Cargando…
Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women
Although estrogen possesses both pro- and anti-oxidant properties, its overall role in oxidative stress among women remains unclear, particularly since the influence of exogenously administered estrogen during previous studies differed by dose, administration route, and estrogen type. The aim of thi...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918227/ https://www.ncbi.nlm.nih.gov/pubmed/36769477 http://dx.doi.org/10.3390/jcm12030829 |
_version_ | 1784886562013577216 |
---|---|
author | Ishikawa, Ayaka Matsushita, Hiroshi Shimizu, Saki Morita, Noriko Hanai, Rina Sugiyama, Saeko Watanabe, Kazushi Wakatsuki, Akihiko |
author_facet | Ishikawa, Ayaka Matsushita, Hiroshi Shimizu, Saki Morita, Noriko Hanai, Rina Sugiyama, Saeko Watanabe, Kazushi Wakatsuki, Akihiko |
author_sort | Ishikawa, Ayaka |
collection | PubMed |
description | Although estrogen possesses both pro- and anti-oxidant properties, its overall role in oxidative stress among women remains unclear, particularly since the influence of exogenously administered estrogen during previous studies differed by dose, administration route, and estrogen type. The aim of this study was to elucidate the effects of endogenous estrogen on oxidative stress in women. Thus, we performed a non-interventional observational study of healthy postmenopausal (n = 71) and premenopausal (n = 72) female volunteers. Serum levels of derivatives of reactive oxygen metabolites (d-ROMs, which are collectively a marker of oxidative stress), as well as the biological antioxidant potential (BAP, an indicator of antioxidant capacity), were compared between (1) pre- versus post-menopausal women, and (2) premenopausal women in early follicular versus mid-luteal phases of their menstrual cycles. We found that serum d-ROMs and BAP values in postmenopausal women were significantly higher than those in premenopausal women. Moreover, the d-ROM levels were significantly correlated with serum copper concentrations. However, neither d-ROMs nor BAP values were significantly affected by the menstrual cycle phase, although changes in d-ROMs between the follicular and luteal phases were significantly correlated with copper concentration shifts. These data indicate that postmenopausal hypoestrogenism is associated with elevated oxidative stress, although regular fluctuations of estrogen levels during the menstrual cycle do not influence oxidative stress. |
format | Online Article Text |
id | pubmed-9918227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99182272023-02-11 Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women Ishikawa, Ayaka Matsushita, Hiroshi Shimizu, Saki Morita, Noriko Hanai, Rina Sugiyama, Saeko Watanabe, Kazushi Wakatsuki, Akihiko J Clin Med Article Although estrogen possesses both pro- and anti-oxidant properties, its overall role in oxidative stress among women remains unclear, particularly since the influence of exogenously administered estrogen during previous studies differed by dose, administration route, and estrogen type. The aim of this study was to elucidate the effects of endogenous estrogen on oxidative stress in women. Thus, we performed a non-interventional observational study of healthy postmenopausal (n = 71) and premenopausal (n = 72) female volunteers. Serum levels of derivatives of reactive oxygen metabolites (d-ROMs, which are collectively a marker of oxidative stress), as well as the biological antioxidant potential (BAP, an indicator of antioxidant capacity), were compared between (1) pre- versus post-menopausal women, and (2) premenopausal women in early follicular versus mid-luteal phases of their menstrual cycles. We found that serum d-ROMs and BAP values in postmenopausal women were significantly higher than those in premenopausal women. Moreover, the d-ROM levels were significantly correlated with serum copper concentrations. However, neither d-ROMs nor BAP values were significantly affected by the menstrual cycle phase, although changes in d-ROMs between the follicular and luteal phases were significantly correlated with copper concentration shifts. These data indicate that postmenopausal hypoestrogenism is associated with elevated oxidative stress, although regular fluctuations of estrogen levels during the menstrual cycle do not influence oxidative stress. MDPI 2023-01-20 /pmc/articles/PMC9918227/ /pubmed/36769477 http://dx.doi.org/10.3390/jcm12030829 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ishikawa, Ayaka Matsushita, Hiroshi Shimizu, Saki Morita, Noriko Hanai, Rina Sugiyama, Saeko Watanabe, Kazushi Wakatsuki, Akihiko Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women |
title | Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women |
title_full | Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women |
title_fullStr | Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women |
title_full_unstemmed | Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women |
title_short | Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women |
title_sort | impact of menopause and the menstrual cycle on oxidative stress in japanese women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918227/ https://www.ncbi.nlm.nih.gov/pubmed/36769477 http://dx.doi.org/10.3390/jcm12030829 |
work_keys_str_mv | AT ishikawaayaka impactofmenopauseandthemenstrualcycleonoxidativestressinjapanesewomen AT matsushitahiroshi impactofmenopauseandthemenstrualcycleonoxidativestressinjapanesewomen AT shimizusaki impactofmenopauseandthemenstrualcycleonoxidativestressinjapanesewomen AT moritanoriko impactofmenopauseandthemenstrualcycleonoxidativestressinjapanesewomen AT hanairina impactofmenopauseandthemenstrualcycleonoxidativestressinjapanesewomen AT sugiyamasaeko impactofmenopauseandthemenstrualcycleonoxidativestressinjapanesewomen AT watanabekazushi impactofmenopauseandthemenstrualcycleonoxidativestressinjapanesewomen AT wakatsukiakihiko impactofmenopauseandthemenstrualcycleonoxidativestressinjapanesewomen |