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A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors

An efficient one-pot synthetic method has been developed for the preparation of bicyclic carbamoyl pyridones from the known common intermediate methyl 5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate (8). The scalable protocol is facile and e...

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Detalles Bibliográficos
Autores principales:	Mahajan, Pankaj S., Smith, Steven J., Hughes, Stephen H., Zhao, Xuezhi, Burke, Terrence R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919513/ https://www.ncbi.nlm.nih.gov/pubmed/36771093 http://dx.doi.org/10.3390/molecules28031428

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