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Unveiling the Efficacy of Sesquiterpenes from Marine Sponge Dactylospongia elegans in Inhibiting Dihydrofolate Reductase Using Docking and Molecular Dynamic Studies

Dihydrofolate reductase (DHFR) is a crucial enzyme that maintains the levels of 5,6,7,8-tetrahydrofolate (THF) required for the biological synthesis of the building blocks of DNA, RNA, and proteins. Over-activation of DHFR results in the progression of multiple pathological conditions such as cancer...

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Detalles Bibliográficos
Autores principales:	Omar, Abdelsattar M., Mohammad, Khadijah A., Sindi, Ikhlas A., Mohamed, Gamal A., Ibrahim, Sabrin R. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921107/ https://www.ncbi.nlm.nih.gov/pubmed/36770958 http://dx.doi.org/10.3390/molecules28031292

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