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Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis
Metastasis is a multi-step phenomenon during cancer development leading to the propagation of cancer cells to distant organ(s). According to estimations, metastasis results in over 90% of cancer-associated death around the globe. Long non-coding RNAs (LncRNAs) are a group of regulatory RNA molecules...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921150/ https://www.ncbi.nlm.nih.gov/pubmed/36770654 http://dx.doi.org/10.3390/molecules28030987 |
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author | Rajabi, Sadegh Rajani, Huda Fatima Mohammadkhani, Niloufar Ramírez-Coronel, Andrés Alexis Maleki, Mahsa Maresca, Marc Hajimehdipoor, Homa |
author_facet | Rajabi, Sadegh Rajani, Huda Fatima Mohammadkhani, Niloufar Ramírez-Coronel, Andrés Alexis Maleki, Mahsa Maresca, Marc Hajimehdipoor, Homa |
author_sort | Rajabi, Sadegh |
collection | PubMed |
description | Metastasis is a multi-step phenomenon during cancer development leading to the propagation of cancer cells to distant organ(s). According to estimations, metastasis results in over 90% of cancer-associated death around the globe. Long non-coding RNAs (LncRNAs) are a group of regulatory RNA molecules more than 200 base pairs in length. The main regulatory activity of these molecules is the modulation of gene expression. They have been reported to affect different stages of cancer development including proliferation, apoptosis, migration, invasion, and metastasis. An increasing number of medical data reports indicate the probable function of LncRNAs in the metastatic spread of different cancers. Phytochemical compounds, as the bioactive agents of plants, show several health benefits with a variety of biological activities. Several phytochemicals have been demonstrated to target LncRNAs to defeat cancer. This review article briefly describes the metastasis steps, summarizes data on some well-established LncRNAs with a role in metastasis, and identifies the phytochemicals with an ability to suppress cancer metastasis by targeting LncRNAs. |
format | Online Article Text |
id | pubmed-9921150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99211502023-02-12 Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis Rajabi, Sadegh Rajani, Huda Fatima Mohammadkhani, Niloufar Ramírez-Coronel, Andrés Alexis Maleki, Mahsa Maresca, Marc Hajimehdipoor, Homa Molecules Review Metastasis is a multi-step phenomenon during cancer development leading to the propagation of cancer cells to distant organ(s). According to estimations, metastasis results in over 90% of cancer-associated death around the globe. Long non-coding RNAs (LncRNAs) are a group of regulatory RNA molecules more than 200 base pairs in length. The main regulatory activity of these molecules is the modulation of gene expression. They have been reported to affect different stages of cancer development including proliferation, apoptosis, migration, invasion, and metastasis. An increasing number of medical data reports indicate the probable function of LncRNAs in the metastatic spread of different cancers. Phytochemical compounds, as the bioactive agents of plants, show several health benefits with a variety of biological activities. Several phytochemicals have been demonstrated to target LncRNAs to defeat cancer. This review article briefly describes the metastasis steps, summarizes data on some well-established LncRNAs with a role in metastasis, and identifies the phytochemicals with an ability to suppress cancer metastasis by targeting LncRNAs. MDPI 2023-01-18 /pmc/articles/PMC9921150/ /pubmed/36770654 http://dx.doi.org/10.3390/molecules28030987 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rajabi, Sadegh Rajani, Huda Fatima Mohammadkhani, Niloufar Ramírez-Coronel, Andrés Alexis Maleki, Mahsa Maresca, Marc Hajimehdipoor, Homa Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis |
title | Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis |
title_full | Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis |
title_fullStr | Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis |
title_full_unstemmed | Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis |
title_short | Long Non-Coding RNAs as Novel Targets for Phytochemicals to Cease Cancer Metastasis |
title_sort | long non-coding rnas as novel targets for phytochemicals to cease cancer metastasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921150/ https://www.ncbi.nlm.nih.gov/pubmed/36770654 http://dx.doi.org/10.3390/molecules28030987 |
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