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Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition
Alopecia and gray hair are common hair abnormalities affecting physical appearance and causing psychological problems. Chemical treatments partially restore hair disorders but have distressing side effects. Bioactive plant compounds constitute promising sources of potential medicinal substances inst...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921347/ https://www.ncbi.nlm.nih.gov/pubmed/36771737 http://dx.doi.org/10.3390/plants12030653 |
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author | Ruksiriwanich, Warintorn Linsaenkart, Pichchapa Khantham, Chiranan Muangsanguan, Anurak Sringarm, Korawan Jantrawut, Pensak Prom-u-thai, Chanakan Jamjod, Sansanee Yamuangmorn, Supapohn Arjin, Chaiwat Rachtanapun, Pornchai Jantanasakulwong, Kittisak Phimolsiripol, Yuthana Barba, Francisco J. Sommano, Sarana Rose Chutoprapat, Romchat Boonpisuttinant, Korawinwich |
author_facet | Ruksiriwanich, Warintorn Linsaenkart, Pichchapa Khantham, Chiranan Muangsanguan, Anurak Sringarm, Korawan Jantrawut, Pensak Prom-u-thai, Chanakan Jamjod, Sansanee Yamuangmorn, Supapohn Arjin, Chaiwat Rachtanapun, Pornchai Jantanasakulwong, Kittisak Phimolsiripol, Yuthana Barba, Francisco J. Sommano, Sarana Rose Chutoprapat, Romchat Boonpisuttinant, Korawinwich |
author_sort | Ruksiriwanich, Warintorn |
collection | PubMed |
description | Alopecia and gray hair are common hair abnormalities affecting physical appearance and causing psychological problems. Chemical treatments partially restore hair disorders but have distressing side effects. Bioactive plant compounds constitute promising sources of potential medicinal substances instead of chemical agents, producing high side effects. In this study, we focused on the waste of local rice cultivars: Bue Bang 3 CMU (BB3CMU) and Bue Bang 4 CMU (BB4CMU) from the north of Thailand. The rice bran oil (RBO), defatted rice bran extract (DFRB), and rice husk (H) were determined for in vitro hair revitalization in melanin production, nitric oxide (NO) secretion, and steroid 5α-reductase inhibition. The results indicated that BB4CMU-RBO with high contents of iron, zinc, and free fatty acids showed a comparable induction of melanin production on melanocytes (130.18 ± 9.13% of control) to the standard drug theophylline with no significant difference (p > 0.05). This promising melanin induction could be related to activating the NO secretion pathway, with the NO secretion level at 1.43 ± 0.05 µM. In addition, BB4CMU-RBO illustrated a significant inhibitory effect on both steroid 5α-reductase genes (SRD5A) type 1 and type 2, which relates to its primary source of tocopherols. Hence, rice bran oil from the Thai rice variety BB4CMU could be applied as a promising hair revitalizing candidate, from natural resources, to help promote hair growth and re-pigmentation effects. |
format | Online Article Text |
id | pubmed-9921347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99213472023-02-12 Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition Ruksiriwanich, Warintorn Linsaenkart, Pichchapa Khantham, Chiranan Muangsanguan, Anurak Sringarm, Korawan Jantrawut, Pensak Prom-u-thai, Chanakan Jamjod, Sansanee Yamuangmorn, Supapohn Arjin, Chaiwat Rachtanapun, Pornchai Jantanasakulwong, Kittisak Phimolsiripol, Yuthana Barba, Francisco J. Sommano, Sarana Rose Chutoprapat, Romchat Boonpisuttinant, Korawinwich Plants (Basel) Article Alopecia and gray hair are common hair abnormalities affecting physical appearance and causing psychological problems. Chemical treatments partially restore hair disorders but have distressing side effects. Bioactive plant compounds constitute promising sources of potential medicinal substances instead of chemical agents, producing high side effects. In this study, we focused on the waste of local rice cultivars: Bue Bang 3 CMU (BB3CMU) and Bue Bang 4 CMU (BB4CMU) from the north of Thailand. The rice bran oil (RBO), defatted rice bran extract (DFRB), and rice husk (H) were determined for in vitro hair revitalization in melanin production, nitric oxide (NO) secretion, and steroid 5α-reductase inhibition. The results indicated that BB4CMU-RBO with high contents of iron, zinc, and free fatty acids showed a comparable induction of melanin production on melanocytes (130.18 ± 9.13% of control) to the standard drug theophylline with no significant difference (p > 0.05). This promising melanin induction could be related to activating the NO secretion pathway, with the NO secretion level at 1.43 ± 0.05 µM. In addition, BB4CMU-RBO illustrated a significant inhibitory effect on both steroid 5α-reductase genes (SRD5A) type 1 and type 2, which relates to its primary source of tocopherols. Hence, rice bran oil from the Thai rice variety BB4CMU could be applied as a promising hair revitalizing candidate, from natural resources, to help promote hair growth and re-pigmentation effects. MDPI 2023-02-02 /pmc/articles/PMC9921347/ /pubmed/36771737 http://dx.doi.org/10.3390/plants12030653 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ruksiriwanich, Warintorn Linsaenkart, Pichchapa Khantham, Chiranan Muangsanguan, Anurak Sringarm, Korawan Jantrawut, Pensak Prom-u-thai, Chanakan Jamjod, Sansanee Yamuangmorn, Supapohn Arjin, Chaiwat Rachtanapun, Pornchai Jantanasakulwong, Kittisak Phimolsiripol, Yuthana Barba, Francisco J. Sommano, Sarana Rose Chutoprapat, Romchat Boonpisuttinant, Korawinwich Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition |
title | Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition |
title_full | Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition |
title_fullStr | Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition |
title_full_unstemmed | Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition |
title_short | Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition |
title_sort | regulatory effects of thai rice by-product extracts from oryza sativa l. cv. bue bang 3 cmu and bue bang 4 cmu on melanin production, nitric oxide secretion, and steroid 5α-reductase inhibition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921347/ https://www.ncbi.nlm.nih.gov/pubmed/36771737 http://dx.doi.org/10.3390/plants12030653 |
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