Potent Inhibitory Activity of Natural Product Anaephene B and Analogues against Leishmania tarentolae In Vitro

In this study, a specific alkylphenol natural product, anaephene B, and its unique synthesized derivatives were tested for their inhibitory effect on the protozoan parasite Leishmania tarentolae. In a series of cell viability tests and enzyme assays, these test compounds have produced interesting results with regard to their antibiotic effect, showing similar potency against L. tarentolae as they do against drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). All compounds tested in this study have shown the ability to completely inhibit our model system, L. tarentolae, in vitro. This study helps increase our understanding of the structure-activity relationship (SAR) between anaephene B and its analogues for a new class of potential pharmaceuticals for the treatment of Leishmania infections.