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Nutritional Interventions during Chemotherapy for Pancreatic Cancer: A Systematic Review of Prospective Studies

Background: Pancreatic cancer incidence is growing, but the prognosis for survival is still poor. Patients with pancreatic cancer often suffer from malnutrition and sarcopenia, two clinical conditions that negatively impact oncological clinical outcomes. The aim of this systematic review was to anal...

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Autores principales: Cintoni, Marco, Grassi, Futura, Palombaro, Marta, Rinninella, Emanuele, Pulcini, Gabriele, Di Donato, Agnese, Salvatore, Lisa, Quero, Giuseppe, Tortora, Giampaolo, Alfieri, Sergio, Gasbarrini, Antonio, Mele, Maria Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920549/
https://www.ncbi.nlm.nih.gov/pubmed/36771433
http://dx.doi.org/10.3390/nu15030727
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author Cintoni, Marco
Grassi, Futura
Palombaro, Marta
Rinninella, Emanuele
Pulcini, Gabriele
Di Donato, Agnese
Salvatore, Lisa
Quero, Giuseppe
Tortora, Giampaolo
Alfieri, Sergio
Gasbarrini, Antonio
Mele, Maria Cristina
author_facet Cintoni, Marco
Grassi, Futura
Palombaro, Marta
Rinninella, Emanuele
Pulcini, Gabriele
Di Donato, Agnese
Salvatore, Lisa
Quero, Giuseppe
Tortora, Giampaolo
Alfieri, Sergio
Gasbarrini, Antonio
Mele, Maria Cristina
author_sort Cintoni, Marco
collection PubMed
description Background: Pancreatic cancer incidence is growing, but the prognosis for survival is still poor. Patients with pancreatic cancer often suffer from malnutrition and sarcopenia, two clinical conditions that negatively impact oncological clinical outcomes. The aim of this systematic review was to analyze the impact of different nutritional interventions on clinical outcomes in patients with pancreatic cancer during chemotherapy. Methods: A systematic review of MedLine, EMBASE, and Web of Science was carried out in December 2022, identifying 5704 articles. Titles and abstracts of all records were screened for eligibility based on inclusion criteria, and nine articles were included. Results: All nine articles included were prospective studies, but a meta-analysis could not be performed due to heterogenicity in nutritional intervention. This Systematic Review shows an improvement in Quality of Life, nutritional status, body composition, oral intake, and Karnofsky Performance Status, following nutritional interventions. Conclusions: This Systematic Review in pancreatic cancer patients during chemotherapies does not allow one to draw firm conclusions. However, nutritional support in pancreatic cancer patients is advisable to ameliorate oncological care. Further well-designed prospective studies are needed to identify nutritional support’s real impact and to establish a reliable way to improve nutritional status of pancreatic cancer patients during chemotherapy.
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spelling pubmed-99205492023-02-12 Nutritional Interventions during Chemotherapy for Pancreatic Cancer: A Systematic Review of Prospective Studies Cintoni, Marco Grassi, Futura Palombaro, Marta Rinninella, Emanuele Pulcini, Gabriele Di Donato, Agnese Salvatore, Lisa Quero, Giuseppe Tortora, Giampaolo Alfieri, Sergio Gasbarrini, Antonio Mele, Maria Cristina Nutrients Systematic Review Background: Pancreatic cancer incidence is growing, but the prognosis for survival is still poor. Patients with pancreatic cancer often suffer from malnutrition and sarcopenia, two clinical conditions that negatively impact oncological clinical outcomes. The aim of this systematic review was to analyze the impact of different nutritional interventions on clinical outcomes in patients with pancreatic cancer during chemotherapy. Methods: A systematic review of MedLine, EMBASE, and Web of Science was carried out in December 2022, identifying 5704 articles. Titles and abstracts of all records were screened for eligibility based on inclusion criteria, and nine articles were included. Results: All nine articles included were prospective studies, but a meta-analysis could not be performed due to heterogenicity in nutritional intervention. This Systematic Review shows an improvement in Quality of Life, nutritional status, body composition, oral intake, and Karnofsky Performance Status, following nutritional interventions. Conclusions: This Systematic Review in pancreatic cancer patients during chemotherapies does not allow one to draw firm conclusions. However, nutritional support in pancreatic cancer patients is advisable to ameliorate oncological care. Further well-designed prospective studies are needed to identify nutritional support’s real impact and to establish a reliable way to improve nutritional status of pancreatic cancer patients during chemotherapy. MDPI 2023-02-01 /pmc/articles/PMC9920549/ /pubmed/36771433 http://dx.doi.org/10.3390/nu15030727 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Cintoni, Marco
Grassi, Futura
Palombaro, Marta
Rinninella, Emanuele
Pulcini, Gabriele
Di Donato, Agnese
Salvatore, Lisa
Quero, Giuseppe
Tortora, Giampaolo
Alfieri, Sergio
Gasbarrini, Antonio
Mele, Maria Cristina
Nutritional Interventions during Chemotherapy for Pancreatic Cancer: A Systematic Review of Prospective Studies
title Nutritional Interventions during Chemotherapy for Pancreatic Cancer: A Systematic Review of Prospective Studies
title_full Nutritional Interventions during Chemotherapy for Pancreatic Cancer: A Systematic Review of Prospective Studies
title_fullStr Nutritional Interventions during Chemotherapy for Pancreatic Cancer: A Systematic Review of Prospective Studies
title_full_unstemmed Nutritional Interventions during Chemotherapy for Pancreatic Cancer: A Systematic Review of Prospective Studies
title_short Nutritional Interventions during Chemotherapy for Pancreatic Cancer: A Systematic Review of Prospective Studies
title_sort nutritional interventions during chemotherapy for pancreatic cancer: a systematic review of prospective studies
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920549/
https://www.ncbi.nlm.nih.gov/pubmed/36771433
http://dx.doi.org/10.3390/nu15030727
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