O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N(6)-methyladenosine-dependent manner

Hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC), but its pathogenic mechanism remains to be explored. The RNA N(6)-methyladenosine (m(6)A) reader, YTH (YT521-B homology) domain 2 (YTHDF2), plays a critical role in the HCC progression. However, the function...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Yan, Yu, Yin, Jiaxin, Tang, Ni, Wang, Kai, Huang, Luyi, Hu, Jie, Feng, Zhongqi, Gao, Qingzhu, Huang, Ailong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918532/
https://www.ncbi.nlm.nih.gov/pubmed/36765030
http://dx.doi.org/10.1038/s41392-023-01316-8

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