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Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trial

BACKGROUND: WHO recommends a three-dose infant pneumococcal conjugate vaccine (PCV) schedule administered as a two-dose primary series with booster (2 + 1) or a three-dose primary series (3 + 0). Data on carriage impacts of these and further reduced PCV schedules are needed to inform PCV strategies....

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Autores principales: Smith-Vaughan, Heidi, Temple, Beth, Trang Dai, Vo Thi, Hoan, Pham Thi, Loc Thuy, Ho Nguyen, Phan, Thanh V., Bright, Kathryn, Toan, Nguyen Trong, Uyen, Doan Y., Nguyen, Cattram Duong, Beissbarth, Jemima, Ortika, Belinda Daniela, Nation, Monica Larissa, Dunne, Eileen Margaret, Hinds, Jason, Lai, Jana, Satzke, Catherine, Huu, Tran Ngoc, Mulholland, Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918756/
https://www.ncbi.nlm.nih.gov/pubmed/36785850
http://dx.doi.org/10.1016/j.lanwpc.2022.100651
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author Smith-Vaughan, Heidi
Temple, Beth
Trang Dai, Vo Thi
Hoan, Pham Thi
Loc Thuy, Ho Nguyen
Phan, Thanh V.
Bright, Kathryn
Toan, Nguyen Trong
Uyen, Doan Y.
Nguyen, Cattram Duong
Beissbarth, Jemima
Ortika, Belinda Daniela
Nation, Monica Larissa
Dunne, Eileen Margaret
Hinds, Jason
Lai, Jana
Satzke, Catherine
Huu, Tran Ngoc
Mulholland, Kim
author_facet Smith-Vaughan, Heidi
Temple, Beth
Trang Dai, Vo Thi
Hoan, Pham Thi
Loc Thuy, Ho Nguyen
Phan, Thanh V.
Bright, Kathryn
Toan, Nguyen Trong
Uyen, Doan Y.
Nguyen, Cattram Duong
Beissbarth, Jemima
Ortika, Belinda Daniela
Nation, Monica Larissa
Dunne, Eileen Margaret
Hinds, Jason
Lai, Jana
Satzke, Catherine
Huu, Tran Ngoc
Mulholland, Kim
author_sort Smith-Vaughan, Heidi
collection PubMed
description BACKGROUND: WHO recommends a three-dose infant pneumococcal conjugate vaccine (PCV) schedule administered as a two-dose primary series with booster (2 + 1) or a three-dose primary series (3 + 0). Data on carriage impacts of these and further reduced PCV schedules are needed to inform PCV strategies. Here we evaluate the efficacy against carriage of four different PCV10 schedules. METHODS: Participants within an open-label, randomised controlled trial in Ho Chi Minh City, Vietnam, were allocated to receive PCV10 in a 3 + 1 (2,3,4,9 months, n = 152), 3 + 0 (2,3,4 months, n = 149), 2 + 1 (2,4,9.5 months, n = 250) or novel two-dose (2,6 months, n = 202) schedule, or no infant doses of PCV (two control groups, n = 197 and n = 199). Nasopharyngeal swabs collected between 2 and 24 months were analysed (blinded) for pneumococcal carriage and serotypes. Trial registration: ClinicalTrials.gov NCT01953510. FINDINGS: Pneumococcal carriage prevalence was low (10.6–14.1% for vaccine-type (VT) at 12–24 months in unvaccinated controls). All four PCV10 schedules reduced VT carriage compared with controls (the 2 + 1 schedule at 12, 18, and 24 months; the 3 + 1 and two-dose schedules at 18 months; and the 3 + 0 schedule at 24 months), with maximum reductions of 40.1%–64.5%. There were no differences in VT carriage prevalence at 6 or 9 months comparing three-dose and two-dose primary series, and no differences at 12, 18, or 24 months when comparing schedules with and without a booster dose. INTERPRETATION: In Vietnamese children with a relatively low pneumococcal carriage prevalence, 3 + 1, 2 + 1, 3 + 0 and two-dose PCV10 schedules were effective in reducing VT carriage. There were no discernible differences in the effect on carriage of the WHO-recommended 2 + 1 and 3 + 0 schedules during the first two years of life. Together with the previously reported immunogenicity data, this trial suggests that a range of PCV schedules are likely to generate significant direct and indirect protection. FUNDING: 10.13039/501100000925NHMRC, 10.13039/100000865BMGF
