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Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women

Although estrogen possesses both pro- and anti-oxidant properties, its overall role in oxidative stress among women remains unclear, particularly since the influence of exogenously administered estrogen during previous studies differed by dose, administration route, and estrogen type. The aim of thi...

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Autores principales: Ishikawa, Ayaka, Matsushita, Hiroshi, Shimizu, Saki, Morita, Noriko, Hanai, Rina, Sugiyama, Saeko, Watanabe, Kazushi, Wakatsuki, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918227/
https://www.ncbi.nlm.nih.gov/pubmed/36769477
http://dx.doi.org/10.3390/jcm12030829
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author Ishikawa, Ayaka
Matsushita, Hiroshi
Shimizu, Saki
Morita, Noriko
Hanai, Rina
Sugiyama, Saeko
Watanabe, Kazushi
Wakatsuki, Akihiko
author_facet Ishikawa, Ayaka
Matsushita, Hiroshi
Shimizu, Saki
Morita, Noriko
Hanai, Rina
Sugiyama, Saeko
Watanabe, Kazushi
Wakatsuki, Akihiko
author_sort Ishikawa, Ayaka
collection PubMed
description Although estrogen possesses both pro- and anti-oxidant properties, its overall role in oxidative stress among women remains unclear, particularly since the influence of exogenously administered estrogen during previous studies differed by dose, administration route, and estrogen type. The aim of this study was to elucidate the effects of endogenous estrogen on oxidative stress in women. Thus, we performed a non-interventional observational study of healthy postmenopausal (n = 71) and premenopausal (n = 72) female volunteers. Serum levels of derivatives of reactive oxygen metabolites (d-ROMs, which are collectively a marker of oxidative stress), as well as the biological antioxidant potential (BAP, an indicator of antioxidant capacity), were compared between (1) pre- versus post-menopausal women, and (2) premenopausal women in early follicular versus mid-luteal phases of their menstrual cycles. We found that serum d-ROMs and BAP values in postmenopausal women were significantly higher than those in premenopausal women. Moreover, the d-ROM levels were significantly correlated with serum copper concentrations. However, neither d-ROMs nor BAP values were significantly affected by the menstrual cycle phase, although changes in d-ROMs between the follicular and luteal phases were significantly correlated with copper concentration shifts. These data indicate that postmenopausal hypoestrogenism is associated with elevated oxidative stress, although regular fluctuations of estrogen levels during the menstrual cycle do not influence oxidative stress.
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spelling pubmed-99182272023-02-11 Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women Ishikawa, Ayaka Matsushita, Hiroshi Shimizu, Saki Morita, Noriko Hanai, Rina Sugiyama, Saeko Watanabe, Kazushi Wakatsuki, Akihiko J Clin Med Article Although estrogen possesses both pro- and anti-oxidant properties, its overall role in oxidative stress among women remains unclear, particularly since the influence of exogenously administered estrogen during previous studies differed by dose, administration route, and estrogen type. The aim of this study was to elucidate the effects of endogenous estrogen on oxidative stress in women. Thus, we performed a non-interventional observational study of healthy postmenopausal (n = 71) and premenopausal (n = 72) female volunteers. Serum levels of derivatives of reactive oxygen metabolites (d-ROMs, which are collectively a marker of oxidative stress), as well as the biological antioxidant potential (BAP, an indicator of antioxidant capacity), were compared between (1) pre- versus post-menopausal women, and (2) premenopausal women in early follicular versus mid-luteal phases of their menstrual cycles. We found that serum d-ROMs and BAP values in postmenopausal women were significantly higher than those in premenopausal women. Moreover, the d-ROM levels were significantly correlated with serum copper concentrations. However, neither d-ROMs nor BAP values were significantly affected by the menstrual cycle phase, although changes in d-ROMs between the follicular and luteal phases were significantly correlated with copper concentration shifts. These data indicate that postmenopausal hypoestrogenism is associated with elevated oxidative stress, although regular fluctuations of estrogen levels during the menstrual cycle do not influence oxidative stress. MDPI 2023-01-20 /pmc/articles/PMC9918227/ /pubmed/36769477 http://dx.doi.org/10.3390/jcm12030829 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ishikawa, Ayaka
Matsushita, Hiroshi
Shimizu, Saki
Morita, Noriko
Hanai, Rina
Sugiyama, Saeko
Watanabe, Kazushi
Wakatsuki, Akihiko
Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women
title Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women
title_full Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women
title_fullStr Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women
title_full_unstemmed Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women
title_short Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women
title_sort impact of menopause and the menstrual cycle on oxidative stress in japanese women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918227/
https://www.ncbi.nlm.nih.gov/pubmed/36769477
http://dx.doi.org/10.3390/jcm12030829
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