cargando…

Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes

Background: The aims of this study were to evaluate the clinical outcomes and their predictive factors in locally advanced hypopharyngeal cancer (HC) patients included in a docetaxel-cisplatin-fluorouracil induction chemotherapy (ICT)-based larynx preservation (LP) program. Methods: Between 2005 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Mattei, Pierre, Gal, Jocelyn, Chamorey, Emmanuel, Dassonville, Olivier, Poissonnet, Gilles, Aloi, Déborah, Barret, Médéric, Safta, Inga, Saada, Esma, Sudaka, Anne, Culié, Dorian, Bozec, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918009/
https://www.ncbi.nlm.nih.gov/pubmed/36769779
http://dx.doi.org/10.3390/jcm12031131
_version_ 1784886506822828032
author Mattei, Pierre
Gal, Jocelyn
Chamorey, Emmanuel
Dassonville, Olivier
Poissonnet, Gilles
Aloi, Déborah
Barret, Médéric
Safta, Inga
Saada, Esma
Sudaka, Anne
Culié, Dorian
Bozec, Alexandre
author_facet Mattei, Pierre
Gal, Jocelyn
Chamorey, Emmanuel
Dassonville, Olivier
Poissonnet, Gilles
Aloi, Déborah
Barret, Médéric
Safta, Inga
Saada, Esma
Sudaka, Anne
Culié, Dorian
Bozec, Alexandre
author_sort Mattei, Pierre
collection PubMed
description Background: The aims of this study were to evaluate the clinical outcomes and their predictive factors in locally advanced hypopharyngeal cancer (HC) patients included in a docetaxel-cisplatin-fluorouracil induction chemotherapy (ICT)-based larynx preservation (LP) program. Methods: Between 2005 and 2021, 82 patients with a locally advanced resectable HC who received ICT in an LP program were included in this retrospective study. The predictors of oncologic and swallowing outcomes were determined in univariate and multivariate analyses. Results: The three- and five-year overall survival (OS) rates were 67 and 54%, respectively. The T4 tumor stage was the only predictive factor of poor response to ICT (p = 0.03). In multivariate analysis, a T stage = 4 (p = 0.02), an ICT cycle number < 3 (p = 0.003) and the absence of a response to ICT (p = 0.03) were significantly associated with worse OS. A low body mass index before therapy (p = 0.003) and enteral nutrition during therapy (p = 0.005) were significantly associated with severity of dysphagia 6 months after treatment. Conclusions: The T stage, number of ICT cycles performed and response to ICT are the main predictors of oncologic outcomes. Patients with T4 HC are poor candidates for LP and should be referred to immediate radical surgery.
format Online
Article
Text
id pubmed-9918009
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99180092023-02-11 Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes Mattei, Pierre Gal, Jocelyn Chamorey, Emmanuel Dassonville, Olivier Poissonnet, Gilles Aloi, Déborah Barret, Médéric Safta, Inga Saada, Esma Sudaka, Anne Culié, Dorian Bozec, Alexandre J Clin Med Article Background: The aims of this study were to evaluate the clinical outcomes and their predictive factors in locally advanced hypopharyngeal cancer (HC) patients included in a docetaxel-cisplatin-fluorouracil induction chemotherapy (ICT)-based larynx preservation (LP) program. Methods: Between 2005 and 2021, 82 patients with a locally advanced resectable HC who received ICT in an LP program were included in this retrospective study. The predictors of oncologic and swallowing outcomes were determined in univariate and multivariate analyses. Results: The three- and five-year overall survival (OS) rates were 67 and 54%, respectively. The T4 tumor stage was the only predictive factor of poor response to ICT (p = 0.03). In multivariate analysis, a T stage = 4 (p = 0.02), an ICT cycle number < 3 (p = 0.003) and the absence of a response to ICT (p = 0.03) were significantly associated with worse OS. A low body mass index before therapy (p = 0.003) and enteral nutrition during therapy (p = 0.005) were significantly associated with severity of dysphagia 6 months after treatment. Conclusions: The T stage, number of ICT cycles performed and response to ICT are the main predictors of oncologic outcomes. Patients with T4 HC are poor candidates for LP and should be referred to immediate radical surgery. MDPI 2023-02-01 /pmc/articles/PMC9918009/ /pubmed/36769779 http://dx.doi.org/10.3390/jcm12031131 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mattei, Pierre
Gal, Jocelyn
Chamorey, Emmanuel
Dassonville, Olivier
Poissonnet, Gilles
Aloi, Déborah
Barret, Médéric
Safta, Inga
Saada, Esma
Sudaka, Anne
Culié, Dorian
Bozec, Alexandre
Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes
title Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes
title_full Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes
title_fullStr Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes
title_full_unstemmed Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes
title_short Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes
title_sort docetaxel-cisplatin-fluorouracil induction chemotherapy for larynx preservation in patients with locally advanced hypopharyngeal cancer: predictive factors of oncologic and functional outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918009/
https://www.ncbi.nlm.nih.gov/pubmed/36769779
http://dx.doi.org/10.3390/jcm12031131
work_keys_str_mv AT matteipierre docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT galjocelyn docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT chamoreyemmanuel docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT dassonvilleolivier docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT poissonnetgilles docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT aloideborah docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT barretmederic docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT saftainga docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT saadaesma docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT sudakaanne docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT culiedorian docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes
AT bozecalexandre docetaxelcisplatinfluorouracilinductionchemotherapyforlarynxpreservationinpatientswithlocallyadvancedhypopharyngealcancerpredictivefactorsofoncologicandfunctionaloutcomes