Effects of Substituents on the Photophysical/Photobiological Properties of Mono-Substituted Corroles

The trans-A(2)B-corrole series was prepared starting with 5-(pentafluorophenyl)dipyrromethene, which was then reacted with respective aryl-substituted aldehyde by Gryko synthesis. It was further characterized by HRMS and electrochemical methods. In addition, we investigated experimental photophysica...

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Detalles Bibliográficos
Autores principales: de Souza, Vitória Barbosa, da Rocha, Vinícius N., Piquini, Paulo Cesar, Chaves, Otávio Augusto, Iglesias, Bernardo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921392/
https://www.ncbi.nlm.nih.gov/pubmed/36771053
http://dx.doi.org/10.3390/molecules28031385
Descripción
Sumario:The trans-A(2)B-corrole series was prepared starting with 5-(pentafluorophenyl)dipyrromethene, which was then reacted with respective aryl-substituted aldehyde by Gryko synthesis. It was further characterized by HRMS and electrochemical methods. In addition, we investigated experimental photophysical properties (absorption, emission by steady-state and time-resolved fluorescence) in several solvents and TDDFT calculations, aggregation, photostability and reactive oxygen species generation (ROS), which are relevant when selecting photosensitizers used in photodynamic therapy and many other photo-applications. In addition, we also evaluated the biomolecule-binding properties with CT-DNA and HSA by spectroscopy, viscometry and molecular docking calculations assays.

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