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Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions

Radical reactions are powerful in creating carbon–carbon and carbon–heteroatom bonds. Designing one-pot radical reactions with cascade transformations to assemble the cyclic skeletons with two new functional groups is both synthetically and operationally efficient. Summarized in this paper is the re...

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Detalles Bibliográficos
Autores principales: Zhi, Sanjun, Yao, Hongjun, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919800/
https://www.ncbi.nlm.nih.gov/pubmed/36770814
http://dx.doi.org/10.3390/molecules28031145
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author Zhi, Sanjun
Yao, Hongjun
Zhang, Wei
author_facet Zhi, Sanjun
Yao, Hongjun
Zhang, Wei
author_sort Zhi, Sanjun
collection PubMed
description Radical reactions are powerful in creating carbon–carbon and carbon–heteroatom bonds. Designing one-pot radical reactions with cascade transformations to assemble the cyclic skeletons with two new functional groups is both synthetically and operationally efficient. Summarized in this paper is the recent development of reactions involving radical addition and cyclization of dienes, diynes, enynes, as well as arene-bridged and arene-terminated compounds for the preparation of difunctionalization cyclic compounds. Reactions carried out with radical initiators, transition metal-catalysis, photoredox, and electrochemical conditions are included.
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spelling pubmed-99198002023-02-12 Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions Zhi, Sanjun Yao, Hongjun Zhang, Wei Molecules Review Radical reactions are powerful in creating carbon–carbon and carbon–heteroatom bonds. Designing one-pot radical reactions with cascade transformations to assemble the cyclic skeletons with two new functional groups is both synthetically and operationally efficient. Summarized in this paper is the recent development of reactions involving radical addition and cyclization of dienes, diynes, enynes, as well as arene-bridged and arene-terminated compounds for the preparation of difunctionalization cyclic compounds. Reactions carried out with radical initiators, transition metal-catalysis, photoredox, and electrochemical conditions are included. MDPI 2023-01-23 /pmc/articles/PMC9919800/ /pubmed/36770814 http://dx.doi.org/10.3390/molecules28031145 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhi, Sanjun
Yao, Hongjun
Zhang, Wei
Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions
title Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions
title_full Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions
title_fullStr Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions
title_full_unstemmed Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions
title_short Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions
title_sort difunctionalization of dienes, enynes and related compounds via sequential radical addition and cyclization reactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919800/
https://www.ncbi.nlm.nih.gov/pubmed/36770814
http://dx.doi.org/10.3390/molecules28031145
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