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Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis
Vitamin D deficiency has been linked with adverse events in various liver diseases. The present study aimed to recognize the association between severe vitamin D deficiency and disease progression, hepatobiliary malignancies, liver-related mortality, and the need for liver transplantation in primary...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919120/ https://www.ncbi.nlm.nih.gov/pubmed/36771282 http://dx.doi.org/10.3390/nu15030576 |
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author | Ebadi, Maryam Rider, Elora Tsai, Catherine Wang, Sarah Lytvyak, Ellina Mason, Andrew Montano-Loza, Aldo J. |
author_facet | Ebadi, Maryam Rider, Elora Tsai, Catherine Wang, Sarah Lytvyak, Ellina Mason, Andrew Montano-Loza, Aldo J. |
author_sort | Ebadi, Maryam |
collection | PubMed |
description | Vitamin D deficiency has been linked with adverse events in various liver diseases. The present study aimed to recognize the association between severe vitamin D deficiency and disease progression, hepatobiliary malignancies, liver-related mortality, and the need for liver transplantation in primary sclerosing cholangitis (PSC). Patients with a diagnosis of PSC (n = 354), followed by the autoimmune liver disease clinic at the University of Alberta, were included. Patients with vitamin D levels < 25 nmol/L were defined as severely deficient. Univariate and multivariate analyses were conducted using the Cox proportional hazards regression models. The mean vitamin D level was 59 ± 2 nmol/L, and 63 patients (18%) had a severe vitamin D deficiency. Patients with a severe vitamin D deficiency were 2.5 times more likely to experience hepatobiliary malignancies (HR 2.55, 95% CI, 1.02–6.40, p = 0.046). A severe vitamin D deficiency at diagnosis (HR 1.82, 95% CI, 1.05–3.15, p = 0.03) and persistent deficiencies over time (HR 2.26, 95% CI, 1.17–4.37, p = 0.02) were independently associated with a higher risk of poor clinical liver outcomes. A severe vitamin D deficiency at diagnosis and persistent deficiency at longitudinal assessments were associated with liver-related mortality or the need for liver transplantation. |
format | Online Article Text |
id | pubmed-9919120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99191202023-02-12 Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis Ebadi, Maryam Rider, Elora Tsai, Catherine Wang, Sarah Lytvyak, Ellina Mason, Andrew Montano-Loza, Aldo J. Nutrients Article Vitamin D deficiency has been linked with adverse events in various liver diseases. The present study aimed to recognize the association between severe vitamin D deficiency and disease progression, hepatobiliary malignancies, liver-related mortality, and the need for liver transplantation in primary sclerosing cholangitis (PSC). Patients with a diagnosis of PSC (n = 354), followed by the autoimmune liver disease clinic at the University of Alberta, were included. Patients with vitamin D levels < 25 nmol/L were defined as severely deficient. Univariate and multivariate analyses were conducted using the Cox proportional hazards regression models. The mean vitamin D level was 59 ± 2 nmol/L, and 63 patients (18%) had a severe vitamin D deficiency. Patients with a severe vitamin D deficiency were 2.5 times more likely to experience hepatobiliary malignancies (HR 2.55, 95% CI, 1.02–6.40, p = 0.046). A severe vitamin D deficiency at diagnosis (HR 1.82, 95% CI, 1.05–3.15, p = 0.03) and persistent deficiencies over time (HR 2.26, 95% CI, 1.17–4.37, p = 0.02) were independently associated with a higher risk of poor clinical liver outcomes. A severe vitamin D deficiency at diagnosis and persistent deficiency at longitudinal assessments were associated with liver-related mortality or the need for liver transplantation. MDPI 2023-01-22 /pmc/articles/PMC9919120/ /pubmed/36771282 http://dx.doi.org/10.3390/nu15030576 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ebadi, Maryam Rider, Elora Tsai, Catherine Wang, Sarah Lytvyak, Ellina Mason, Andrew Montano-Loza, Aldo J. Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis |
title | Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis |
title_full | Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis |
title_fullStr | Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis |
title_full_unstemmed | Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis |
title_short | Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis |
title_sort | prognostic significance of severe vitamin d deficiency in patients with primary sclerosing cholangitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919120/ https://www.ncbi.nlm.nih.gov/pubmed/36771282 http://dx.doi.org/10.3390/nu15030576 |
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