Cargando…

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators

Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent agonists, allosteric activating PAMs and neutral or silent allosteric modulators are compounds capable of modulating the nicotinic receptor by interacting at allosteric modulatory sites distinct from the orthosteric...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manetti, Dina, Dei, Silvia, Arias, Hugo R., Braconi, Laura, Gabellini, Alessio, Teodori, Elisabetta, Romanelli, Maria Novella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920195/ https://www.ncbi.nlm.nih.gov/pubmed/36770942 http://dx.doi.org/10.3390/molecules28031270

Ejemplares similares

Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators
por: Dei, Silvia, et al.
Publicado: (2019)

New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators
por: Chiaramonte, Niccolò, et al.
Publicado: (2022)

Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells †
por: Teodori, Elisabetta, et al.
Publicado: (2020)

New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells
por: Braconi, Laura, et al.
Publicado: (2022)

Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4‐Substituted Quinazoline Derivatives
por: Braconi, Laura, et al.
Publicado: (2022)

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers
por: Braconi, Laura, et al.
Publicado: (2020)

Desformylflustrabromine, a positive allosteric modulator of α4β2-containing nicotinic acetylcholine receptors, enhances cognition in rats
por: Nikiforuk, Agnieszka, et al.
Publicado: (2020)

Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine(1)
por: Chiaramonte, Niccolò, et al.
Publicado: (2020)

The Antinociceptive Activity of (E)-3-(thiophen-2-yl)-N-(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)-N-methyl-N-(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor
por: Arias, Hugo R., et al.
Publicado: (2023)

HCN Channels Modulators: The Need for Selectivity
por: Romanelli, Maria Novella, et al.
Publicado: (2016)

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107
por: Mizrachi, Tehila, et al.
Publicado: (2021)

Menthol Suppresses Nicotinic Acetylcholine Receptor Functioning in Sensory Neurons via Allosteric Modulation
por: Hans, M., et al.
Publicado: (2012)

Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation
por: Mohamed, Tasnim S., et al.
Publicado: (2015)

The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors
por: Chatzidaki, Anna, et al.
Publicado: (2015)

Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors
por: Choudhary, Shivani, et al.
Publicado: (2018)

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
por: Li, Qimeng, et al.
Publicado: (2023)

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models
por: Kryukova, Elena V., et al.
Publicado: (2018)

Allosteric Modulation of Muscarinic Acetylcholine Receptors
por: Gregory, Karen J, et al.
Publicado: (2007)

Allosteric Modulation of Muscarinic Acetylcholine Receptors
por: Jakubík, Jan, et al.
Publicado: (2010)

Nicotinic acetylcholine receptors modulate osteoclastogenesis
por: Mandl, Peter, et al.
Publicado: (2016)

Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model
por: Newcombe, Joseph, et al.
Publicado: (2018)

An allosteric link connecting the lipid-protein interface to the gating of the nicotinic acetylcholine receptor
por: Domville, Jaimee A., et al.
Publicado: (2018)

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein
por: Delbart, Florian, et al.
Publicado: (2018)

Structurally Similar Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects
por: Gill-Thind, JasKiran K., et al.
Publicado: (2015)

Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor
por: Changeux, Jean-Pierre
Publicado: (2020)

Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors
por: Ho, Thao NT, et al.
Publicado: (2023)

Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor
por: Smelt, Charles L.C., et al.
Publicado: (2018)

Simultaneous Degradation Study of Isomers in Human Plasma by HPLC-MS/MS and Application of LEDA Algorithm for Their Characterization
por: Pallecchi, Marco, et al.
Publicado: (2022)

Isomers Recognition in HPLC-MS/MS Analysis of Human Plasma Samples by Using an Ion Trap Supported by a Linear Equations-Based Algorithm
por: Pallecchi, Marco, et al.
Publicado: (2023)

Activation and allosteric modulation of a muscarinic acetylcholine receptor
por: Kruse, Andrew C., et al.
Publicado: (2013)

Structure-based discovery of selective positive allosteric modulators of antagonists for the M(2) muscarinic acetylcholine receptor
por: Korczynska, Magdalena, et al.
Publicado: (2018)

Allosterism of Nicotinic Acetylcholine Receptors: Therapeutic Potential for Neuroinflammation Underlying Brain Trauma and Degenerative Disorders
por: Mitra, Swarup, et al.
Publicado: (2020)

Allosteric inhibition of muscle-type nicotinic acetylcholine receptors by a neuromuscular blocking agent pancuronium
por: Sakata, Souhei, et al.
Publicado: (2023)

Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors
por: Chiaramonte, Niccolò, et al.
Publicado: (2018)

Type I-like behavior of the type II α7 nicotinic acetylcholine receptor positive allosteric modulator A-867744
por: Pesti, Krisztina, et al.
Publicado: (2019)

Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury
por: Titus, David J., et al.
Publicado: (2019)

Positive Allosteric Modulation of Alpha7 Nicotinic Acetylcholine Receptors Transiently Improves Memory but Aggravates Inflammation in LPS-Treated Mice
por: Lykhmus, Olena, et al.
Publicado: (2020)

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine
por: Schapira, Matthieu, et al.
Publicado: (2002)

Contrasting Properties of α7-Selective Orthosteric and Allosteric Agonists Examined on Native Nicotinic Acetylcholine Receptors
por: Gill, JasKiran K., et al.
Publicado: (2013)

Corrigendum: Positive Allosteric Modulation of Alpha7 Nicotinic Acetylcholine Receptors Transiently Improves Memory but Aggravates Inflammation in LPS-Treated Mice
por: Lykhmus, Olena, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ebh287lgk2i4koqkl1j0jh18e7