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Post-Stroke Status Epilepticus: Time of Occurrence May Be the Difference?

(1) Background: Stroke is one of the most frequent causes of status epilepticus (SE) in adults. Patients with stroke and SE have poorer prognosis than those with stroke alone. We described characteristics and prognosis of early- and late-onset post-stroke SE (PSSE). (2) Methods: We retrospectively a...

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Autores principales: Nilo, Annacarmen, Pauletto, Giada, Lorenzut, Simone, Merlino, Giovanni, Verriello, Lorenzo, Janes, Francesco, Bax, Francesco, Gigli, Gian Luigi, Valente, Mariarosaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918271/
https://www.ncbi.nlm.nih.gov/pubmed/36769417
http://dx.doi.org/10.3390/jcm12030769
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author Nilo, Annacarmen
Pauletto, Giada
Lorenzut, Simone
Merlino, Giovanni
Verriello, Lorenzo
Janes, Francesco
Bax, Francesco
Gigli, Gian Luigi
Valente, Mariarosaria
author_facet Nilo, Annacarmen
Pauletto, Giada
Lorenzut, Simone
Merlino, Giovanni
Verriello, Lorenzo
Janes, Francesco
Bax, Francesco
Gigli, Gian Luigi
Valente, Mariarosaria
author_sort Nilo, Annacarmen
collection PubMed
description (1) Background: Stroke is one of the most frequent causes of status epilepticus (SE) in adults. Patients with stroke and SE have poorer prognosis than those with stroke alone. We described characteristics and prognosis of early- and late-onset post-stroke SE (PSSE). (2) Methods: We retrospectively analyzed consecutive stroke patients who experienced a first SE between August 2012 and April 2021, comparing clinical characteristics, stroke, and SE features between early- versus late-onset SE in relation to patients’ outcome. (3) Results: Forty stroke patients experienced PSSE. Fourteen developed an early-onset SE (35%) and twenty-six a late-onset SE (65%). Early-onset SE patients had a slightly higher NIHSS score at admission (6.9 vs. 6.0; p = 0.05). Early-onset SE was more severe than late-onset, according to STESS (Status Epilepticus Severity Score) (3.5 vs. 2.8; p = 0.05) and EMSE (Epidemiology-based Mortality score in Status Epilepticus) score (97.0 vs. 69.5; p = 0.04); furthermore, it had a significant impact on disability at 3-month and 1-year follow-up (p = 0.03 and p = 0.02). SE recurrence and seizures relapse were observed mainly in cases of late-onset SE. (4) Conclusions: Early-onset SE seems to be associated with higher disability in short- and long-term follow-up as possible expression of severe acute brain damage.
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spelling pubmed-99182712023-02-11 Post-Stroke Status Epilepticus: Time of Occurrence May Be the Difference? Nilo, Annacarmen Pauletto, Giada Lorenzut, Simone Merlino, Giovanni Verriello, Lorenzo Janes, Francesco Bax, Francesco Gigli, Gian Luigi Valente, Mariarosaria J Clin Med Article (1) Background: Stroke is one of the most frequent causes of status epilepticus (SE) in adults. Patients with stroke and SE have poorer prognosis than those with stroke alone. We described characteristics and prognosis of early- and late-onset post-stroke SE (PSSE). (2) Methods: We retrospectively analyzed consecutive stroke patients who experienced a first SE between August 2012 and April 2021, comparing clinical characteristics, stroke, and SE features between early- versus late-onset SE in relation to patients’ outcome. (3) Results: Forty stroke patients experienced PSSE. Fourteen developed an early-onset SE (35%) and twenty-six a late-onset SE (65%). Early-onset SE patients had a slightly higher NIHSS score at admission (6.9 vs. 6.0; p = 0.05). Early-onset SE was more severe than late-onset, according to STESS (Status Epilepticus Severity Score) (3.5 vs. 2.8; p = 0.05) and EMSE (Epidemiology-based Mortality score in Status Epilepticus) score (97.0 vs. 69.5; p = 0.04); furthermore, it had a significant impact on disability at 3-month and 1-year follow-up (p = 0.03 and p = 0.02). SE recurrence and seizures relapse were observed mainly in cases of late-onset SE. (4) Conclusions: Early-onset SE seems to be associated with higher disability in short- and long-term follow-up as possible expression of severe acute brain damage. MDPI 2023-01-18 /pmc/articles/PMC9918271/ /pubmed/36769417 http://dx.doi.org/10.3390/jcm12030769 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nilo, Annacarmen
Pauletto, Giada
Lorenzut, Simone
Merlino, Giovanni
Verriello, Lorenzo
Janes, Francesco
Bax, Francesco
Gigli, Gian Luigi
Valente, Mariarosaria
Post-Stroke Status Epilepticus: Time of Occurrence May Be the Difference?
title Post-Stroke Status Epilepticus: Time of Occurrence May Be the Difference?
title_full Post-Stroke Status Epilepticus: Time of Occurrence May Be the Difference?
title_fullStr Post-Stroke Status Epilepticus: Time of Occurrence May Be the Difference?
title_full_unstemmed Post-Stroke Status Epilepticus: Time of Occurrence May Be the Difference?
title_short Post-Stroke Status Epilepticus: Time of Occurrence May Be the Difference?
title_sort post-stroke status epilepticus: time of occurrence may be the difference?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918271/
https://www.ncbi.nlm.nih.gov/pubmed/36769417
http://dx.doi.org/10.3390/jcm12030769
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