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Differentiation of claustrum resting‐state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease

The claustrum is a sheet‐like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical areas as well as subcortical structures. Although the claustrum has been inv...

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Autores principales: Ayyildiz, Sevilay, Velioglu, Halil Aziz, Ayyildiz, Behcet, Sutcubasi, Bernis, Hanoglu, Lutfu, Bayraktaroglu, Zubeyir, Yildirim, Suleyman, Atasever, Alper, Yulug, Burak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921234/
https://www.ncbi.nlm.nih.gov/pubmed/36515182
http://dx.doi.org/10.1002/hbm.26171
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author Ayyildiz, Sevilay
Velioglu, Halil Aziz
Ayyildiz, Behcet
Sutcubasi, Bernis
Hanoglu, Lutfu
Bayraktaroglu, Zubeyir
Yildirim, Suleyman
Atasever, Alper
Yulug, Burak
author_facet Ayyildiz, Sevilay
Velioglu, Halil Aziz
Ayyildiz, Behcet
Sutcubasi, Bernis
Hanoglu, Lutfu
Bayraktaroglu, Zubeyir
Yildirim, Suleyman
Atasever, Alper
Yulug, Burak
author_sort Ayyildiz, Sevilay
collection PubMed
description The claustrum is a sheet‐like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical areas as well as subcortical structures. Although the claustrum has been involved in several neurodegenerative diseases, specific changes in connections of the claustrum remain unclear in Alzheimer's disease (AD), and Parkinson's disease (PD). Resting‐state fMRI and T1‐weighted structural 3D images from healthy elderly (n = 15), AD (n = 16), and PD (n = 12) subjects were analyzed. Seed‐based FC analysis was performed using CONN FC toolbox and T1‐weighted images were analyzed with the Computational Anatomy Toolbox for voxel‐based morphometry analysis. While we observed a decreased FC between the left claustrum and sensorimotor cortex, auditory association cortex, and cortical regions associated with social cognition in PD compared with the healthy control group (HC), no significant difference was found in alterations in the FC of both claustrum comparing the HC and AD groups. In the AD group, high FC of claustrum with regions of sensorimotor cortex and cortical regions related to cognitive control, including cingulate gyrus, supramarginal gyrus, and insular cortex were demonstrated. In addition, the structural results show significantly decreased volume in bilateral claustrum in AD and PD compared with HC. There were no significant differences in the claustrum volumes between PD and AD groups so the FC may offer more precise findings in distinguishing changes for claustrum in AD and PD.
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spelling pubmed-99212342023-02-13 Differentiation of claustrum resting‐state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease Ayyildiz, Sevilay Velioglu, Halil Aziz Ayyildiz, Behcet Sutcubasi, Bernis Hanoglu, Lutfu Bayraktaroglu, Zubeyir Yildirim, Suleyman Atasever, Alper Yulug, Burak Hum Brain Mapp Research Articles The claustrum is a sheet‐like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical areas as well as subcortical structures. Although the claustrum has been involved in several neurodegenerative diseases, specific changes in connections of the claustrum remain unclear in Alzheimer's disease (AD), and Parkinson's disease (PD). Resting‐state fMRI and T1‐weighted structural 3D images from healthy elderly (n = 15), AD (n = 16), and PD (n = 12) subjects were analyzed. Seed‐based FC analysis was performed using CONN FC toolbox and T1‐weighted images were analyzed with the Computational Anatomy Toolbox for voxel‐based morphometry analysis. While we observed a decreased FC between the left claustrum and sensorimotor cortex, auditory association cortex, and cortical regions associated with social cognition in PD compared with the healthy control group (HC), no significant difference was found in alterations in the FC of both claustrum comparing the HC and AD groups. In the AD group, high FC of claustrum with regions of sensorimotor cortex and cortical regions related to cognitive control, including cingulate gyrus, supramarginal gyrus, and insular cortex were demonstrated. In addition, the structural results show significantly decreased volume in bilateral claustrum in AD and PD compared with HC. There were no significant differences in the claustrum volumes between PD and AD groups so the FC may offer more precise findings in distinguishing changes for claustrum in AD and PD. John Wiley & Sons, Inc. 2022-12-14 /pmc/articles/PMC9921234/ /pubmed/36515182 http://dx.doi.org/10.1002/hbm.26171 Text en © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Ayyildiz, Sevilay
Velioglu, Halil Aziz
Ayyildiz, Behcet
Sutcubasi, Bernis
Hanoglu, Lutfu
Bayraktaroglu, Zubeyir
Yildirim, Suleyman
Atasever, Alper
Yulug, Burak
Differentiation of claustrum resting‐state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
title Differentiation of claustrum resting‐state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
title_full Differentiation of claustrum resting‐state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
title_fullStr Differentiation of claustrum resting‐state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
title_full_unstemmed Differentiation of claustrum resting‐state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
title_short Differentiation of claustrum resting‐state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
title_sort differentiation of claustrum resting‐state functional connectivity in healthy aging, alzheimer's disease, and parkinson's disease
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921234/
https://www.ncbi.nlm.nih.gov/pubmed/36515182
http://dx.doi.org/10.1002/hbm.26171
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