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3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation
Background: The lack of thermally and mechanically performant biomaterials represents the major limit for 3D-printed surgical guides, aimed at facilitating complex surgery and ablations. Methods: Cryosurgery is a treatment for cardiac arrhythmias. It consists of obtaining cryolesions, by freezing th...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918061/ https://www.ncbi.nlm.nih.gov/pubmed/36769681 http://dx.doi.org/10.3390/jcm12031036 |
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author | Candelari, Mara Cappello, Ida Anna Pannone, Luigi Monaco, Cinzia Bori, Edoardo Talevi, Giacomo Ramak, Robbert La Meir, Mark Gharaviri, Ali Chierchia, Gian Battista de Asmundis, Carlo Innocenti, Bernardo |
author_facet | Candelari, Mara Cappello, Ida Anna Pannone, Luigi Monaco, Cinzia Bori, Edoardo Talevi, Giacomo Ramak, Robbert La Meir, Mark Gharaviri, Ali Chierchia, Gian Battista de Asmundis, Carlo Innocenti, Bernardo |
author_sort | Candelari, Mara |
collection | PubMed |
description | Background: The lack of thermally and mechanically performant biomaterials represents the major limit for 3D-printed surgical guides, aimed at facilitating complex surgery and ablations. Methods: Cryosurgery is a treatment for cardiac arrhythmias. It consists of obtaining cryolesions, by freezing the target tissue, resulting in selective and irreversible damage. MED625FLX and TPU95A are two biocompatible materials for surgical guides; however, there are no data on their response to cryoenergy delivery. The study purpose is to evaluate the biomaterials’ thermal properties, examining the temperature changes on the porcine muscle samples (PMS) when the biomaterials are in place during the cryoablation. Two biomaterials were selected, MED625FLX and TPU95A, with two thicknesses (1.0 and 2.5 mm). To analyze the biomaterials’ behavior, the PMS temperatures were measured during cryoablation, firstly without biomaterials (control) and after with the biomaterials in place. To verify the biomaterials’ suitability, the temperatures under the biomaterial samples should not exceed a limit of −30.0 °C. Furthermore, the biomaterials’ geometry after cryoablation was evaluated using the grid paper test. Results: TPU95A (1.0 and 2.5 mm) successfully passed all tests, making this material suitable for cryoablation treatment. MED625FLX of 1.0 mm did not retain its shape, losing its function according to the grid paper test. Further, MED625FLX of 2.5 mm is also suitable for use with a cryoenergy source. Conclusions: TPU95A (1.0 and 2.5 mm) and MED625FLX of 2.5 mm could be used in the design of surgical guides for cryoablation treatment, because of their mechanical, geometrical, and thermal properties. The positive results from the thermal tests on these materials and their thickness prompt further clinical investigation. |
format | Online Article Text |
id | pubmed-9918061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99180612023-02-11 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation Candelari, Mara Cappello, Ida Anna Pannone, Luigi Monaco, Cinzia Bori, Edoardo Talevi, Giacomo Ramak, Robbert La Meir, Mark Gharaviri, Ali Chierchia, Gian Battista de Asmundis, Carlo Innocenti, Bernardo J Clin Med Article Background: The lack of thermally and mechanically performant biomaterials represents the major limit for 3D-printed surgical guides, aimed at facilitating complex surgery and ablations. Methods: Cryosurgery is a treatment for cardiac arrhythmias. It consists of obtaining cryolesions, by freezing the target tissue, resulting in selective and irreversible damage. MED625FLX and TPU95A are two biocompatible materials for surgical guides; however, there are no data on their response to cryoenergy delivery. The study purpose is to evaluate the biomaterials’ thermal properties, examining the temperature changes on the porcine muscle samples (PMS) when the biomaterials are in place during the cryoablation. Two biomaterials were selected, MED625FLX and TPU95A, with two thicknesses (1.0 and 2.5 mm). To analyze the biomaterials’ behavior, the PMS temperatures were measured during cryoablation, firstly without biomaterials (control) and after with the biomaterials in place. To verify the biomaterials’ suitability, the temperatures under the biomaterial samples should not exceed a limit of −30.0 °C. Furthermore, the biomaterials’ geometry after cryoablation was evaluated using the grid paper test. Results: TPU95A (1.0 and 2.5 mm) successfully passed all tests, making this material suitable for cryoablation treatment. MED625FLX of 1.0 mm did not retain its shape, losing its function according to the grid paper test. Further, MED625FLX of 2.5 mm is also suitable for use with a cryoenergy source. Conclusions: TPU95A (1.0 and 2.5 mm) and MED625FLX of 2.5 mm could be used in the design of surgical guides for cryoablation treatment, because of their mechanical, geometrical, and thermal properties. The positive results from the thermal tests on these materials and their thickness prompt further clinical investigation. MDPI 2023-01-29 /pmc/articles/PMC9918061/ /pubmed/36769681 http://dx.doi.org/10.3390/jcm12031036 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Candelari, Mara Cappello, Ida Anna Pannone, Luigi Monaco, Cinzia Bori, Edoardo Talevi, Giacomo Ramak, Robbert La Meir, Mark Gharaviri, Ali Chierchia, Gian Battista de Asmundis, Carlo Innocenti, Bernardo 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation |
title | 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation |
title_full | 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation |
title_fullStr | 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation |
title_full_unstemmed | 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation |
title_short | 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation |
title_sort | 3d-printed biomaterial testing in response to cryoablation: implications for surgical ventricular tachycardia ablation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918061/ https://www.ncbi.nlm.nih.gov/pubmed/36769681 http://dx.doi.org/10.3390/jcm12031036 |
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