A vector-encoded bispecific killer engager to harness virus-activated NK cells as anti-tumor effectors

Treatment with oncolytic measles vaccines (MV) elicits activation of immune cells, including natural killer (NK) cells. However, we found that MV-activated NK cells show only modest direct cytotoxic activity against tumor cells. To specifically direct NK cells towards tumor cells, we developed oncol...

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Detalles Bibliográficos
Autores principales: Floerchinger, Alessia, Klein, Jessica E., Finkbeiner, Maximiliane S. C., Schäfer, Theresa E., Fuchs, Gwendolin, Doerner, Johannes, Zirngibl, Hubert, Ackermann, Maximilian, Kvasnicka, Hans M., Chester, Kerry A., Jäger, Dirk, Ball, Claudia R., Ungerechts, Guy, Engeland, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918448/
https://www.ncbi.nlm.nih.gov/pubmed/36765035
http://dx.doi.org/10.1038/s41419-023-05624-3

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