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Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis

Metastasis is a multi-step phenomenon during cancer development leading to the propagation of cancer cells to distant organ(s). According to estimations, metastasis results in over 90% of cancer-associated death around the globe. Long non-coding RNAs (LncRNAs) are a group of regulatory RNA molecules...

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Autores principales: Rajabi, Sadegh, Rajani, Huda Fatima, Mohammadkhani, Niloufar, Ramírez-Coronel, Andrés Alexis, Maleki, Mahsa, Maresca, Marc, Hajimehdipoor, Homa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921150/
https://www.ncbi.nlm.nih.gov/pubmed/36770654
http://dx.doi.org/10.3390/molecules28030987
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author Rajabi, Sadegh
Rajani, Huda Fatima
Mohammadkhani, Niloufar
Ramírez-Coronel, Andrés Alexis
Maleki, Mahsa
Maresca, Marc
Hajimehdipoor, Homa
author_facet Rajabi, Sadegh
Rajani, Huda Fatima
Mohammadkhani, Niloufar
Ramírez-Coronel, Andrés Alexis
Maleki, Mahsa
Maresca, Marc
Hajimehdipoor, Homa
author_sort Rajabi, Sadegh
collection PubMed
description Metastasis is a multi-step phenomenon during cancer development leading to the propagation of cancer cells to distant organ(s). According to estimations, metastasis results in over 90% of cancer-associated death around the globe. Long non-coding RNAs (LncRNAs) are a group of regulatory RNA molecules more than 200 base pairs in length. The main regulatory activity of these molecules is the modulation of gene expression. They have been reported to affect different stages of cancer development including proliferation, apoptosis, migration, invasion, and metastasis. An increasing number of medical data reports indicate the probable function of LncRNAs in the metastatic spread of different cancers. Phytochemical compounds, as the bioactive agents of plants, show several health benefits with a variety of biological activities. Several phytochemicals have been demonstrated to target LncRNAs to defeat cancer. This review article briefly describes the metastasis steps, summarizes data on some well-established LncRNAs with a role in metastasis, and identifies the phytochemicals with an ability to suppress cancer metastasis by targeting LncRNAs.
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spelling pubmed-99211502023-02-12 Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis Rajabi, Sadegh Rajani, Huda Fatima Mohammadkhani, Niloufar Ramírez-Coronel, Andrés Alexis Maleki, Mahsa Maresca, Marc Hajimehdipoor, Homa Molecules Review Metastasis is a multi-step phenomenon during cancer development leading to the propagation of cancer cells to distant organ(s). According to estimations, metastasis results in over 90% of cancer-associated death around the globe. Long non-coding RNAs (LncRNAs) are a group of regulatory RNA molecules more than 200 base pairs in length. The main regulatory activity of these molecules is the modulation of gene expression. They have been reported to affect different stages of cancer development including proliferation, apoptosis, migration, invasion, and metastasis. An increasing number of medical data reports indicate the probable function of LncRNAs in the metastatic spread of different cancers. Phytochemical compounds, as the bioactive agents of plants, show several health benefits with a variety of biological activities. Several phytochemicals have been demonstrated to target LncRNAs to defeat cancer. This review article briefly describes the metastasis steps, summarizes data on some well-established LncRNAs with a role in metastasis, and identifies the phytochemicals with an ability to suppress cancer metastasis by targeting LncRNAs. MDPI 2023-01-18 /pmc/articles/PMC9921150/ /pubmed/36770654 http://dx.doi.org/10.3390/molecules28030987 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rajabi, Sadegh
Rajani, Huda Fatima
Mohammadkhani, Niloufar
Ramírez-Coronel, Andrés Alexis
Maleki, Mahsa
Maresca, Marc
Hajimehdipoor, Homa
Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis
title Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis
title_full Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis
title_fullStr Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis
title_full_unstemmed Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis
title_short Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis
title_sort long non-coding rnas as novel targets for phytochemicals to cease cancer metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921150/
https://www.ncbi.nlm.nih.gov/pubmed/36770654
http://dx.doi.org/10.3390/molecules28030987
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