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Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid

Ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), and we previously showed that inactivation of OAT inhibits the growth of HCC. Recently, we found that (3S,4S)-3-amino-4-fluorocyclopentenecarboxylic acid (5) was a potent inactivator of γ-aminobutyric acid aminotran...

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Detalles Bibliográficos
Autores principales:	Shen, Sida, Butrin, Arseniy, Beaupre, Brett A., Ferreira, Glaucio M., Doubleday, Peter F., Grass, Daniel H., Zhu, Wei, Kelleher, Neil L., Moran, Graham R., Liu, Dali, Silverman, Richard B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921285/ https://www.ncbi.nlm.nih.gov/pubmed/36770800 http://dx.doi.org/10.3390/molecules28031133

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