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The Association of Serum and Dietary Magnesium with Depressive Symptoms

Depression is a leading cause of the global burden of disease and has a multifactorial etiology that includes nutrients. Magnesium status has been associated with depression with inconclusive results. The impact of chronic latent magnesium deficiency (CLMD, 0.75 ≤ serum magnesium < 0.85 mmol/L) o...

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Autores principales: Chou, Ming-Hui, Yang, Yen Kuang, Wang, Jung-Der, Lin, Chung-Ying, Lin, Sheng-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920676/
https://www.ncbi.nlm.nih.gov/pubmed/36771478
http://dx.doi.org/10.3390/nu15030774
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author Chou, Ming-Hui
Yang, Yen Kuang
Wang, Jung-Der
Lin, Chung-Ying
Lin, Sheng-Hsiang
author_facet Chou, Ming-Hui
Yang, Yen Kuang
Wang, Jung-Der
Lin, Chung-Ying
Lin, Sheng-Hsiang
author_sort Chou, Ming-Hui
collection PubMed
description Depression is a leading cause of the global burden of disease and has a multifactorial etiology that includes nutrients. Magnesium status has been associated with depression with inconclusive results. The impact of chronic latent magnesium deficiency (CLMD, 0.75 ≤ serum magnesium < 0.85 mmol/L) on depression has not yet been investigated. We assessed the association between serum magnesium levels/dietary magnesium intake and depressive symptoms by analyzing nationally representative data from Taiwan (Nutrition and Health Survey in Taiwan, NAHSIT). We used the 5-item Brief Symptom Rating Scale to measure depressive symptoms. Subgroup analysis by sex was also performed. Serum magnesium levels had a low correlation with dietary magnesium intake. Higher serum magnesium levels were associated with lower depressive scores and a lower risk of depressive symptoms, but dietary magnesium intake showed no association. Sex differences were found. Compared with subjects with serum magnesium <0.75 mmol/L, those with ≥0.85 mmol/L had lower depressive scores. In conclusion, serum magnesium was inversely associated with depressive symptoms, but dietary magnesium intake was not. Subjects with CLMD showed similar depressive scores and were at a similar risk of depressive symptoms to those with serum magnesium < 0.75 mmol/L. CLMD should be considered while assessing the association between magnesium status and depressive symptoms.
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spelling pubmed-99206762023-02-12 The Association of Serum and Dietary Magnesium with Depressive Symptoms Chou, Ming-Hui Yang, Yen Kuang Wang, Jung-Der Lin, Chung-Ying Lin, Sheng-Hsiang Nutrients Article Depression is a leading cause of the global burden of disease and has a multifactorial etiology that includes nutrients. Magnesium status has been associated with depression with inconclusive results. The impact of chronic latent magnesium deficiency (CLMD, 0.75 ≤ serum magnesium < 0.85 mmol/L) on depression has not yet been investigated. We assessed the association between serum magnesium levels/dietary magnesium intake and depressive symptoms by analyzing nationally representative data from Taiwan (Nutrition and Health Survey in Taiwan, NAHSIT). We used the 5-item Brief Symptom Rating Scale to measure depressive symptoms. Subgroup analysis by sex was also performed. Serum magnesium levels had a low correlation with dietary magnesium intake. Higher serum magnesium levels were associated with lower depressive scores and a lower risk of depressive symptoms, but dietary magnesium intake showed no association. Sex differences were found. Compared with subjects with serum magnesium <0.75 mmol/L, those with ≥0.85 mmol/L had lower depressive scores. In conclusion, serum magnesium was inversely associated with depressive symptoms, but dietary magnesium intake was not. Subjects with CLMD showed similar depressive scores and were at a similar risk of depressive symptoms to those with serum magnesium < 0.75 mmol/L. CLMD should be considered while assessing the association between magnesium status and depressive symptoms. MDPI 2023-02-02 /pmc/articles/PMC9920676/ /pubmed/36771478 http://dx.doi.org/10.3390/nu15030774 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chou, Ming-Hui
Yang, Yen Kuang
Wang, Jung-Der
Lin, Chung-Ying
Lin, Sheng-Hsiang
The Association of Serum and Dietary Magnesium with Depressive Symptoms
title The Association of Serum and Dietary Magnesium with Depressive Symptoms
title_full The Association of Serum and Dietary Magnesium with Depressive Symptoms
title_fullStr The Association of Serum and Dietary Magnesium with Depressive Symptoms
title_full_unstemmed The Association of Serum and Dietary Magnesium with Depressive Symptoms
title_short The Association of Serum and Dietary Magnesium with Depressive Symptoms
title_sort association of serum and dietary magnesium with depressive symptoms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920676/
https://www.ncbi.nlm.nih.gov/pubmed/36771478
http://dx.doi.org/10.3390/nu15030774
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