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A Deep Learning Model for Evaluating Meibomian Glands Morphology from Meibography

To develop a deep learning model for automatically segmenting tarsus and meibomian gland areas on meibography, we included 1087 meibography images from dry eye patients. The contour of the tarsus and each meibomian gland was labeled manually by human experts. The dataset was divided into training, v...

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Autores principales: Wang, Yuexin, Shi, Faqiang, Wei, Shanshan, Li, Xuemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918190/
https://www.ncbi.nlm.nih.gov/pubmed/36769701
http://dx.doi.org/10.3390/jcm12031053
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author Wang, Yuexin
Shi, Faqiang
Wei, Shanshan
Li, Xuemin
author_facet Wang, Yuexin
Shi, Faqiang
Wei, Shanshan
Li, Xuemin
author_sort Wang, Yuexin
collection PubMed
description To develop a deep learning model for automatically segmenting tarsus and meibomian gland areas on meibography, we included 1087 meibography images from dry eye patients. The contour of the tarsus and each meibomian gland was labeled manually by human experts. The dataset was divided into training, validation, and test sets. We built a convolutional neural network-based U-net and trained the model to segment the tarsus and meibomian gland area. Accuracy, sensitivity, specificity, and receiver operating characteristic curve (ROC) were calculated to evaluate the model. The area under the curve (AUC) values for models segmenting the tarsus and meibomian gland area were 0.985 and 0.938, respectively. The deep learning model achieved a sensitivity and specificity of 0.975 and 0.99, respectively, with an accuracy of 0.985 for segmenting the tarsus area. For meibomian gland area segmentation, the model obtained a high specificity of 0.96, with high accuracy of 0.937 and a moderate sensitivity of 0.751. The present research trained a deep learning model to automatically segment tarsus and the meibomian gland area from infrared meibography, and the model demonstrated outstanding accuracy in segmentation. With further improvement, the model could potentially be applied to assess the meibomian gland that facilitates dry eye evaluation in various clinical and research scenarios.
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spelling pubmed-99181902023-02-11 A Deep Learning Model for Evaluating Meibomian Glands Morphology from Meibography Wang, Yuexin Shi, Faqiang Wei, Shanshan Li, Xuemin J Clin Med Article To develop a deep learning model for automatically segmenting tarsus and meibomian gland areas on meibography, we included 1087 meibography images from dry eye patients. The contour of the tarsus and each meibomian gland was labeled manually by human experts. The dataset was divided into training, validation, and test sets. We built a convolutional neural network-based U-net and trained the model to segment the tarsus and meibomian gland area. Accuracy, sensitivity, specificity, and receiver operating characteristic curve (ROC) were calculated to evaluate the model. The area under the curve (AUC) values for models segmenting the tarsus and meibomian gland area were 0.985 and 0.938, respectively. The deep learning model achieved a sensitivity and specificity of 0.975 and 0.99, respectively, with an accuracy of 0.985 for segmenting the tarsus area. For meibomian gland area segmentation, the model obtained a high specificity of 0.96, with high accuracy of 0.937 and a moderate sensitivity of 0.751. The present research trained a deep learning model to automatically segment tarsus and the meibomian gland area from infrared meibography, and the model demonstrated outstanding accuracy in segmentation. With further improvement, the model could potentially be applied to assess the meibomian gland that facilitates dry eye evaluation in various clinical and research scenarios. MDPI 2023-01-29 /pmc/articles/PMC9918190/ /pubmed/36769701 http://dx.doi.org/10.3390/jcm12031053 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Yuexin
Shi, Faqiang
Wei, Shanshan
Li, Xuemin
A Deep Learning Model for Evaluating Meibomian Glands Morphology from Meibography
title A Deep Learning Model for Evaluating Meibomian Glands Morphology from Meibography
title_full A Deep Learning Model for Evaluating Meibomian Glands Morphology from Meibography
title_fullStr A Deep Learning Model for Evaluating Meibomian Glands Morphology from Meibography
title_full_unstemmed A Deep Learning Model for Evaluating Meibomian Glands Morphology from Meibography
title_short A Deep Learning Model for Evaluating Meibomian Glands Morphology from Meibography
title_sort deep learning model for evaluating meibomian glands morphology from meibography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918190/
https://www.ncbi.nlm.nih.gov/pubmed/36769701
http://dx.doi.org/10.3390/jcm12031053
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