Cargando…

An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite

To protect consumers from risks related to overexposure to sulfadiazine, total residues of this antibacterial agent in animal-origin foodstuffs not exceed international regulations. To this end, a new electrochemical sensor based on a molecularly imprinted polymer nanocomposite using overoxidized po...

Descripción completa

Detalles Bibliográficos
Autores principales: Elamin, Manahil Babiker, Ali, Shazalia Mahmoud Ahmed, Essousi, Houda, Chrouda, Amani, Alhaidari, Laila M., Jaffrezic-Renault, Nicole, Barhoumi, Houcine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919664/
https://www.ncbi.nlm.nih.gov/pubmed/36772311
http://dx.doi.org/10.3390/s23031270
_version_ 1784886879107153920
author Elamin, Manahil Babiker
Ali, Shazalia Mahmoud Ahmed
Essousi, Houda
Chrouda, Amani
Alhaidari, Laila M.
Jaffrezic-Renault, Nicole
Barhoumi, Houcine
author_facet Elamin, Manahil Babiker
Ali, Shazalia Mahmoud Ahmed
Essousi, Houda
Chrouda, Amani
Alhaidari, Laila M.
Jaffrezic-Renault, Nicole
Barhoumi, Houcine
author_sort Elamin, Manahil Babiker
collection PubMed
description To protect consumers from risks related to overexposure to sulfadiazine, total residues of this antibacterial agent in animal-origin foodstuffs not exceed international regulations. To this end, a new electrochemical sensor based on a molecularly imprinted polymer nanocomposite using overoxidized polypyrrole and copper nanoparticles for the detection of sulfadiazine is elaborated. After optimization of the preparation of the electrochemical sensors, their differential pulse voltammetric signal exhibits an excellent stability and reproducibility at 1.05 V, with a large linear range between 10(−9) and 10(−5) mol L(−1) and a low detection limit of 3.1 × 10(−10) mol L(−1). The produced sulfadiazine sensor was successfully tested in real milk samples. The combination of the properties of the electrical conduction of copper nanoparticles with the properties of the preconcentration of the molecularly imprinted overoxidized polypyrrole allows for the highly sensitive detection of sulfadiazine, even in real milk samples. This strategy is new and leads to the lowest detection limit yet achieved, compared to those of the previously published sulfadiazine electrochemical sensors.
format Online
Article
Text
id pubmed-9919664
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99196642023-02-12 An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite Elamin, Manahil Babiker Ali, Shazalia Mahmoud Ahmed Essousi, Houda Chrouda, Amani Alhaidari, Laila M. Jaffrezic-Renault, Nicole Barhoumi, Houcine Sensors (Basel) Article To protect consumers from risks related to overexposure to sulfadiazine, total residues of this antibacterial agent in animal-origin foodstuffs not exceed international regulations. To this end, a new electrochemical sensor based on a molecularly imprinted polymer nanocomposite using overoxidized polypyrrole and copper nanoparticles for the detection of sulfadiazine is elaborated. After optimization of the preparation of the electrochemical sensors, their differential pulse voltammetric signal exhibits an excellent stability and reproducibility at 1.05 V, with a large linear range between 10(−9) and 10(−5) mol L(−1) and a low detection limit of 3.1 × 10(−10) mol L(−1). The produced sulfadiazine sensor was successfully tested in real milk samples. The combination of the properties of the electrical conduction of copper nanoparticles with the properties of the preconcentration of the molecularly imprinted overoxidized polypyrrole allows for the highly sensitive detection of sulfadiazine, even in real milk samples. This strategy is new and leads to the lowest detection limit yet achieved, compared to those of the previously published sulfadiazine electrochemical sensors. MDPI 2023-01-22 /pmc/articles/PMC9919664/ /pubmed/36772311 http://dx.doi.org/10.3390/s23031270 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Elamin, Manahil Babiker
Ali, Shazalia Mahmoud Ahmed
Essousi, Houda
Chrouda, Amani
Alhaidari, Laila M.
Jaffrezic-Renault, Nicole
Barhoumi, Houcine
An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite
title An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite
title_full An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite
title_fullStr An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite
title_full_unstemmed An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite
title_short An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite
title_sort electrochemical sensor for sulfadiazine determination based on a copper nanoparticles/molecularly imprinted overoxidized polypyrrole composite
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919664/
https://www.ncbi.nlm.nih.gov/pubmed/36772311
http://dx.doi.org/10.3390/s23031270
work_keys_str_mv AT elaminmanahilbabiker anelectrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT alishazaliamahmoudahmed anelectrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT essousihouda anelectrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT chroudaamani anelectrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT alhaidarilailam anelectrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT jaffrezicrenaultnicole anelectrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT barhoumihoucine anelectrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT elaminmanahilbabiker electrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT alishazaliamahmoudahmed electrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT essousihouda electrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT chroudaamani electrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT alhaidarilailam electrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT jaffrezicrenaultnicole electrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite
AT barhoumihoucine electrochemicalsensorforsulfadiazinedeterminationbasedonacoppernanoparticlesmolecularlyimprintedoveroxidizedpolypyrrolecomposite