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Longitudinal Strain Analysis and Correlation with TIMI Frame Count in Patients with Ischemia with No Obstructive Coronary Artery (INOCA) and Microvascular Angina (MVA)

Background: The aim of the study is to evaluate the subclinical alterations of cardiac mechanics detected using speckle-tracking echocardiography and compare these data with the coronary angiography indices used during coronary angiography in a population of patients diagnosed with ischemia with no...

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Autores principales: Sucato, Vincenzo, Novo, Giuseppina, Madaudo, Cristina, Di Fazio, Luca, Vadalà, Giuseppe, Caronna, Nicola, D’Agostino, Alessandro, Evola, Salvatore, Tuttolomondo, Antonino, Galassi, Alfredo Ruggero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918252/
https://www.ncbi.nlm.nih.gov/pubmed/36769468
http://dx.doi.org/10.3390/jcm12030819
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author Sucato, Vincenzo
Novo, Giuseppina
Madaudo, Cristina
Di Fazio, Luca
Vadalà, Giuseppe
Caronna, Nicola
D’Agostino, Alessandro
Evola, Salvatore
Tuttolomondo, Antonino
Galassi, Alfredo Ruggero
author_facet Sucato, Vincenzo
Novo, Giuseppina
Madaudo, Cristina
Di Fazio, Luca
Vadalà, Giuseppe
Caronna, Nicola
D’Agostino, Alessandro
Evola, Salvatore
Tuttolomondo, Antonino
Galassi, Alfredo Ruggero
author_sort Sucato, Vincenzo
collection PubMed
description Background: The aim of the study is to evaluate the subclinical alterations of cardiac mechanics detected using speckle-tracking echocardiography and compare these data with the coronary angiography indices used during coronary angiography in a population of patients diagnosed with ischemia with no obstructive coronary artery (INOCA) and microvascular angina (MVA). Methods: The study included 85 patients admitted to our center between November 2019 and January 2022 who were diagnosed with INOCA compared with a control group of 70 healthy patients. A collection of anamnestic data and a complete cardiovascular physical examination, and echocardiogram at rest with longitudinal strain were performed for all patients. Furthermore, the TIMI frame count (TFC) for the three coronary vessels was calculated according to Gibson’s indications. All parameters were compared with a control population with similar characteristics. Results: Patients with INOCA compared to the control population showed statistically significant changes in the parameters assessed on the longitudinal strain analysis. In particular, patients with INOCA showed statistically significant changes in GLS (−16.71) compared to the control population (−19.64) (p = 0.003). In patients with INOCA, the total TIMI frame count (tTFC) correlated with the GLS value with a correlation coefficient of 0.418 (p = 0.021). Conclusions: In patients with angina, documented myocardial ischemia, the absence of angiographically significant stenosis (INOCA) and LVEF > 50%, the prevalence of microvascular dysfunction documented by TFC was extremely represented. A statistically significant reduction in GLS was observed in these patients. TFC and longitudinal strain, therefore, appear to be two reliable, sensitive and easily accessible methods for the study of alterations in coronary microcirculation and the characterization of patients with INOCA and microvascular angina.
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spelling pubmed-99182522023-02-11 Longitudinal Strain Analysis and Correlation with TIMI Frame Count in Patients with Ischemia with No Obstructive Coronary Artery (INOCA) and Microvascular Angina (MVA) Sucato, Vincenzo Novo, Giuseppina Madaudo, Cristina Di Fazio, Luca Vadalà, Giuseppe Caronna, Nicola D’Agostino, Alessandro Evola, Salvatore Tuttolomondo, Antonino Galassi, Alfredo Ruggero J Clin Med Article Background: The aim of the study is to evaluate the subclinical alterations of cardiac mechanics detected using speckle-tracking echocardiography and compare these data with the coronary angiography indices used during coronary angiography in a population of patients diagnosed with ischemia with no obstructive coronary artery (INOCA) and microvascular angina (MVA). Methods: The study included 85 patients admitted to our center between November 2019 and January 2022 who were diagnosed with INOCA compared with a control group of 70 healthy patients. A collection of anamnestic data and a complete cardiovascular physical examination, and echocardiogram at rest with longitudinal strain were performed for all patients. Furthermore, the TIMI frame count (TFC) for the three coronary vessels was calculated according to Gibson’s indications. All parameters were compared with a control population with similar characteristics. Results: Patients with INOCA compared to the control population showed statistically significant changes in the parameters assessed on the longitudinal strain analysis. In particular, patients with INOCA showed statistically significant changes in GLS (−16.71) compared to the control population (−19.64) (p = 0.003). In patients with INOCA, the total TIMI frame count (tTFC) correlated with the GLS value with a correlation coefficient of 0.418 (p = 0.021). Conclusions: In patients with angina, documented myocardial ischemia, the absence of angiographically significant stenosis (INOCA) and LVEF > 50%, the prevalence of microvascular dysfunction documented by TFC was extremely represented. A statistically significant reduction in GLS was observed in these patients. TFC and longitudinal strain, therefore, appear to be two reliable, sensitive and easily accessible methods for the study of alterations in coronary microcirculation and the characterization of patients with INOCA and microvascular angina. MDPI 2023-01-19 /pmc/articles/PMC9918252/ /pubmed/36769468 http://dx.doi.org/10.3390/jcm12030819 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sucato, Vincenzo
Novo, Giuseppina
Madaudo, Cristina
Di Fazio, Luca
Vadalà, Giuseppe
Caronna, Nicola
D’Agostino, Alessandro
Evola, Salvatore
Tuttolomondo, Antonino
Galassi, Alfredo Ruggero
Longitudinal Strain Analysis and Correlation with TIMI Frame Count in Patients with Ischemia with No Obstructive Coronary Artery (INOCA) and Microvascular Angina (MVA)
title Longitudinal Strain Analysis and Correlation with TIMI Frame Count in Patients with Ischemia with No Obstructive Coronary Artery (INOCA) and Microvascular Angina (MVA)
title_full Longitudinal Strain Analysis and Correlation with TIMI Frame Count in Patients with Ischemia with No Obstructive Coronary Artery (INOCA) and Microvascular Angina (MVA)
title_fullStr Longitudinal Strain Analysis and Correlation with TIMI Frame Count in Patients with Ischemia with No Obstructive Coronary Artery (INOCA) and Microvascular Angina (MVA)
title_full_unstemmed Longitudinal Strain Analysis and Correlation with TIMI Frame Count in Patients with Ischemia with No Obstructive Coronary Artery (INOCA) and Microvascular Angina (MVA)
title_short Longitudinal Strain Analysis and Correlation with TIMI Frame Count in Patients with Ischemia with No Obstructive Coronary Artery (INOCA) and Microvascular Angina (MVA)
title_sort longitudinal strain analysis and correlation with timi frame count in patients with ischemia with no obstructive coronary artery (inoca) and microvascular angina (mva)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918252/
https://www.ncbi.nlm.nih.gov/pubmed/36769468
http://dx.doi.org/10.3390/jcm12030819
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