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Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis

Vitamin D deficiency has been linked with adverse events in various liver diseases. The present study aimed to recognize the association between severe vitamin D deficiency and disease progression, hepatobiliary malignancies, liver-related mortality, and the need for liver transplantation in primary...

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Autores principales: Ebadi, Maryam, Rider, Elora, Tsai, Catherine, Wang, Sarah, Lytvyak, Ellina, Mason, Andrew, Montano-Loza, Aldo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919120/
https://www.ncbi.nlm.nih.gov/pubmed/36771282
http://dx.doi.org/10.3390/nu15030576
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author Ebadi, Maryam
Rider, Elora
Tsai, Catherine
Wang, Sarah
Lytvyak, Ellina
Mason, Andrew
Montano-Loza, Aldo J.
author_facet Ebadi, Maryam
Rider, Elora
Tsai, Catherine
Wang, Sarah
Lytvyak, Ellina
Mason, Andrew
Montano-Loza, Aldo J.
author_sort Ebadi, Maryam
collection PubMed
description Vitamin D deficiency has been linked with adverse events in various liver diseases. The present study aimed to recognize the association between severe vitamin D deficiency and disease progression, hepatobiliary malignancies, liver-related mortality, and the need for liver transplantation in primary sclerosing cholangitis (PSC). Patients with a diagnosis of PSC (n = 354), followed by the autoimmune liver disease clinic at the University of Alberta, were included. Patients with vitamin D levels < 25 nmol/L were defined as severely deficient. Univariate and multivariate analyses were conducted using the Cox proportional hazards regression models. The mean vitamin D level was 59 ± 2 nmol/L, and 63 patients (18%) had a severe vitamin D deficiency. Patients with a severe vitamin D deficiency were 2.5 times more likely to experience hepatobiliary malignancies (HR 2.55, 95% CI, 1.02–6.40, p = 0.046). A severe vitamin D deficiency at diagnosis (HR 1.82, 95% CI, 1.05–3.15, p = 0.03) and persistent deficiencies over time (HR 2.26, 95% CI, 1.17–4.37, p = 0.02) were independently associated with a higher risk of poor clinical liver outcomes. A severe vitamin D deficiency at diagnosis and persistent deficiency at longitudinal assessments were associated with liver-related mortality or the need for liver transplantation.
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spelling pubmed-99191202023-02-12 Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis Ebadi, Maryam Rider, Elora Tsai, Catherine Wang, Sarah Lytvyak, Ellina Mason, Andrew Montano-Loza, Aldo J. Nutrients Article Vitamin D deficiency has been linked with adverse events in various liver diseases. The present study aimed to recognize the association between severe vitamin D deficiency and disease progression, hepatobiliary malignancies, liver-related mortality, and the need for liver transplantation in primary sclerosing cholangitis (PSC). Patients with a diagnosis of PSC (n = 354), followed by the autoimmune liver disease clinic at the University of Alberta, were included. Patients with vitamin D levels < 25 nmol/L were defined as severely deficient. Univariate and multivariate analyses were conducted using the Cox proportional hazards regression models. The mean vitamin D level was 59 ± 2 nmol/L, and 63 patients (18%) had a severe vitamin D deficiency. Patients with a severe vitamin D deficiency were 2.5 times more likely to experience hepatobiliary malignancies (HR 2.55, 95% CI, 1.02–6.40, p = 0.046). A severe vitamin D deficiency at diagnosis (HR 1.82, 95% CI, 1.05–3.15, p = 0.03) and persistent deficiencies over time (HR 2.26, 95% CI, 1.17–4.37, p = 0.02) were independently associated with a higher risk of poor clinical liver outcomes. A severe vitamin D deficiency at diagnosis and persistent deficiency at longitudinal assessments were associated with liver-related mortality or the need for liver transplantation. MDPI 2023-01-22 /pmc/articles/PMC9919120/ /pubmed/36771282 http://dx.doi.org/10.3390/nu15030576 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ebadi, Maryam
Rider, Elora
Tsai, Catherine
Wang, Sarah
Lytvyak, Ellina
Mason, Andrew
Montano-Loza, Aldo J.
Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis
title Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis
title_full Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis
title_fullStr Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis
title_full_unstemmed Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis
title_short Prognostic Significance of Severe Vitamin D Deficiency in Patients with Primary Sclerosing Cholangitis
title_sort prognostic significance of severe vitamin d deficiency in patients with primary sclerosing cholangitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919120/
https://www.ncbi.nlm.nih.gov/pubmed/36771282
http://dx.doi.org/10.3390/nu15030576
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