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One-year outcomes of catheter ablation for atrial fibrillation in young patients
BACKGROUND: Atrial fibrillation (AF) is relatively less frequent in younger patients (age < 50). Recently, studies have suggested that early restoration of sinus rhythm may lead to improved outcomes compared with rate control, however the efficacy of catheter ablation for AF in young is scarce. M...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921413/ https://www.ncbi.nlm.nih.gov/pubmed/36774486 http://dx.doi.org/10.1186/s12872-022-03017-6 |
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author | Tseng, Andrew S. Patel, Harsh P. Kumar, Ashish Jani, Chinmay Patel, Kirtenkumar Jaswaney, Rahul Thakkar, Samarthkumar Kowlgi, Narayan G. Dani, Sourbha S. Arora, Shilpkumar Mulpuru, Siva K. Madhavan, Malini Killu, Ammar M. Cha, Yong-mei DeSimone, Christopher V. Deshmukh, Abhishek |
author_facet | Tseng, Andrew S. Patel, Harsh P. Kumar, Ashish Jani, Chinmay Patel, Kirtenkumar Jaswaney, Rahul Thakkar, Samarthkumar Kowlgi, Narayan G. Dani, Sourbha S. Arora, Shilpkumar Mulpuru, Siva K. Madhavan, Malini Killu, Ammar M. Cha, Yong-mei DeSimone, Christopher V. Deshmukh, Abhishek |
author_sort | Tseng, Andrew S. |
collection | PubMed |
description | BACKGROUND: Atrial fibrillation (AF) is relatively less frequent in younger patients (age < 50). Recently, studies have suggested that early restoration of sinus rhythm may lead to improved outcomes compared with rate control, however the efficacy of catheter ablation for AF in young is scarce. METHODS: We included all hospitalized patients between 18 and 50 years with a diagnosis of AF from the Nationwide Readmission Database 2016–2017 from the Healthcare Cost and Utilization Project. Demographic and comorbidity data were collected and analyzed. Outcomes assessed included one-year AF readmission rates, all-cause readmission, ischemic stroke, and all-cause mortality. Subgroup analyses were performed for all demographic and comorbidity variables. RESULTS: Overall, 52,598 patients (medium age 44, interquartile range 38–48, female 25.7%) were included in the study, including 2,146 (4.0%) who underwent catheter ablation for AF. Patients who underwent catheter ablation had a significantly lower rate of readmission for AF or any cause at one year (adjusted hazard ratios (HR) of 0.52 [95% confidence interval (CI): 0.43–0.63] and HR of 0.81 [95% CI: 0.72–0.89], respectively). There was no difference in 1-year readmission for stroke or all-cause mortality between the two groups. Subgroup analyses showed a consistent reduction in the risk of AF readmission among major demographic and comorbidity subgroups. CONCLUSION: Catheter ablation in young patients with AF was associated with a reduction in 1-year AF related and all-cause readmissions. These data merit further prospective investigation for validation, through dedicated registries and multicenter collaborations to include young AF from diverse population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-022-03017-6. |
format | Online Article Text |
id | pubmed-9921413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99214132023-02-12 One-year outcomes of catheter ablation for atrial fibrillation in young patients Tseng, Andrew S. Patel, Harsh P. Kumar, Ashish Jani, Chinmay Patel, Kirtenkumar Jaswaney, Rahul Thakkar, Samarthkumar Kowlgi, Narayan G. Dani, Sourbha S. Arora, Shilpkumar Mulpuru, Siva K. Madhavan, Malini Killu, Ammar M. Cha, Yong-mei DeSimone, Christopher V. Deshmukh, Abhishek BMC Cardiovasc Disord Research Article BACKGROUND: Atrial fibrillation (AF) is relatively less frequent in younger patients (age < 50). Recently, studies have suggested that early restoration of sinus rhythm may lead to improved outcomes compared with rate control, however the efficacy of catheter ablation for AF in young is scarce. METHODS: We included all hospitalized patients between 18 and 50 years with a diagnosis of AF from the Nationwide Readmission Database 2016–2017 from the Healthcare Cost and Utilization Project. Demographic and comorbidity data were collected and analyzed. Outcomes assessed included one-year AF readmission rates, all-cause readmission, ischemic stroke, and all-cause mortality. Subgroup analyses were performed for all demographic and comorbidity variables. RESULTS: Overall, 52,598 patients (medium age 44, interquartile range 38–48, female 25.7%) were included in the study, including 2,146 (4.0%) who underwent catheter ablation for AF. Patients who underwent catheter ablation had a significantly lower rate of readmission for AF or any cause at one year (adjusted hazard ratios (HR) of 0.52 [95% confidence interval (CI): 0.43–0.63] and HR of 0.81 [95% CI: 0.72–0.89], respectively). There was no difference in 1-year readmission for stroke or all-cause mortality between the two groups. Subgroup analyses showed a consistent reduction in the risk of AF readmission among major demographic and comorbidity subgroups. CONCLUSION: Catheter ablation in young patients with AF was associated with a reduction in 1-year AF related and all-cause readmissions. These data merit further prospective investigation for validation, through dedicated registries and multicenter collaborations to include young AF from diverse population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-022-03017-6. BioMed Central 2023-02-11 /pmc/articles/PMC9921413/ /pubmed/36774486 http://dx.doi.org/10.1186/s12872-022-03017-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Tseng, Andrew S. Patel, Harsh P. Kumar, Ashish Jani, Chinmay Patel, Kirtenkumar Jaswaney, Rahul Thakkar, Samarthkumar Kowlgi, Narayan G. Dani, Sourbha S. Arora, Shilpkumar Mulpuru, Siva K. Madhavan, Malini Killu, Ammar M. Cha, Yong-mei DeSimone, Christopher V. Deshmukh, Abhishek One-year outcomes of catheter ablation for atrial fibrillation in young patients |
title | One-year outcomes of catheter ablation for atrial fibrillation in young patients |
title_full | One-year outcomes of catheter ablation for atrial fibrillation in young patients |
title_fullStr | One-year outcomes of catheter ablation for atrial fibrillation in young patients |
title_full_unstemmed | One-year outcomes of catheter ablation for atrial fibrillation in young patients |
title_short | One-year outcomes of catheter ablation for atrial fibrillation in young patients |
title_sort | one-year outcomes of catheter ablation for atrial fibrillation in young patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921413/ https://www.ncbi.nlm.nih.gov/pubmed/36774486 http://dx.doi.org/10.1186/s12872-022-03017-6 |
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