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Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study

Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegenera...

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Autores principales: Mayer, Carola, Nägele, Felix L., Petersen, Marvin, Schell, Maximilian, Aarabi, Ghazal, Beikler, Thomas, Borof, Katrin, Frey, Benedikt M., Nikorowitsch, Julius, Senftinger, Juliana, Walther, Carolin, Wenzel, Jan-Per, Zyriax, Birgit-Christiane, Cheng, Bastian, Thomalla, Götz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919011/
https://www.ncbi.nlm.nih.gov/pubmed/36771381
http://dx.doi.org/10.3390/nu15030674
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author Mayer, Carola
Nägele, Felix L.
Petersen, Marvin
Schell, Maximilian
Aarabi, Ghazal
Beikler, Thomas
Borof, Katrin
Frey, Benedikt M.
Nikorowitsch, Julius
Senftinger, Juliana
Walther, Carolin
Wenzel, Jan-Per
Zyriax, Birgit-Christiane
Cheng, Bastian
Thomalla, Götz
author_facet Mayer, Carola
Nägele, Felix L.
Petersen, Marvin
Schell, Maximilian
Aarabi, Ghazal
Beikler, Thomas
Borof, Katrin
Frey, Benedikt M.
Nikorowitsch, Julius
Senftinger, Juliana
Walther, Carolin
Wenzel, Jan-Per
Zyriax, Birgit-Christiane
Cheng, Bastian
Thomalla, Götz
author_sort Mayer, Carola
collection PubMed
description Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegeneration, and microstructural integrity in 2316 participants in the population-based Hamburg City Health Study. Cortical thickness and white matter hyperintensity (WMH) load were measured on FLAIR and T1-weighted images. Microstructural white matter integrity was quantified as peak width of skeletonized mean diffusivity (PSMD) on diffusion-weighted MRI. Daily coffee consumption was assessed in five groups (<1 cup, 1–2 cups, 3–4 cups, 5–6 cups, >6 cups). In multiple linear regressions, we examined the association between brain MRI parameters and coffee consumption (reference group <1 cup). After adjustment for covariates, 3–4 cups of daily coffee were associated with lower PSMD (p = 0.028) and higher cortical thickness (p = 0.015) compared to <1 cup. Moreover, 1–2 cups per day was also associated with lower PSMD (p = 0.022). Associations with WMH load or other groups of coffee consumption were not significant (p > 0.05). The findings indicate that regular coffee consumption is positively associated with microstructural white matter integrity and cortical thickness. Further research is necessary to determine longitudinal effects of coffee on brain microstructure.
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spelling pubmed-99190112023-02-12 Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study Mayer, Carola Nägele, Felix L. Petersen, Marvin Schell, Maximilian Aarabi, Ghazal Beikler, Thomas Borof, Katrin Frey, Benedikt M. Nikorowitsch, Julius Senftinger, Juliana Walther, Carolin Wenzel, Jan-Per Zyriax, Birgit-Christiane Cheng, Bastian Thomalla, Götz Nutrients Article Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegeneration, and microstructural integrity in 2316 participants in the population-based Hamburg City Health Study. Cortical thickness and white matter hyperintensity (WMH) load were measured on FLAIR and T1-weighted images. Microstructural white matter integrity was quantified as peak width of skeletonized mean diffusivity (PSMD) on diffusion-weighted MRI. Daily coffee consumption was assessed in five groups (<1 cup, 1–2 cups, 3–4 cups, 5–6 cups, >6 cups). In multiple linear regressions, we examined the association between brain MRI parameters and coffee consumption (reference group <1 cup). After adjustment for covariates, 3–4 cups of daily coffee were associated with lower PSMD (p = 0.028) and higher cortical thickness (p = 0.015) compared to <1 cup. Moreover, 1–2 cups per day was also associated with lower PSMD (p = 0.022). Associations with WMH load or other groups of coffee consumption were not significant (p > 0.05). The findings indicate that regular coffee consumption is positively associated with microstructural white matter integrity and cortical thickness. Further research is necessary to determine longitudinal effects of coffee on brain microstructure. MDPI 2023-01-28 /pmc/articles/PMC9919011/ /pubmed/36771381 http://dx.doi.org/10.3390/nu15030674 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mayer, Carola
Nägele, Felix L.
Petersen, Marvin
Schell, Maximilian
Aarabi, Ghazal
Beikler, Thomas
Borof, Katrin
Frey, Benedikt M.
Nikorowitsch, Julius
Senftinger, Juliana
Walther, Carolin
Wenzel, Jan-Per
Zyriax, Birgit-Christiane
Cheng, Bastian
Thomalla, Götz
Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study
title Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study
title_full Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study
title_fullStr Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study
title_full_unstemmed Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study
title_short Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study
title_sort association between coffee consumption and brain mri parameters in the hamburg city health study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919011/
https://www.ncbi.nlm.nih.gov/pubmed/36771381
http://dx.doi.org/10.3390/nu15030674
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