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3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation

Background: The lack of thermally and mechanically performant biomaterials represents the major limit for 3D-printed surgical guides, aimed at facilitating complex surgery and ablations. Methods: Cryosurgery is a treatment for cardiac arrhythmias. It consists of obtaining cryolesions, by freezing th...

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Autores principales: Candelari, Mara, Cappello, Ida Anna, Pannone, Luigi, Monaco, Cinzia, Bori, Edoardo, Talevi, Giacomo, Ramak, Robbert, La Meir, Mark, Gharaviri, Ali, Chierchia, Gian Battista, de Asmundis, Carlo, Innocenti, Bernardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918061/
https://www.ncbi.nlm.nih.gov/pubmed/36769681
http://dx.doi.org/10.3390/jcm12031036
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author Candelari, Mara
Cappello, Ida Anna
Pannone, Luigi
Monaco, Cinzia
Bori, Edoardo
Talevi, Giacomo
Ramak, Robbert
La Meir, Mark
Gharaviri, Ali
Chierchia, Gian Battista
de Asmundis, Carlo
Innocenti, Bernardo
author_facet Candelari, Mara
Cappello, Ida Anna
Pannone, Luigi
Monaco, Cinzia
Bori, Edoardo
Talevi, Giacomo
Ramak, Robbert
La Meir, Mark
Gharaviri, Ali
Chierchia, Gian Battista
de Asmundis, Carlo
Innocenti, Bernardo
author_sort Candelari, Mara
collection PubMed
description Background: The lack of thermally and mechanically performant biomaterials represents the major limit for 3D-printed surgical guides, aimed at facilitating complex surgery and ablations. Methods: Cryosurgery is a treatment for cardiac arrhythmias. It consists of obtaining cryolesions, by freezing the target tissue, resulting in selective and irreversible damage. MED625FLX and TPU95A are two biocompatible materials for surgical guides; however, there are no data on their response to cryoenergy delivery. The study purpose is to evaluate the biomaterials’ thermal properties, examining the temperature changes on the porcine muscle samples (PMS) when the biomaterials are in place during the cryoablation. Two biomaterials were selected, MED625FLX and TPU95A, with two thicknesses (1.0 and 2.5 mm). To analyze the biomaterials’ behavior, the PMS temperatures were measured during cryoablation, firstly without biomaterials (control) and after with the biomaterials in place. To verify the biomaterials’ suitability, the temperatures under the biomaterial samples should not exceed a limit of −30.0 °C. Furthermore, the biomaterials’ geometry after cryoablation was evaluated using the grid paper test. Results: TPU95A (1.0 and 2.5 mm) successfully passed all tests, making this material suitable for cryoablation treatment. MED625FLX of 1.0 mm did not retain its shape, losing its function according to the grid paper test. Further, MED625FLX of 2.5 mm is also suitable for use with a cryoenergy source. Conclusions: TPU95A (1.0 and 2.5 mm) and MED625FLX of 2.5 mm could be used in the design of surgical guides for cryoablation treatment, because of their mechanical, geometrical, and thermal properties. The positive results from the thermal tests on these materials and their thickness prompt further clinical investigation.
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spelling pubmed-99180612023-02-11 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation Candelari, Mara Cappello, Ida Anna Pannone, Luigi Monaco, Cinzia Bori, Edoardo Talevi, Giacomo Ramak, Robbert La Meir, Mark Gharaviri, Ali Chierchia, Gian Battista de Asmundis, Carlo Innocenti, Bernardo J Clin Med Article Background: The lack of thermally and mechanically performant biomaterials represents the major limit for 3D-printed surgical guides, aimed at facilitating complex surgery and ablations. Methods: Cryosurgery is a treatment for cardiac arrhythmias. It consists of obtaining cryolesions, by freezing the target tissue, resulting in selective and irreversible damage. MED625FLX and TPU95A are two biocompatible materials for surgical guides; however, there are no data on their response to cryoenergy delivery. The study purpose is to evaluate the biomaterials’ thermal properties, examining the temperature changes on the porcine muscle samples (PMS) when the biomaterials are in place during the cryoablation. Two biomaterials were selected, MED625FLX and TPU95A, with two thicknesses (1.0 and 2.5 mm). To analyze the biomaterials’ behavior, the PMS temperatures were measured during cryoablation, firstly without biomaterials (control) and after with the biomaterials in place. To verify the biomaterials’ suitability, the temperatures under the biomaterial samples should not exceed a limit of −30.0 °C. Furthermore, the biomaterials’ geometry after cryoablation was evaluated using the grid paper test. Results: TPU95A (1.0 and 2.5 mm) successfully passed all tests, making this material suitable for cryoablation treatment. MED625FLX of 1.0 mm did not retain its shape, losing its function according to the grid paper test. Further, MED625FLX of 2.5 mm is also suitable for use with a cryoenergy source. Conclusions: TPU95A (1.0 and 2.5 mm) and MED625FLX of 2.5 mm could be used in the design of surgical guides for cryoablation treatment, because of their mechanical, geometrical, and thermal properties. The positive results from the thermal tests on these materials and their thickness prompt further clinical investigation. MDPI 2023-01-29 /pmc/articles/PMC9918061/ /pubmed/36769681 http://dx.doi.org/10.3390/jcm12031036 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Candelari, Mara
Cappello, Ida Anna
Pannone, Luigi
Monaco, Cinzia
Bori, Edoardo
Talevi, Giacomo
Ramak, Robbert
La Meir, Mark
Gharaviri, Ali
Chierchia, Gian Battista
de Asmundis, Carlo
Innocenti, Bernardo
3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation
title 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation
title_full 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation
title_fullStr 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation
title_full_unstemmed 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation
title_short 3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation
title_sort 3d-printed biomaterial testing in response to cryoablation: implications for surgical ventricular tachycardia ablation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918061/
https://www.ncbi.nlm.nih.gov/pubmed/36769681
http://dx.doi.org/10.3390/jcm12031036
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