Cellular senescence in the response of HR(+) breast cancer to radiotherapy and CDK4/6 inhibitors

BACKGROUND: Preclinical evidence from us and others demonstrates that the anticancer effects of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors can be enhanced with focal radiation therapy (RT), but only when RT is delivered prior to (rather than after) CDK4/6 inhibition. Depending on tumor model, c...

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Detalles Bibliográficos
Autores principales: Klapp, Vanessa, Buqué, Aitziber, Bloy, Norma, Sato, Ai, Yamazaki, Takahiro, Zhou, Xi Kathy, Formenti, Silvia C., Galluzzi, Lorenzo, Petroni, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921325/
https://www.ncbi.nlm.nih.gov/pubmed/36765430
http://dx.doi.org/10.1186/s12967-023-03964-4

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