Is Endothelial Activation a Critical Event in Thrombotic Thrombocytopenic Purpura?

Thrombotic thrombocytopenic purpura (TTP) is a severe thrombotic microangiopathy. The current pathophysiologic paradigm suggests that the ADAMTS13 deficiency leads to Ultra Large-Von Willebrand Factor multimers accumulation with generation of disseminated microthrombi. Nevertheless, the role of endo...

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Detalles Bibliográficos
Autores principales: Cauchois, Raphael, Muller, Romain, Lagarde, Marie, Dignat-George, Françoise, Tellier, Edwige, Kaplanski, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918301/
https://www.ncbi.nlm.nih.gov/pubmed/36769407
http://dx.doi.org/10.3390/jcm12030758

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