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Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies

The circadian system in the human body responds to daily environmental changes to optimise behaviour according to the biological clock and also influences various physiological processes. The suprachiasmatic nuclei are located in the anterior hypothalamus of the brain, and they synchronise to the 24...

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Autores principales: Juliana, Norsham, Azmi, Liyana, Effendy, Nadia Mohd, Mohd Fahmi Teng, Nur Islami, Abu, Izuddin Fahmy, Abu Bakar, Nur Nabilah, Azmani, Sahar, Yazit, Noor Anisah Abu, Kadiman, Suhaini, Das, Srijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920183/
https://www.ncbi.nlm.nih.gov/pubmed/36771440
http://dx.doi.org/10.3390/nu15030734
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author Juliana, Norsham
Azmi, Liyana
Effendy, Nadia Mohd
Mohd Fahmi Teng, Nur Islami
Abu, Izuddin Fahmy
Abu Bakar, Nur Nabilah
Azmani, Sahar
Yazit, Noor Anisah Abu
Kadiman, Suhaini
Das, Srijit
author_facet Juliana, Norsham
Azmi, Liyana
Effendy, Nadia Mohd
Mohd Fahmi Teng, Nur Islami
Abu, Izuddin Fahmy
Abu Bakar, Nur Nabilah
Azmani, Sahar
Yazit, Noor Anisah Abu
Kadiman, Suhaini
Das, Srijit
author_sort Juliana, Norsham
collection PubMed
description The circadian system in the human body responds to daily environmental changes to optimise behaviour according to the biological clock and also influences various physiological processes. The suprachiasmatic nuclei are located in the anterior hypothalamus of the brain, and they synchronise to the 24 h light/dark cycle. Human physiological functions are highly dependent on the regulation of the internal circadian clock. Skeletal muscles comprise the largest collection of peripheral clocks in the human body. Both central and peripheral clocks regulate the interaction between the musculoskeletal system and energy metabolism. The skeletal muscle circadian clock plays a vital role in lipid and glucose metabolism. The pathogenesis of osteoporosis is related to an alteration in the circadian rhythm. In the present review, we discuss the disturbance of the circadian rhythm and its resultant effect on the musculoskeletal system. We also discuss the nutritional strategies that are potentially effective in maintaining the system’s homeostasis. Active collaborations between nutritionists and physiologists in the field of chronobiological and chrononutrition will further clarify these interactions. This review may be necessary for successful interventions in reducing morbidity and mortality resulting from musculoskeletal disturbances.
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spelling pubmed-99201832023-02-12 Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies Juliana, Norsham Azmi, Liyana Effendy, Nadia Mohd Mohd Fahmi Teng, Nur Islami Abu, Izuddin Fahmy Abu Bakar, Nur Nabilah Azmani, Sahar Yazit, Noor Anisah Abu Kadiman, Suhaini Das, Srijit Nutrients Review The circadian system in the human body responds to daily environmental changes to optimise behaviour according to the biological clock and also influences various physiological processes. The suprachiasmatic nuclei are located in the anterior hypothalamus of the brain, and they synchronise to the 24 h light/dark cycle. Human physiological functions are highly dependent on the regulation of the internal circadian clock. Skeletal muscles comprise the largest collection of peripheral clocks in the human body. Both central and peripheral clocks regulate the interaction between the musculoskeletal system and energy metabolism. The skeletal muscle circadian clock plays a vital role in lipid and glucose metabolism. The pathogenesis of osteoporosis is related to an alteration in the circadian rhythm. In the present review, we discuss the disturbance of the circadian rhythm and its resultant effect on the musculoskeletal system. We also discuss the nutritional strategies that are potentially effective in maintaining the system’s homeostasis. Active collaborations between nutritionists and physiologists in the field of chronobiological and chrononutrition will further clarify these interactions. This review may be necessary for successful interventions in reducing morbidity and mortality resulting from musculoskeletal disturbances. MDPI 2023-02-01 /pmc/articles/PMC9920183/ /pubmed/36771440 http://dx.doi.org/10.3390/nu15030734 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Juliana, Norsham
Azmi, Liyana
Effendy, Nadia Mohd
Mohd Fahmi Teng, Nur Islami
Abu, Izuddin Fahmy
Abu Bakar, Nur Nabilah
Azmani, Sahar
Yazit, Noor Anisah Abu
Kadiman, Suhaini
Das, Srijit
Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies
title Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies
title_full Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies
title_fullStr Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies
title_full_unstemmed Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies
title_short Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies
title_sort effect of circadian rhythm disturbance on the human musculoskeletal system and the importance of nutritional strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920183/
https://www.ncbi.nlm.nih.gov/pubmed/36771440
http://dx.doi.org/10.3390/nu15030734
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