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Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach

The association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduced. 110 single nucleotide polymorphisms (SNPs) associated with 25-hydroxyvitamin D concentr...

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Autores principales: Katagiri, Ryoko, Goto, Atsushi, Nakano, Shiori, Nakatochi, Masahiro, Koyanagi, Yuriko N., Iwagami, Masao, Hanyuda, Akiko, Yamaji, Taiki, Sawada, Norie, Nakamura, Yohko, Nakamura, Sho, Kuriki, Kiyonori, Suzuki, Sadao, Imoto, Issei, Momozawa, Yukihide, Oze, Isao, Ito, Hidemi, Tsugane, Shoichiro, Wakai, Kenji, Matsuo, Keitaro, Iwasaki, Motoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918529/
https://www.ncbi.nlm.nih.gov/pubmed/36765195
http://dx.doi.org/10.1038/s41598-023-29596-8
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author Katagiri, Ryoko
Goto, Atsushi
Nakano, Shiori
Nakatochi, Masahiro
Koyanagi, Yuriko N.
Iwagami, Masao
Hanyuda, Akiko
Yamaji, Taiki
Sawada, Norie
Nakamura, Yohko
Nakamura, Sho
Kuriki, Kiyonori
Suzuki, Sadao
Imoto, Issei
Momozawa, Yukihide
Oze, Isao
Ito, Hidemi
Tsugane, Shoichiro
Wakai, Kenji
Matsuo, Keitaro
Iwasaki, Motoki
author_facet Katagiri, Ryoko
Goto, Atsushi
Nakano, Shiori
Nakatochi, Masahiro
Koyanagi, Yuriko N.
Iwagami, Masao
Hanyuda, Akiko
Yamaji, Taiki
Sawada, Norie
Nakamura, Yohko
Nakamura, Sho
Kuriki, Kiyonori
Suzuki, Sadao
Imoto, Issei
Momozawa, Yukihide
Oze, Isao
Ito, Hidemi
Tsugane, Shoichiro
Wakai, Kenji
Matsuo, Keitaro
Iwasaki, Motoki
author_sort Katagiri, Ryoko
collection PubMed
description The association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduced. 110 single nucleotide polymorphisms (SNPs) associated with 25-hydroxyvitamin D concentrations were systematically selected according to the “GWAS Catalog” from all ethnic populations. For the SNP-vitamin D concentration association, 3978 individuals from two Japanese cohorts were included. Regarding SNP-total and colorectal cancer association, 4543 cancer cases and 14,224 controls and 7936 colorectal cancer cases and 38,042 controls, respectively were included from the Japanese Consortium of Genetic Epidemiology and other studies in Japan. There was no significant association between the genetically predicted plasma 25-hydroxyvitamin D concentration and total or colorectal cancer in any of the MR analyses. Odds ratios per doubling in vitamin D concentration were 0.83 (95% confidence interval [CI] 0.63–1.09) for total cancer and 1.00 (95% CI 0.80–1.24) for colorectal cancer in inverse variance weighted method, 0.83 (95% CI 0.57–1.19) for total cancer and 1.01 (95% CI 0.75–1.37) for colorectal cancer in MR-Egger method. Consistent with previous MR analyses among European ancestries, there was no significant association identified between 25-hydroxyvitamin D levels and total or colorectal cancer among Asians.
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spelling pubmed-99185292023-02-12 Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach Katagiri, Ryoko Goto, Atsushi Nakano, Shiori Nakatochi, Masahiro Koyanagi, Yuriko N. Iwagami, Masao Hanyuda, Akiko Yamaji, Taiki Sawada, Norie Nakamura, Yohko Nakamura, Sho Kuriki, Kiyonori Suzuki, Sadao Imoto, Issei Momozawa, Yukihide Oze, Isao Ito, Hidemi Tsugane, Shoichiro Wakai, Kenji Matsuo, Keitaro Iwasaki, Motoki Sci Rep Article The association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduced. 110 single nucleotide polymorphisms (SNPs) associated with 25-hydroxyvitamin D concentrations were systematically selected according to the “GWAS Catalog” from all ethnic populations. For the SNP-vitamin D concentration association, 3978 individuals from two Japanese cohorts were included. Regarding SNP-total and colorectal cancer association, 4543 cancer cases and 14,224 controls and 7936 colorectal cancer cases and 38,042 controls, respectively were included from the Japanese Consortium of Genetic Epidemiology and other studies in Japan. There was no significant association between the genetically predicted plasma 25-hydroxyvitamin D concentration and total or colorectal cancer in any of the MR analyses. Odds ratios per doubling in vitamin D concentration were 0.83 (95% confidence interval [CI] 0.63–1.09) for total cancer and 1.00 (95% CI 0.80–1.24) for colorectal cancer in inverse variance weighted method, 0.83 (95% CI 0.57–1.19) for total cancer and 1.01 (95% CI 0.75–1.37) for colorectal cancer in MR-Egger method. Consistent with previous MR analyses among European ancestries, there was no significant association identified between 25-hydroxyvitamin D levels and total or colorectal cancer among Asians. Nature Publishing Group UK 2023-02-10 /pmc/articles/PMC9918529/ /pubmed/36765195 http://dx.doi.org/10.1038/s41598-023-29596-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Katagiri, Ryoko
Goto, Atsushi
Nakano, Shiori
Nakatochi, Masahiro
Koyanagi, Yuriko N.
Iwagami, Masao
Hanyuda, Akiko
Yamaji, Taiki
Sawada, Norie
Nakamura, Yohko
Nakamura, Sho
Kuriki, Kiyonori
Suzuki, Sadao
Imoto, Issei
Momozawa, Yukihide
Oze, Isao
Ito, Hidemi
Tsugane, Shoichiro
Wakai, Kenji
Matsuo, Keitaro
Iwasaki, Motoki
Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach
title Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach
title_full Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach
title_fullStr Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach
title_full_unstemmed Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach
title_short Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach
title_sort association of 25-hydroxyvitamin d with risk of overall and colorectal cancer among japanese using a mendelian randomization approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918529/
https://www.ncbi.nlm.nih.gov/pubmed/36765195
http://dx.doi.org/10.1038/s41598-023-29596-8
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