Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity

This review surveys the major structural features in various groups of small molecules that are considered to be antioxidants, including natural and synthetic compounds alike. Recent advances in the strategic modification of known small molecule antioxidants are also described. The highlight is plac...

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Detalles Bibliográficos
Autores principales: Charlton, Nathan C., Mastyugin, Maxim, Török, Béla, Török, Marianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920158/
https://www.ncbi.nlm.nih.gov/pubmed/36770724
http://dx.doi.org/10.3390/molecules28031057
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author Charlton, Nathan C.
Mastyugin, Maxim
Török, Béla
Török, Marianna
author_facet Charlton, Nathan C.
Mastyugin, Maxim
Török, Béla
Török, Marianna
author_sort Charlton, Nathan C.
collection PubMed
description This review surveys the major structural features in various groups of small molecules that are considered to be antioxidants, including natural and synthetic compounds alike. Recent advances in the strategic modification of known small molecule antioxidants are also described. The highlight is placed on changing major physicochemical parameters, including log p, bond dissociation energy, ionization potential, and others which result in improved antioxidant activity.
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spelling pubmed-99201582023-02-12 Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity Charlton, Nathan C. Mastyugin, Maxim Török, Béla Török, Marianna Molecules Review This review surveys the major structural features in various groups of small molecules that are considered to be antioxidants, including natural and synthetic compounds alike. Recent advances in the strategic modification of known small molecule antioxidants are also described. The highlight is placed on changing major physicochemical parameters, including log p, bond dissociation energy, ionization potential, and others which result in improved antioxidant activity. MDPI 2023-01-20 /pmc/articles/PMC9920158/ /pubmed/36770724 http://dx.doi.org/10.3390/molecules28031057 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Charlton, Nathan C.
Mastyugin, Maxim
Török, Béla
Török, Marianna
Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity
title Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity
title_full Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity
title_fullStr Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity
title_full_unstemmed Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity
title_short Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity
title_sort structural features of small molecule antioxidants and strategic modifications to improve potential bioactivity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920158/
https://www.ncbi.nlm.nih.gov/pubmed/36770724
http://dx.doi.org/10.3390/molecules28031057
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