Multivariate Regression in Conjunction with GA-BP for Optimization of Data Processing of Trace NO Gas Flow in Active Pumping Electronic Nose

Exhaled nitric oxide trace gas at the ppb level is a biomarker of human airway inflammation. To detect this, we developed a method for the collection of active pumping electronic nose bionic chamber gas. An optimization algorithm based on multivariate regression (MR) and genetic algorithm–back propagation (GA-BP) was proposed to improve the accuracy of trace-level gas detection. An electronic nose was used to detect NO gas at the ppb level by substituting breathing gas with a sample gas. The impact of the pump suction flow capacity variation on the response of the electronic nose system was determined using an ANOVA. Further, the optimization algorithm based on MR and GA-BP was studied for flow correction. The results of this study demonstrate an increase in the detection accuracy of the system by more than twofold, from 17.40%FS before correction to 6.86%FS after correction. The findings of this research lay the technical groundwork for the practical application of electronic nose systems in the daily monitoring of FeNO.