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Fabrication, Evaluation, and Antioxidant Properties of Carrier-Free Curcumin Nanoparticles
Curcumin (Cur), a natural hydrophobic polyphenolic compound, exhibits multiple beneficial biological activities. However, low water solubility and relative instability hinder its application in food fields. In this study, carrier-free curcumin nanoparticles (CFC NPs) were prepared by adding the DMSO...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920916/ https://www.ncbi.nlm.nih.gov/pubmed/36770966 http://dx.doi.org/10.3390/molecules28031298 |
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author | Wu, Jinwei Chen, Jiaxin Wei, Zizhan Zhu, Pingchuan Li, Bangda Qing, Qing Chen, Huimin Lin, Weiying Lin, Jianyan Hong, Xuehui Yu, Fei Chen, Xiaodong |
author_facet | Wu, Jinwei Chen, Jiaxin Wei, Zizhan Zhu, Pingchuan Li, Bangda Qing, Qing Chen, Huimin Lin, Weiying Lin, Jianyan Hong, Xuehui Yu, Fei Chen, Xiaodong |
author_sort | Wu, Jinwei |
collection | PubMed |
description | Curcumin (Cur), a natural hydrophobic polyphenolic compound, exhibits multiple beneficial biological activities. However, low water solubility and relative instability hinder its application in food fields. In this study, carrier-free curcumin nanoparticles (CFC NPs) were prepared by adding the DMSO solution of Cur into DI water under continuous rapid stirring. The morphology of CFC NPs was a spherical shape with a diameter of 65.25 ± 2.09 nm (PDI = 0.229 ± 0.107), and the loading capacity (LC) of CFC NPs was as high as 96.68 ± 0.03%. The thermal property and crystallinity of CFC NPs were investigated by XRD. Furthermore, the CFC NPs significantly accelerated the release of Cur in vitro owing to its improved water dispersibility. Importantly, CFC NPs displayed significantly improved DPPH radical scavenging activity. Overall, all these results suggested that CFC NPs would be a promising vehicle to widen the applications of Cur in food fields. |
format | Online Article Text |
id | pubmed-9920916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99209162023-02-12 Fabrication, Evaluation, and Antioxidant Properties of Carrier-Free Curcumin Nanoparticles Wu, Jinwei Chen, Jiaxin Wei, Zizhan Zhu, Pingchuan Li, Bangda Qing, Qing Chen, Huimin Lin, Weiying Lin, Jianyan Hong, Xuehui Yu, Fei Chen, Xiaodong Molecules Communication Curcumin (Cur), a natural hydrophobic polyphenolic compound, exhibits multiple beneficial biological activities. However, low water solubility and relative instability hinder its application in food fields. In this study, carrier-free curcumin nanoparticles (CFC NPs) were prepared by adding the DMSO solution of Cur into DI water under continuous rapid stirring. The morphology of CFC NPs was a spherical shape with a diameter of 65.25 ± 2.09 nm (PDI = 0.229 ± 0.107), and the loading capacity (LC) of CFC NPs was as high as 96.68 ± 0.03%. The thermal property and crystallinity of CFC NPs were investigated by XRD. Furthermore, the CFC NPs significantly accelerated the release of Cur in vitro owing to its improved water dispersibility. Importantly, CFC NPs displayed significantly improved DPPH radical scavenging activity. Overall, all these results suggested that CFC NPs would be a promising vehicle to widen the applications of Cur in food fields. MDPI 2023-01-29 /pmc/articles/PMC9920916/ /pubmed/36770966 http://dx.doi.org/10.3390/molecules28031298 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Wu, Jinwei Chen, Jiaxin Wei, Zizhan Zhu, Pingchuan Li, Bangda Qing, Qing Chen, Huimin Lin, Weiying Lin, Jianyan Hong, Xuehui Yu, Fei Chen, Xiaodong Fabrication, Evaluation, and Antioxidant Properties of Carrier-Free Curcumin Nanoparticles |
title | Fabrication, Evaluation, and Antioxidant Properties of Carrier-Free Curcumin Nanoparticles |
title_full | Fabrication, Evaluation, and Antioxidant Properties of Carrier-Free Curcumin Nanoparticles |
title_fullStr | Fabrication, Evaluation, and Antioxidant Properties of Carrier-Free Curcumin Nanoparticles |
title_full_unstemmed | Fabrication, Evaluation, and Antioxidant Properties of Carrier-Free Curcumin Nanoparticles |
title_short | Fabrication, Evaluation, and Antioxidant Properties of Carrier-Free Curcumin Nanoparticles |
title_sort | fabrication, evaluation, and antioxidant properties of carrier-free curcumin nanoparticles |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920916/ https://www.ncbi.nlm.nih.gov/pubmed/36770966 http://dx.doi.org/10.3390/molecules28031298 |
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