Cargando…

Icaritin Derivative IC2 Induces Cytoprotective Autophagy of Breast Cancer Cells via SCD1 Inhibition

Breast cancer is one of the most prevalent malignancies and the leading cause of cancer-associated mortality in China. Icaritin (ICT), a prenyl flavonoid derived from the Epimedium Genus, has been proven to inhibit the proliferation and stemness of breast cancer cells. Our previous study demonstrate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yi-Xuan, Jin, Yi-Yuan, Wang, Jie, Zhao, Zi-Cheng, Xue, Ke-Wen, Xiong, He, Che, Hui-Lian, Ge, Yun-Jun, Wu, Guo-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920188/ https://www.ncbi.nlm.nih.gov/pubmed/36770781 http://dx.doi.org/10.3390/molecules28031109

Ejemplares similares

Identification of icaritin derivative IC2 as an SCD-1 inhibitor with anti-breast cancer properties through induction of cell apoptosis
por: Yang, Chen, et al.
Publicado: (2022)

Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK
por: Wu, Yue, et al.
Publicado: (2021)

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
por: Li, Haowen, et al.
Publicado: (2020)

Cytoprotective roles for autophagy
por: Moreau, Kevin, et al.
Publicado: (2010)

Investigating the effect of Icaritin on hepatocellular carcinoma based on network pharmacology
por: Xue, Zhong, et al.
Publicado: (2023)

Icaritin inhibits decidualization of endometrial stromal cells
por: Le, Aiwen, et al.
Publicado: (2017)

AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity
por: Zhou, Chunxian, et al.
Publicado: (2017)

Icaritin: A Novel Natural Candidate for Hematological Malignancies Therapy
por: Yang, Xiao-Jing, et al.
Publicado: (2019)

SCD1, autophagy and cancer: implications for therapy
por: Ascenzi, Francesca, et al.
Publicado: (2021)

A Novel Semisynthetic Molecule Icaritin Stimulates Osteogenic Differentiation and Inhibits Adipogenesis of Mesenchymal Stem Cells
por: Sheng, Hui, et al.
Publicado: (2013)

Nanomedicine‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma
por: Lu, Yi, et al.
Publicado: (2022)

Icaritin, an Exogenous Phytomolecule, Enhances Osteogenesis but Not Angiogenesis—An In Vitro Efficacy Study
por: Yao, Dong, et al.
Publicado: (2012)

Icaritin Causes Sustained ERK1/2 Activation and Induces Apoptosis in Human Endometrial Cancer Cells
por: Tong, Jing-Shan, et al.
Publicado: (2011)

Correction to: Nanomedicine‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma
por: Lu, Yi, et al.
Publicado: (2023)

Icaritin Induces Anti-tumor Immune Responses in Hepatocellular Carcinoma by Inhibiting Splenic Myeloid-Derived Suppressor Cell Generation
por: Tao, Huimin, et al.
Publicado: (2021)

Targeting Cytoprotective Autophagy to Enhance Anticancer Therapies
por: Xiao, Malina, et al.
Publicado: (2021)

Icaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma
por: Wu, Ting, et al.
Publicado: (2015)

Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis
por: Huang, Jun-ming, et al.
Publicado: (2023)

A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner
por: Zhang, Ge, et al.
Publicado: (2009)

The Antiosteoporotic Activity of Central-Icaritin (CIT) on Bone Metabolism of Ovariectomized Rats
por: Jiang, Jun, et al.
Publicado: (2014)

Effect of icaritin on autophagy-related protein expression in TDP-43-transfected SH-SY5Y cells
por: Zhou, Yanjun, et al.
Publicado: (2022)

Autophagy in human articular chondrocytes is cytoprotective following glucocorticoid stimulation
por: LIU, NING, et al.
Publicado: (2014)

EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells
por: Han, Weidong, et al.
Publicado: (2011)

Pharmacokinetics and metabolism of icaritin in rats by UPLC‐MS/MS
por: Huang, Zhen‐Wu, et al.
Publicado: (2019)

The Cytoprotective Role of Autophagy in Response to BRAF-Targeted Therapies
por: Elshazly, Ahmed M., et al.
Publicado: (2023)

Icaritin inhibits CDK2 expression and activity to interfere with tumor progression
por: Zhang, Chao, et al.
Publicado: (2022)

Antioxidation and Cytoprotection of Acteoside and Its Derivatives: Comparison and Mechanistic Chemistry
por: Li, Xican, et al.
Publicado: (2018)

Icaritin alleviates docetaxel‐induced skin injury by suppressing reactive oxygen species via estrogen receptors
por: Zou, Jie, et al.
Publicado: (2021)

Icaritin Provokes Serum Thrombopoietin and Downregulates Thrombopoietin/MPL of the Bone Marrow in a Mouse Model of Immune Thrombocytopenia
por: Zhang, Ke, et al.
Publicado: (2018)

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells
por: Song, Ping, et al.
Publicado: (2015)

ICS II protects against cardiac hypertrophy by regulating metabolic remodelling, not by inhibiting autophagy
por: Han, Dongjian, et al.
Publicado: (2020)

Cytoprotective Role of Heme Oxygenase-1 in Cancer Chemoresistance: Focus on Antioxidant, Antiapoptotic, and Pro-Autophagy Properties
por: Wang, Huan, et al.
Publicado: (2023)

Icaritin Provides Neuroprotection in Parkinson’s Disease by Attenuating Neuroinflammation, Oxidative Stress, and Energy Deficiency
por: Wu, Hao, et al.
Publicado: (2021)

Highly efficient bioconversion of icariin to icaritin by whole-cell catalysis
por: Lin, Yu, et al.
Publicado: (2023)

Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma
por: Li, Hui, et al.
Publicado: (2021)

Cytoprotective, Cytotoxic and Cytostatic Roles of Autophagy in Response to BET Inhibitors
por: Elshazly, Ahmed M., et al.
Publicado: (2023)

MiR-1908/EXO1 and MiR-203a/FOS, regulated by scd1, are associated with fracture risk and bone health in postmenopausal diabetic women
por: Chen, Yi-sheng, et al.
Publicado: (2020)

Cytotoxic Effect of Icaritin and Its Mechanisms in Inducing Apoptosis in Human Burkitt Lymphoma Cell Line
por: Li, Zi-Jian, et al.
Publicado: (2014)

Natural product-derived icaritin exerts anti-glioblastoma effects by positively modulating estrogen receptor β
por: Li, Xiaowen, et al.
Publicado: (2020)

Dityrosine suppresses the cytoprotective action of thyroid hormone T3 via inhibiting thyroid hormone receptor-mediated transcriptional activation
por: Ding, Yin-Yi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_n3jq3bk6thod5lfj18bs4rf7fm