Cargando…
The Association of Serum and Dietary Magnesium with Depressive Symptoms
Depression is a leading cause of the global burden of disease and has a multifactorial etiology that includes nutrients. Magnesium status has been associated with depression with inconclusive results. The impact of chronic latent magnesium deficiency (CLMD, 0.75 ≤ serum magnesium < 0.85 mmol/L) o...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920676/ https://www.ncbi.nlm.nih.gov/pubmed/36771478 http://dx.doi.org/10.3390/nu15030774 |
_version_ | 1784887128412389376 |
---|---|
author | Chou, Ming-Hui Yang, Yen Kuang Wang, Jung-Der Lin, Chung-Ying Lin, Sheng-Hsiang |
author_facet | Chou, Ming-Hui Yang, Yen Kuang Wang, Jung-Der Lin, Chung-Ying Lin, Sheng-Hsiang |
author_sort | Chou, Ming-Hui |
collection | PubMed |
description | Depression is a leading cause of the global burden of disease and has a multifactorial etiology that includes nutrients. Magnesium status has been associated with depression with inconclusive results. The impact of chronic latent magnesium deficiency (CLMD, 0.75 ≤ serum magnesium < 0.85 mmol/L) on depression has not yet been investigated. We assessed the association between serum magnesium levels/dietary magnesium intake and depressive symptoms by analyzing nationally representative data from Taiwan (Nutrition and Health Survey in Taiwan, NAHSIT). We used the 5-item Brief Symptom Rating Scale to measure depressive symptoms. Subgroup analysis by sex was also performed. Serum magnesium levels had a low correlation with dietary magnesium intake. Higher serum magnesium levels were associated with lower depressive scores and a lower risk of depressive symptoms, but dietary magnesium intake showed no association. Sex differences were found. Compared with subjects with serum magnesium <0.75 mmol/L, those with ≥0.85 mmol/L had lower depressive scores. In conclusion, serum magnesium was inversely associated with depressive symptoms, but dietary magnesium intake was not. Subjects with CLMD showed similar depressive scores and were at a similar risk of depressive symptoms to those with serum magnesium < 0.75 mmol/L. CLMD should be considered while assessing the association between magnesium status and depressive symptoms. |
format | Online Article Text |
id | pubmed-9920676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99206762023-02-12 The Association of Serum and Dietary Magnesium with Depressive Symptoms Chou, Ming-Hui Yang, Yen Kuang Wang, Jung-Der Lin, Chung-Ying Lin, Sheng-Hsiang Nutrients Article Depression is a leading cause of the global burden of disease and has a multifactorial etiology that includes nutrients. Magnesium status has been associated with depression with inconclusive results. The impact of chronic latent magnesium deficiency (CLMD, 0.75 ≤ serum magnesium < 0.85 mmol/L) on depression has not yet been investigated. We assessed the association between serum magnesium levels/dietary magnesium intake and depressive symptoms by analyzing nationally representative data from Taiwan (Nutrition and Health Survey in Taiwan, NAHSIT). We used the 5-item Brief Symptom Rating Scale to measure depressive symptoms. Subgroup analysis by sex was also performed. Serum magnesium levels had a low correlation with dietary magnesium intake. Higher serum magnesium levels were associated with lower depressive scores and a lower risk of depressive symptoms, but dietary magnesium intake showed no association. Sex differences were found. Compared with subjects with serum magnesium <0.75 mmol/L, those with ≥0.85 mmol/L had lower depressive scores. In conclusion, serum magnesium was inversely associated with depressive symptoms, but dietary magnesium intake was not. Subjects with CLMD showed similar depressive scores and were at a similar risk of depressive symptoms to those with serum magnesium < 0.75 mmol/L. CLMD should be considered while assessing the association between magnesium status and depressive symptoms. MDPI 2023-02-02 /pmc/articles/PMC9920676/ /pubmed/36771478 http://dx.doi.org/10.3390/nu15030774 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chou, Ming-Hui Yang, Yen Kuang Wang, Jung-Der Lin, Chung-Ying Lin, Sheng-Hsiang The Association of Serum and Dietary Magnesium with Depressive Symptoms |
title | The Association of Serum and Dietary Magnesium with Depressive Symptoms |
title_full | The Association of Serum and Dietary Magnesium with Depressive Symptoms |
title_fullStr | The Association of Serum and Dietary Magnesium with Depressive Symptoms |
title_full_unstemmed | The Association of Serum and Dietary Magnesium with Depressive Symptoms |
title_short | The Association of Serum and Dietary Magnesium with Depressive Symptoms |
title_sort | association of serum and dietary magnesium with depressive symptoms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920676/ https://www.ncbi.nlm.nih.gov/pubmed/36771478 http://dx.doi.org/10.3390/nu15030774 |
work_keys_str_mv | AT chouminghui theassociationofserumanddietarymagnesiumwithdepressivesymptoms AT yangyenkuang theassociationofserumanddietarymagnesiumwithdepressivesymptoms AT wangjungder theassociationofserumanddietarymagnesiumwithdepressivesymptoms AT linchungying theassociationofserumanddietarymagnesiumwithdepressivesymptoms AT linshenghsiang theassociationofserumanddietarymagnesiumwithdepressivesymptoms AT chouminghui associationofserumanddietarymagnesiumwithdepressivesymptoms AT yangyenkuang associationofserumanddietarymagnesiumwithdepressivesymptoms AT wangjungder associationofserumanddietarymagnesiumwithdepressivesymptoms AT linchungying associationofserumanddietarymagnesiumwithdepressivesymptoms AT linshenghsiang associationofserumanddietarymagnesiumwithdepressivesymptoms |