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The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism
The prevalence of obesity and related metabolic diseases has increased dramatically worldwide. As obesity progresses, various lipid species accumulate in ectopic tissues. Amongst them, ceramides—a deleterious sphingolipid species—accumulate and cause lipotoxicity and metabolic disturbances. Dysregul...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920427/ https://www.ncbi.nlm.nih.gov/pubmed/36771408 http://dx.doi.org/10.3390/nu15030703 |
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author | Kim, Eunkyeong Jeon, Sookyoung |
author_facet | Kim, Eunkyeong Jeon, Sookyoung |
author_sort | Kim, Eunkyeong |
collection | PubMed |
description | The prevalence of obesity and related metabolic diseases has increased dramatically worldwide. As obesity progresses, various lipid species accumulate in ectopic tissues. Amongst them, ceramides—a deleterious sphingolipid species—accumulate and cause lipotoxicity and metabolic disturbances. Dysregulated ceramide metabolism appears to be a key feature in the pathogenesis of obesity-related metabolic diseases. Notably, dietary modification might have an impact on modulating ceramide metabolism. Phytochemicals are plant-derived compounds with various physiological properties, which have been shown to protect against obesity-related metabolic diseases. In this review, we aim to examine the impact of a myriad of phytochemicals and their dietary sources in altering ceramide deposition and ceramide-related metabolism from in vitro, in vivo, and human clinical/epidemiological studies. This review discusses how numerous phytochemicals are able to alleviate ceramide-induced metabolic defects and reduce the risk of obesity-related metabolic diseases via diverse mechanisms. |
format | Online Article Text |
id | pubmed-9920427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99204272023-02-12 The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism Kim, Eunkyeong Jeon, Sookyoung Nutrients Review The prevalence of obesity and related metabolic diseases has increased dramatically worldwide. As obesity progresses, various lipid species accumulate in ectopic tissues. Amongst them, ceramides—a deleterious sphingolipid species—accumulate and cause lipotoxicity and metabolic disturbances. Dysregulated ceramide metabolism appears to be a key feature in the pathogenesis of obesity-related metabolic diseases. Notably, dietary modification might have an impact on modulating ceramide metabolism. Phytochemicals are plant-derived compounds with various physiological properties, which have been shown to protect against obesity-related metabolic diseases. In this review, we aim to examine the impact of a myriad of phytochemicals and their dietary sources in altering ceramide deposition and ceramide-related metabolism from in vitro, in vivo, and human clinical/epidemiological studies. This review discusses how numerous phytochemicals are able to alleviate ceramide-induced metabolic defects and reduce the risk of obesity-related metabolic diseases via diverse mechanisms. MDPI 2023-01-30 /pmc/articles/PMC9920427/ /pubmed/36771408 http://dx.doi.org/10.3390/nu15030703 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kim, Eunkyeong Jeon, Sookyoung The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism |
title | The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism |
title_full | The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism |
title_fullStr | The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism |
title_full_unstemmed | The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism |
title_short | The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism |
title_sort | impact of phytochemicals in obesity-related metabolic diseases: focus on ceramide metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920427/ https://www.ncbi.nlm.nih.gov/pubmed/36771408 http://dx.doi.org/10.3390/nu15030703 |
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