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A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging

Although the imbalance of circulating levels of Thyroid Hormones (THs) affects female fertility in vertebrates, its involvement in the promotion of Premature Ovarian Aging (POA) is debated. Therefore, altered synthesis of THs in both thyroid and ovary can be a trait of POA. We investigated the relat...

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Autores principales: Colella, Marco, Cuomo, Danila, Nittoli, Valeria, Amoresano, Angela, Porciello, Alfonsina, Reale, Carla, Roberto, Luca, Russo, Filomena, Russo, Nicola Antonino, De Felice, Mario, Mallardo, Massimo, Ambrosino, Concetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918015/
https://www.ncbi.nlm.nih.gov/pubmed/36769379
http://dx.doi.org/10.3390/ijms24033054
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author Colella, Marco
Cuomo, Danila
Nittoli, Valeria
Amoresano, Angela
Porciello, Alfonsina
Reale, Carla
Roberto, Luca
Russo, Filomena
Russo, Nicola Antonino
De Felice, Mario
Mallardo, Massimo
Ambrosino, Concetta
author_facet Colella, Marco
Cuomo, Danila
Nittoli, Valeria
Amoresano, Angela
Porciello, Alfonsina
Reale, Carla
Roberto, Luca
Russo, Filomena
Russo, Nicola Antonino
De Felice, Mario
Mallardo, Massimo
Ambrosino, Concetta
author_sort Colella, Marco
collection PubMed
description Although the imbalance of circulating levels of Thyroid Hormones (THs) affects female fertility in vertebrates, its involvement in the promotion of Premature Ovarian Aging (POA) is debated. Therefore, altered synthesis of THs in both thyroid and ovary can be a trait of POA. We investigated the relationship between abnormal TH signaling, dysthyroidism, and POA in evolutionary distant vertebrates: from zebrafish to humans. Ovarian T3 signaling/metabolism was evaluated by measuring T3 levels, T3 responsive transcript, and protein levels along with transcripts governing T3 availability (deiodinases) and signaling (TH receptors) in distinct models of POA depending on genetic background and environmental exposures (e.g., diets, pesticides). Expression levels of well-known (Amh, Gdf9, and Inhibins) and novel (miR143/145 and Gas5) biomarkers of POA were assessed. Ovarian dysthyroidism was slightly influenced by genetics since very few differences were found between C57BL/6J and FVB/NJ females. However, diets exacerbated it in a strain-dependent manner. Similar findings were observed in zebrafish and mouse models of POA induced by developmental and long-life exposure to low-dose chlorpyrifos (CPF). Lastly, the T3 decrease in follicular fluids from women affected by diminished ovarian reserve, as well as of the transcripts modulating T3 signaling/availability in the cumulus cells, confirmed ovarian dysthyroidism as a common and evolutionary conserved trait of POA.
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spelling pubmed-99180152023-02-11 A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging Colella, Marco Cuomo, Danila Nittoli, Valeria Amoresano, Angela Porciello, Alfonsina Reale, Carla Roberto, Luca Russo, Filomena Russo, Nicola Antonino De Felice, Mario Mallardo, Massimo Ambrosino, Concetta Int J Mol Sci Article Although the imbalance of circulating levels of Thyroid Hormones (THs) affects female fertility in vertebrates, its involvement in the promotion of Premature Ovarian Aging (POA) is debated. Therefore, altered synthesis of THs in both thyroid and ovary can be a trait of POA. We investigated the relationship between abnormal TH signaling, dysthyroidism, and POA in evolutionary distant vertebrates: from zebrafish to humans. Ovarian T3 signaling/metabolism was evaluated by measuring T3 levels, T3 responsive transcript, and protein levels along with transcripts governing T3 availability (deiodinases) and signaling (TH receptors) in distinct models of POA depending on genetic background and environmental exposures (e.g., diets, pesticides). Expression levels of well-known (Amh, Gdf9, and Inhibins) and novel (miR143/145 and Gas5) biomarkers of POA were assessed. Ovarian dysthyroidism was slightly influenced by genetics since very few differences were found between C57BL/6J and FVB/NJ females. However, diets exacerbated it in a strain-dependent manner. Similar findings were observed in zebrafish and mouse models of POA induced by developmental and long-life exposure to low-dose chlorpyrifos (CPF). Lastly, the T3 decrease in follicular fluids from women affected by diminished ovarian reserve, as well as of the transcripts modulating T3 signaling/availability in the cumulus cells, confirmed ovarian dysthyroidism as a common and evolutionary conserved trait of POA. MDPI 2023-02-03 /pmc/articles/PMC9918015/ /pubmed/36769379 http://dx.doi.org/10.3390/ijms24033054 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Colella, Marco
Cuomo, Danila
Nittoli, Valeria
Amoresano, Angela
Porciello, Alfonsina
Reale, Carla
Roberto, Luca
Russo, Filomena
Russo, Nicola Antonino
De Felice, Mario
Mallardo, Massimo
Ambrosino, Concetta
A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging
title A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging
title_full A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging
title_fullStr A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging
title_full_unstemmed A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging
title_short A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging
title_sort cross-species analysis reveals dysthyroidism of the ovaries as a common trait of premature ovarian aging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918015/
https://www.ncbi.nlm.nih.gov/pubmed/36769379
http://dx.doi.org/10.3390/ijms24033054
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