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Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis

Eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6), two omega-3 poly-unsaturated fatty acids (PUFAs), are the main components in oil derived from fish and other marine organisms. EPA and DHA are commercially available as dietary supplements and are considered to be very safe and...

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Autores principales: Ciccone, Lidia, Nencetti, Susanna, Rossello, Armando, Barlettani, Lucia, Tonali, Nicolò, Nieri, Paola, Orlandini, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921273/
https://www.ncbi.nlm.nih.gov/pubmed/36771455
http://dx.doi.org/10.3390/nu15030749
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author Ciccone, Lidia
Nencetti, Susanna
Rossello, Armando
Barlettani, Lucia
Tonali, Nicolò
Nieri, Paola
Orlandini, Elisabetta
author_facet Ciccone, Lidia
Nencetti, Susanna
Rossello, Armando
Barlettani, Lucia
Tonali, Nicolò
Nieri, Paola
Orlandini, Elisabetta
author_sort Ciccone, Lidia
collection PubMed
description Eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6), two omega-3 poly-unsaturated fatty acids (PUFAs), are the main components in oil derived from fish and other marine organisms. EPA and DHA are commercially available as dietary supplements and are considered to be very safe and contribute to guaranteeing human health. Studies report that PUFAs have a role in contrasting neurodegenerative processes related to amyloidogenic proteins, such as β-amyloid for AD, α-synuclein in PD, and transthyretin (TTR) in TTR amyloidosis. In this context, we investigated if EPA and DHA can interact directly with TTR, binding inside the thyroxin-binding pockets (T(4)BP) that contribute to the tetramer stabilization. The data obtained showed that EPA and DHA can contribute to stabilizing the TTR tetramer through interactions with T(4)BP.
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spelling pubmed-99212732023-02-12 Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis Ciccone, Lidia Nencetti, Susanna Rossello, Armando Barlettani, Lucia Tonali, Nicolò Nieri, Paola Orlandini, Elisabetta Nutrients Communication Eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6), two omega-3 poly-unsaturated fatty acids (PUFAs), are the main components in oil derived from fish and other marine organisms. EPA and DHA are commercially available as dietary supplements and are considered to be very safe and contribute to guaranteeing human health. Studies report that PUFAs have a role in contrasting neurodegenerative processes related to amyloidogenic proteins, such as β-amyloid for AD, α-synuclein in PD, and transthyretin (TTR) in TTR amyloidosis. In this context, we investigated if EPA and DHA can interact directly with TTR, binding inside the thyroxin-binding pockets (T(4)BP) that contribute to the tetramer stabilization. The data obtained showed that EPA and DHA can contribute to stabilizing the TTR tetramer through interactions with T(4)BP. MDPI 2023-02-01 /pmc/articles/PMC9921273/ /pubmed/36771455 http://dx.doi.org/10.3390/nu15030749 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ciccone, Lidia
Nencetti, Susanna
Rossello, Armando
Barlettani, Lucia
Tonali, Nicolò
Nieri, Paola
Orlandini, Elisabetta
Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis
title Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis
title_full Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis
title_fullStr Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis
title_full_unstemmed Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis
title_short Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis
title_sort omega-3 pufas as a dietary supplement in senile systemic amyloidosis
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921273/
https://www.ncbi.nlm.nih.gov/pubmed/36771455
http://dx.doi.org/10.3390/nu15030749
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