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Recent Developments in the Biological Activities, Bioproduction, and Applications of Pseudomonas spp. Phenazines

Phenazines are a large group of heterocyclic nitrogen-containing compounds with demonstrated insecticidal, antimicrobial, antiparasitic, and anticancer activities. These natural compounds are synthesized by several microorganisms originating from diverse habitats, including marine and terrestrial so...

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Detalles Bibliográficos
Autores principales: Serafim, Bruno, Bernardino, Ana R., Freitas, Filomena, Torres, Cristiana A. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919295/
https://www.ncbi.nlm.nih.gov/pubmed/36771036
http://dx.doi.org/10.3390/molecules28031368
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author Serafim, Bruno
Bernardino, Ana R.
Freitas, Filomena
Torres, Cristiana A. V.
author_facet Serafim, Bruno
Bernardino, Ana R.
Freitas, Filomena
Torres, Cristiana A. V.
author_sort Serafim, Bruno
collection PubMed
description Phenazines are a large group of heterocyclic nitrogen-containing compounds with demonstrated insecticidal, antimicrobial, antiparasitic, and anticancer activities. These natural compounds are synthesized by several microorganisms originating from diverse habitats, including marine and terrestrial sources. The most well-studied producers belong to the Pseudomonas genus, which has been extensively investigated over the years for its ability to synthesize phenazines. This review is focused on the research performed on pseudomonads’ phenazines in recent years. Their biosynthetic pathways, mechanism of regulation, production processes, bioactivities, and applications are revised in this manuscript.
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spelling pubmed-99192952023-02-12 Recent Developments in the Biological Activities, Bioproduction, and Applications of Pseudomonas spp. Phenazines Serafim, Bruno Bernardino, Ana R. Freitas, Filomena Torres, Cristiana A. V. Molecules Review Phenazines are a large group of heterocyclic nitrogen-containing compounds with demonstrated insecticidal, antimicrobial, antiparasitic, and anticancer activities. These natural compounds are synthesized by several microorganisms originating from diverse habitats, including marine and terrestrial sources. The most well-studied producers belong to the Pseudomonas genus, which has been extensively investigated over the years for its ability to synthesize phenazines. This review is focused on the research performed on pseudomonads’ phenazines in recent years. Their biosynthetic pathways, mechanism of regulation, production processes, bioactivities, and applications are revised in this manuscript. MDPI 2023-02-01 /pmc/articles/PMC9919295/ /pubmed/36771036 http://dx.doi.org/10.3390/molecules28031368 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Serafim, Bruno
Bernardino, Ana R.
Freitas, Filomena
Torres, Cristiana A. V.
Recent Developments in the Biological Activities, Bioproduction, and Applications of Pseudomonas spp. Phenazines
title Recent Developments in the Biological Activities, Bioproduction, and Applications of Pseudomonas spp. Phenazines
title_full Recent Developments in the Biological Activities, Bioproduction, and Applications of Pseudomonas spp. Phenazines
title_fullStr Recent Developments in the Biological Activities, Bioproduction, and Applications of Pseudomonas spp. Phenazines
title_full_unstemmed Recent Developments in the Biological Activities, Bioproduction, and Applications of Pseudomonas spp. Phenazines
title_short Recent Developments in the Biological Activities, Bioproduction, and Applications of Pseudomonas spp. Phenazines
title_sort recent developments in the biological activities, bioproduction, and applications of pseudomonas spp. phenazines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919295/
https://www.ncbi.nlm.nih.gov/pubmed/36771036
http://dx.doi.org/10.3390/molecules28031368
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