Cargando…

Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers

Novel 13α-estrone derivatives have been synthesized via direct arylation of the phenolic hydroxy function. Chan–Lam couplings of arylboronic acids with 13α-estrone as a nucleophilic partner were carried out under copper catalysis. The antiproliferative activities of the newly synthesized diaryl ethe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kovács, Édua, Ali, Hazhmat, Minorics, Renáta, Traj, Péter, Resch, Vivien, Paragi, Gábor, Bruszel, Bella, Zupkó, István, Mernyák, Erzsébet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919549/ https://www.ncbi.nlm.nih.gov/pubmed/36770863 http://dx.doi.org/10.3390/molecules28031196

Ejemplares similares

Investigation of the Antineoplastic Effects of 2-(4-Chlorophenyl)-13α-Estrone Sulfamate against the HPV16-Positive Human Invasive Cervical Carcinoma Cell Line SiHa
por: Ali, Hazhmat, et al.
Publicado: (2023)

Microwave-assisted Phospha-Michael addition reactions in the 13α-oestrone series and in vitro antiproliferative properties
por: Mernyák, Erzsébet, et al.
Publicado: (2021)

Synthesis, Biological Evaluation and Docking Studies of 13-Epimeric 10-fluoro- and 10-Chloroestra-1,4-dien-3-ones as Potential Aromatase Inhibitors
por: Jójárt, Rebeka, et al.
Publicado: (2019)

Transition metal-catalysed A-ring C–H activations and C(sp(2))–C(sp(2)) couplings in the 13α-oestrone series and in vitro evaluation of antiproliferative properties
por: Traj, Péter, et al.
Publicado: (2021)

Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives
por: Jójárt, Rebeka, et al.
Publicado: (2020)

Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative
por: Szabó, Johanna, et al.
Publicado: (2016)

Antiproliferative Properties of Newly Synthesized 19-Nortestosterone Analogs Without Substantial Androgenic Activity
por: Gyovai, András, et al.
Publicado: (2018)

Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs †
por: Senobar Tahaei, Seyyed Ashkan, et al.
Publicado: (2023)

A molecular understanding of d-homoestrone-induced G2/M cell cycle arrest in HeLa human cervical carcinoma cells
por: Minorics, Renáta, et al.
Publicado: (2015)

A Click Approach to Novel D-Ring-Substituted 16α-Triazolylestrone Derivatives and Characterization of Their Antiproliferative Properties
por: Molnár, Judit, et al.
Publicado: (2015)

Antiproliferative Activity of (−)‐Isopulegol‐based 1,3‐Oxazine, 1,3‐Thiazine and 2,4‐Diaminopyrimidine Derivatives
por: Bamou, Fatima Z., et al.
Publicado: (2022)

Screening of ligands for the Ullmann synthesis of electron-rich diaryl ethers
por: Otto, Nicola, et al.
Publicado: (2012)

Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
por: Sinreih, Maša, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Triazolyl 13α-Estrone–Nucleoside Bioconjugates
por: Bodnár, Brigitta, et al.
Publicado: (2016)

Eco-Friendly Synthesis and Antiproliferative Evaluation of Some Oxygen Substituted Diaryl Ketones
por: Arenas, Paola, et al.
Publicado: (2013)

Carbamate-directed benzylic lithiation for the diastereo- and enantioselective synthesis of diaryl ether atropisomers
por: Page, Abigail, et al.
Publicado: (2011)

Copper-catalyzed synthesis of phenol and diaryl ether derivatives via hydroxylation of diaryliodoniums
por: Ye, Lianbao, et al.
Publicado: (2019)

Diaryl ethers synthesis: nano-catalysts in carbon-oxygen cross-coupling reactions
por: Nejati, Kamellia, et al.
Publicado: (2018)

Stereoselective Synthesis and Antiproliferative Activity of Steviol-Based Diterpen Aminodiols
por: Ozsvár, Dániel, et al.
Publicado: (2019)

Synthesis and In Vitro Antiproliferative Activity of Novel Androst-5-ene Triazolyl and Tetrazolyl Derivatives
por: Kádár, Zalán, et al.
Publicado: (2011)

Investigation of Anticancer Properties of Monoterpene-Aminopyrimidine Hybrids on A2780 Ovarian Cancer Cells
por: Nagy, Viktória, et al.
Publicado: (2023)

Direct conversion of lignin to functionalized diaryl ethers via oxidative cross-coupling
por: Liu, Mingyang, et al.
Publicado: (2023)

Electrochemical oxidative decarboxylation and 1,2-aryl migration towards the synthesis of 1,2-diaryl ethers
por: Bu, Faxiang, et al.
Publicado: (2020)

Tetradentate copper complex supported on boehmite nanoparticles as an efficient and heterogeneous reusable nanocatalyst for the synthesis of diaryl ethers
por: Jabbari, Arida, et al.
Publicado: (2022)

Synthesis of novel natural product-like diaryl acetylenes as hypoxia inducible factor-1 inhibitors and antiproliferative agents
por: Wang, Shisheng, et al.
Publicado: (2019)

Photoinduced synthesis of unsymmetrical diaryl selenides from triarylbismuthines and diaryl diselenides
por: Kobiki, Yohsuke, et al.
Publicado: (2013)

Stereoselective Synthesis and Antiproliferative Activities of Tetrafunctional Diterpene Steviol Derivatives
por: Bai, Dorottya, et al.
Publicado: (2023)

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity
por: Sun, Maolin, et al.
Publicado: (2017)

Diaryl ethers with carboxymethoxyphenacyl motif as potent HIV-1 reverse transcriptase inhibitors with improved solubility
por: Frączek, Tomasz, et al.
Publicado: (2017)

Hydroxide-Mediated S(N)Ar Rearrangement for Synthesis of Novel Depside Derivatives Containing Diaryl Ether Skeleton as Antitumor Agents
por: Yu, Xiang, et al.
Publicado: (2023)

Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents
por: Cortés-Percino, Alejandra, et al.
Publicado: (2019)

Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies
por: Egharevba, Godshelp O., et al.
Publicado: (2022)

Uranyl-Photocatalyzed Hydrolysis of Diaryl Ethers at Ambient Environment for the Directional Degradation of 4-O-5 Lignin
por: Zhou, Yilin, et al.
Publicado: (2021)

Translation of microwave methodology to continuous flow for the efficient synthesis of diaryl ethers via a base-mediated S(N)Ar reaction
por: Wiles, Charlotte, et al.
Publicado: (2011)

Synthesis and In Vitro Antitumor Activity of Naringenin Oxime and Oxime Ether Derivatives
por: Latif, Ahmed Dhahir, et al.
Publicado: (2019)

In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors
por: Ibrahim, Tarek S., et al.
Publicado: (2020)

Visible-light photoredox-catalyzed C–O bond cleavage of diaryl ethers by acridinium photocatalysts at room temperature
por: Tan, Fang-Fang, et al.
Publicado: (2020)

Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening
por: de Heuvel, Erik, et al.
Publicado: (2021)

Angular Regioselective Synthesis of Varied Functionalized Hexahydro-1,2,4-triazolo[4,3-a]quinazolin-9-ones and Their Antiproliferative Action †
por: Said, Awad I., et al.
Publicado: (2023)

6,N(2)-Diaryl-1,3,5-triazine-2,4-diamines: synthesis, antiproliferative activity and 3D-QSAR modeling
por: Junaid, Ahmad, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9a6unq97jrp2fd459k34am14ct