Chloroquine-Based Mitochondrial ATP Inhibitors

Mitochondria is an important drug target for ailments ranging from neoplastic to neurodegenerative diseases and metabolic diseases. Here, we describe the synthesis of chloroquine analogs and show the results of mitochondrial ATP inhibition testing. The 2,4-dinitrobenzene-based analogs showed concent...

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Autores principales: Wang, Zhiguo, Sheaff, Robert J., Hussaini, Syed R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920964/
https://www.ncbi.nlm.nih.gov/pubmed/36770828
http://dx.doi.org/10.3390/molecules28031161
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author Wang, Zhiguo
Sheaff, Robert J.
Hussaini, Syed R.
author_facet Wang, Zhiguo
Sheaff, Robert J.
Hussaini, Syed R.
author_sort Wang, Zhiguo
collection PubMed
description Mitochondria is an important drug target for ailments ranging from neoplastic to neurodegenerative diseases and metabolic diseases. Here, we describe the synthesis of chloroquine analogs and show the results of mitochondrial ATP inhibition testing. The 2,4-dinitrobenzene-based analogs showed concentration-dependent mitochondrial (mito.) ATP inhibition. The most potent mito. ATP inhibitor was found to be N-(4-((2,4-Dinitrophenyl)amino)pentyl)-N-ethylacetamide (17).
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spelling pubmed-99209642023-02-12 Chloroquine-Based Mitochondrial ATP Inhibitors Wang, Zhiguo Sheaff, Robert J. Hussaini, Syed R. Molecules Article Mitochondria is an important drug target for ailments ranging from neoplastic to neurodegenerative diseases and metabolic diseases. Here, we describe the synthesis of chloroquine analogs and show the results of mitochondrial ATP inhibition testing. The 2,4-dinitrobenzene-based analogs showed concentration-dependent mitochondrial (mito.) ATP inhibition. The most potent mito. ATP inhibitor was found to be N-(4-((2,4-Dinitrophenyl)amino)pentyl)-N-ethylacetamide (17). MDPI 2023-01-24 /pmc/articles/PMC9920964/ /pubmed/36770828 http://dx.doi.org/10.3390/molecules28031161 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Zhiguo
Sheaff, Robert J.
Hussaini, Syed R.
Chloroquine-Based Mitochondrial ATP Inhibitors
title Chloroquine-Based Mitochondrial ATP Inhibitors
title_full Chloroquine-Based Mitochondrial ATP Inhibitors
title_fullStr Chloroquine-Based Mitochondrial ATP Inhibitors
title_full_unstemmed Chloroquine-Based Mitochondrial ATP Inhibitors
title_short Chloroquine-Based Mitochondrial ATP Inhibitors
title_sort chloroquine-based mitochondrial atp inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920964/
https://www.ncbi.nlm.nih.gov/pubmed/36770828
http://dx.doi.org/10.3390/molecules28031161
work_keys_str_mv AT wangzhiguo chloroquinebasedmitochondrialatpinhibitors
AT sheaffrobertj chloroquinebasedmitochondrialatpinhibitors
AT hussainisyedr chloroquinebasedmitochondrialatpinhibitors

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