Role of NAT10-mediated ac4C-modified HSP90AA1 RNA acetylation in ER stress-mediated metastasis and lenvatinib resistance in hepatocellular carcinoma

Emerging evidence showed that epigenetic regulation plays important role in the pathogenesis of HCC. N4-acetocytidine (ac4C) was an acetylation chemical modification of mRNA, and NAT10 is reported to regulate ac4C modification and enhance endoplasmic reticulum stress (ERS) in tumor metastasis. Here,...

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Detalles Bibliográficos
Autores principales: Pan, Zhipeng, Bao, Yawei, Hu, Mengyao, Zhu, Yue, Tan, Chaisheng, Fan, Lulu, Yu, Hanqing, Wang, Anqi, Cui, Jie, Sun, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918514/
https://www.ncbi.nlm.nih.gov/pubmed/36765042
http://dx.doi.org/10.1038/s41420-023-01355-8

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