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Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study
Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegenera...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919011/ https://www.ncbi.nlm.nih.gov/pubmed/36771381 http://dx.doi.org/10.3390/nu15030674 |
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author | Mayer, Carola Nägele, Felix L. Petersen, Marvin Schell, Maximilian Aarabi, Ghazal Beikler, Thomas Borof, Katrin Frey, Benedikt M. Nikorowitsch, Julius Senftinger, Juliana Walther, Carolin Wenzel, Jan-Per Zyriax, Birgit-Christiane Cheng, Bastian Thomalla, Götz |
author_facet | Mayer, Carola Nägele, Felix L. Petersen, Marvin Schell, Maximilian Aarabi, Ghazal Beikler, Thomas Borof, Katrin Frey, Benedikt M. Nikorowitsch, Julius Senftinger, Juliana Walther, Carolin Wenzel, Jan-Per Zyriax, Birgit-Christiane Cheng, Bastian Thomalla, Götz |
author_sort | Mayer, Carola |
collection | PubMed |
description | Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegeneration, and microstructural integrity in 2316 participants in the population-based Hamburg City Health Study. Cortical thickness and white matter hyperintensity (WMH) load were measured on FLAIR and T1-weighted images. Microstructural white matter integrity was quantified as peak width of skeletonized mean diffusivity (PSMD) on diffusion-weighted MRI. Daily coffee consumption was assessed in five groups (<1 cup, 1–2 cups, 3–4 cups, 5–6 cups, >6 cups). In multiple linear regressions, we examined the association between brain MRI parameters and coffee consumption (reference group <1 cup). After adjustment for covariates, 3–4 cups of daily coffee were associated with lower PSMD (p = 0.028) and higher cortical thickness (p = 0.015) compared to <1 cup. Moreover, 1–2 cups per day was also associated with lower PSMD (p = 0.022). Associations with WMH load or other groups of coffee consumption were not significant (p > 0.05). The findings indicate that regular coffee consumption is positively associated with microstructural white matter integrity and cortical thickness. Further research is necessary to determine longitudinal effects of coffee on brain microstructure. |
format | Online Article Text |
id | pubmed-9919011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99190112023-02-12 Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study Mayer, Carola Nägele, Felix L. Petersen, Marvin Schell, Maximilian Aarabi, Ghazal Beikler, Thomas Borof, Katrin Frey, Benedikt M. Nikorowitsch, Julius Senftinger, Juliana Walther, Carolin Wenzel, Jan-Per Zyriax, Birgit-Christiane Cheng, Bastian Thomalla, Götz Nutrients Article Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegeneration, and microstructural integrity in 2316 participants in the population-based Hamburg City Health Study. Cortical thickness and white matter hyperintensity (WMH) load were measured on FLAIR and T1-weighted images. Microstructural white matter integrity was quantified as peak width of skeletonized mean diffusivity (PSMD) on diffusion-weighted MRI. Daily coffee consumption was assessed in five groups (<1 cup, 1–2 cups, 3–4 cups, 5–6 cups, >6 cups). In multiple linear regressions, we examined the association between brain MRI parameters and coffee consumption (reference group <1 cup). After adjustment for covariates, 3–4 cups of daily coffee were associated with lower PSMD (p = 0.028) and higher cortical thickness (p = 0.015) compared to <1 cup. Moreover, 1–2 cups per day was also associated with lower PSMD (p = 0.022). Associations with WMH load or other groups of coffee consumption were not significant (p > 0.05). The findings indicate that regular coffee consumption is positively associated with microstructural white matter integrity and cortical thickness. Further research is necessary to determine longitudinal effects of coffee on brain microstructure. MDPI 2023-01-28 /pmc/articles/PMC9919011/ /pubmed/36771381 http://dx.doi.org/10.3390/nu15030674 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mayer, Carola Nägele, Felix L. Petersen, Marvin Schell, Maximilian Aarabi, Ghazal Beikler, Thomas Borof, Katrin Frey, Benedikt M. Nikorowitsch, Julius Senftinger, Juliana Walther, Carolin Wenzel, Jan-Per Zyriax, Birgit-Christiane Cheng, Bastian Thomalla, Götz Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study |
title | Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study |
title_full | Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study |
title_fullStr | Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study |
title_full_unstemmed | Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study |
title_short | Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study |
title_sort | association between coffee consumption and brain mri parameters in the hamburg city health study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919011/ https://www.ncbi.nlm.nih.gov/pubmed/36771381 http://dx.doi.org/10.3390/nu15030674 |
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