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spelling pubmed-99187562023-02-12 Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trial Smith-Vaughan, Heidi Temple, Beth Trang Dai, Vo Thi Hoan, Pham Thi Loc Thuy, Ho Nguyen Phan, Thanh V. Bright, Kathryn Toan, Nguyen Trong Uyen, Doan Y. Nguyen, Cattram Duong Beissbarth, Jemima Ortika, Belinda Daniela Nation, Monica Larissa Dunne, Eileen Margaret Hinds, Jason Lai, Jana Satzke, Catherine Huu, Tran Ngoc Mulholland, Kim Lancet Reg Health West Pac Articles BACKGROUND: WHO recommends a three-dose infant pneumococcal conjugate vaccine (PCV) schedule administered as a two-dose primary series with booster (2 + 1) or a three-dose primary series (3 + 0). Data on carriage impacts of these and further reduced PCV schedules are needed to inform PCV strategies. Here we evaluate the efficacy against carriage of four different PCV10 schedules. METHODS: Participants within an open-label, randomised controlled trial in Ho Chi Minh City, Vietnam, were allocated to receive PCV10 in a 3 + 1 (2,3,4,9 months, n = 152), 3 + 0 (2,3,4 months, n = 149), 2 + 1 (2,4,9.5 months, n = 250) or novel two-dose (2,6 months, n = 202) schedule, or no infant doses of PCV (two control groups, n = 197 and n = 199). Nasopharyngeal swabs collected between 2 and 24 months were analysed (blinded) for pneumococcal carriage and serotypes. Trial registration: ClinicalTrials.gov NCT01953510. FINDINGS: Pneumococcal carriage prevalence was low (10.6–14.1% for vaccine-type (VT) at 12–24 months in unvaccinated controls). All four PCV10 schedules reduced VT carriage compared with controls (the 2 + 1 schedule at 12, 18, and 24 months; the 3 + 1 and two-dose schedules at 18 months; and the 3 + 0 schedule at 24 months), with maximum reductions of 40.1%–64.5%. There were no differences in VT carriage prevalence at 6 or 9 months comparing three-dose and two-dose primary series, and no differences at 12, 18, or 24 months when comparing schedules with and without a booster dose. INTERPRETATION: In Vietnamese children with a relatively low pneumococcal carriage prevalence, 3 + 1, 2 + 1, 3 + 0 and two-dose PCV10 schedules were effective in reducing VT carriage. There were no discernible differences in the effect on carriage of the WHO-recommended 2 + 1 and 3 + 0 schedules during the first two years of life. Together with the previously reported immunogenicity data, this trial suggests that a range of PCV schedules are likely to generate significant direct and indirect protection. FUNDING: 10.13039/501100000925NHMRC, 10.13039/100000865BMGF Elsevier 2022-12-03 /pmc/articles/PMC9918756/ /pubmed/36785850 http://dx.doi.org/10.1016/j.lanwpc.2022.100651 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Articles
Smith-Vaughan, Heidi
Temple, Beth
Trang Dai, Vo Thi
Hoan, Pham Thi
Loc Thuy, Ho Nguyen
Phan, Thanh V.
Bright, Kathryn
Toan, Nguyen Trong
Uyen, Doan Y.
Nguyen, Cattram Duong
Beissbarth, Jemima
Ortika, Belinda Daniela
Nation, Monica Larissa
Dunne, Eileen Margaret
Hinds, Jason
Lai, Jana
Satzke, Catherine
Huu, Tran Ngoc
Mulholland, Kim
Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trial
title Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trial
title_full Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trial
title_fullStr Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trial
title_full_unstemmed Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trial
title_short Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trial
title_sort effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in vietnamese infants: results from a randomised controlled trial
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918756/
https://www.ncbi.nlm.nih.gov/pubmed/36785850
http://dx.doi.org/10.1016/j.lanwpc.2022.100651
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