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Lens Thickness Microfluctuations in Young and Prepresbyopic Adults During Steady-State Accommodation

PURPOSE: To determine whether lens mechanical dynamics change with age and with accommodative demands. METHODS: Lens thickness microfluctuations were measured using a high-speed custom-built spectral domain optical coherence tomography system in five young adults (20 to 25 years old) at 0 diopters (...

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Autores principales: Rohman, Leana, Ruggeri, Marco, Ho, Arthur, Parel, Jean-Marie, Manns, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919620/
https://www.ncbi.nlm.nih.gov/pubmed/36753168
http://dx.doi.org/10.1167/iovs.64.2.12
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author Rohman, Leana
Ruggeri, Marco
Ho, Arthur
Parel, Jean-Marie
Manns, Fabrice
author_facet Rohman, Leana
Ruggeri, Marco
Ho, Arthur
Parel, Jean-Marie
Manns, Fabrice
author_sort Rohman, Leana
collection PubMed
description PURPOSE: To determine whether lens mechanical dynamics change with age and with accommodative demands. METHODS: Lens thickness microfluctuations were measured using a high-speed custom-built spectral domain optical coherence tomography system in five young adults (20 to 25 years old) at 0 diopters (D), 2 D, 4 D, and maximum accommodative demand and in five prepresbyopes (38 to 45 years old) under relaxed and maximal accommodation. For each state, the measurements were repeated four times during the same session. Images of the central 2-mm zone of the lens comprising 170 A-lines/frame were acquired for 10 seconds, and axial lens thickness change was measured. Lens thickness microfluctuations (µm²/Hz) were assessed by integrating the power spectrum of lens thickness microfluctuations between 0 and 4 Hz. RESULTS: The amplitude of lens microfluctuations was higher in the accommodated states than in the relaxed state in both age groups. Lens microfluctuations were higher in young adult participants than in prepresbyopes, with a significant difference in relaxed and maximally accommodated states (P = 0.04 and P = 0.04). In the young participants, the amplitude of microfluctuations reached a plateau at maximum accommodation. CONCLUSIONS: Lens mechanical dynamics are both age and accommodation dependent. The decrease in lens thickness microfluctuations with age is consistent with an age-related increase in lens stiffness or decrease of the ciliary muscle displacement. The lens does not contribute to the high-frequency component of ocular dioptric microfluctuations.
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spelling pubmed-99196202023-02-12 Lens Thickness Microfluctuations in Young and Prepresbyopic Adults During Steady-State Accommodation Rohman, Leana Ruggeri, Marco Ho, Arthur Parel, Jean-Marie Manns, Fabrice Invest Ophthalmol Vis Sci Visual Psychophysics and Physiological Optics PURPOSE: To determine whether lens mechanical dynamics change with age and with accommodative demands. METHODS: Lens thickness microfluctuations were measured using a high-speed custom-built spectral domain optical coherence tomography system in five young adults (20 to 25 years old) at 0 diopters (D), 2 D, 4 D, and maximum accommodative demand and in five prepresbyopes (38 to 45 years old) under relaxed and maximal accommodation. For each state, the measurements were repeated four times during the same session. Images of the central 2-mm zone of the lens comprising 170 A-lines/frame were acquired for 10 seconds, and axial lens thickness change was measured. Lens thickness microfluctuations (µm²/Hz) were assessed by integrating the power spectrum of lens thickness microfluctuations between 0 and 4 Hz. RESULTS: The amplitude of lens microfluctuations was higher in the accommodated states than in the relaxed state in both age groups. Lens microfluctuations were higher in young adult participants than in prepresbyopes, with a significant difference in relaxed and maximally accommodated states (P = 0.04 and P = 0.04). In the young participants, the amplitude of microfluctuations reached a plateau at maximum accommodation. CONCLUSIONS: Lens mechanical dynamics are both age and accommodation dependent. The decrease in lens thickness microfluctuations with age is consistent with an age-related increase in lens stiffness or decrease of the ciliary muscle displacement. The lens does not contribute to the high-frequency component of ocular dioptric microfluctuations. The Association for Research in Vision and Ophthalmology 2023-02-08 /pmc/articles/PMC9919620/ /pubmed/36753168 http://dx.doi.org/10.1167/iovs.64.2.12 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Visual Psychophysics and Physiological Optics
Rohman, Leana
Ruggeri, Marco
Ho, Arthur
Parel, Jean-Marie
Manns, Fabrice
Lens Thickness Microfluctuations in Young and Prepresbyopic Adults During Steady-State Accommodation
title Lens Thickness Microfluctuations in Young and Prepresbyopic Adults During Steady-State Accommodation
title_full Lens Thickness Microfluctuations in Young and Prepresbyopic Adults During Steady-State Accommodation
title_fullStr Lens Thickness Microfluctuations in Young and Prepresbyopic Adults During Steady-State Accommodation
title_full_unstemmed Lens Thickness Microfluctuations in Young and Prepresbyopic Adults During Steady-State Accommodation
title_short Lens Thickness Microfluctuations in Young and Prepresbyopic Adults During Steady-State Accommodation
title_sort lens thickness microfluctuations in young and prepresbyopic adults during steady-state accommodation
topic Visual Psychophysics and Physiological Optics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919620/
https://www.ncbi.nlm.nih.gov/pubmed/36753168
http://dx.doi.org/10.1167/iovs.64.2.12
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