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Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE)

BACKGROUND: The pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic lupus erythematosus (SLE). However, neuropsychiatric manifestations in this model have not been investigated in detail. Because neuropsychiatric lupus (NPSLE) is an important complication...

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Autores principales: Yun, Yang, Wang, Xuejiao, Xu, Jingyi, Jin, Chenye, Chen, Jingyu, Wang, Xueru, Wang, Jianing, Qin, Ling, Yang, Pingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921421/
https://www.ncbi.nlm.nih.gov/pubmed/36765366
http://dx.doi.org/10.1186/s12993-023-00205-y
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author Yun, Yang
Wang, Xuejiao
Xu, Jingyi
Jin, Chenye
Chen, Jingyu
Wang, Xueru
Wang, Jianing
Qin, Ling
Yang, Pingting
author_facet Yun, Yang
Wang, Xuejiao
Xu, Jingyi
Jin, Chenye
Chen, Jingyu
Wang, Xueru
Wang, Jianing
Qin, Ling
Yang, Pingting
author_sort Yun, Yang
collection PubMed
description BACKGROUND: The pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic lupus erythematosus (SLE). However, neuropsychiatric manifestations in this model have not been investigated in detail. Because neuropsychiatric lupus (NPSLE) is an important complication of SLE, we investigated the neuropsychiatric symptoms in the PIL mouse model to evaluate its suitability for NPSLE studies. RESULTS: PIL mice showed olfactory dysfunction accompanied by an anxiety- and depression-like phenotype at month 2 or 4 after pristane injection. The levels of cytokines (IL-1β, IFN-α, IFN-β, IL-10, IFN-γ, IL-6, TNF-α and IL-17A) and chemokines (CCL2 and CXCL10) in the brain and blood–brain barrier (BBB) permeability increased significantly from week 2 or month 1, and persisted throughout the observed course of the disease. Notably, IgG deposition in the choroid plexus and lateral ventricle wall were observed at month 1 and both astrocytes and microglia were activated. Persistent activation of astrocytes was detected throughout the observed course of the disease, while microglial activation diminished dramatically at month 4. Lipofuscin deposition, a sign of neuronal damage, was detected in cortical and hippocampal neurons from month 4 to 8. CONCLUSION: PIL mice exhibit a series of characteristic behavioral deficits and pathological changes in the brain, and therefore might be suitable for investigating disease pathogenesis and for evaluating potential therapeutic targets for environmental-related NPSLE. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12993-023-00205-y.
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spelling pubmed-99214212023-02-12 Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE) Yun, Yang Wang, Xuejiao Xu, Jingyi Jin, Chenye Chen, Jingyu Wang, Xueru Wang, Jianing Qin, Ling Yang, Pingting Behav Brain Funct Research BACKGROUND: The pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic lupus erythematosus (SLE). However, neuropsychiatric manifestations in this model have not been investigated in detail. Because neuropsychiatric lupus (NPSLE) is an important complication of SLE, we investigated the neuropsychiatric symptoms in the PIL mouse model to evaluate its suitability for NPSLE studies. RESULTS: PIL mice showed olfactory dysfunction accompanied by an anxiety- and depression-like phenotype at month 2 or 4 after pristane injection. The levels of cytokines (IL-1β, IFN-α, IFN-β, IL-10, IFN-γ, IL-6, TNF-α and IL-17A) and chemokines (CCL2 and CXCL10) in the brain and blood–brain barrier (BBB) permeability increased significantly from week 2 or month 1, and persisted throughout the observed course of the disease. Notably, IgG deposition in the choroid plexus and lateral ventricle wall were observed at month 1 and both astrocytes and microglia were activated. Persistent activation of astrocytes was detected throughout the observed course of the disease, while microglial activation diminished dramatically at month 4. Lipofuscin deposition, a sign of neuronal damage, was detected in cortical and hippocampal neurons from month 4 to 8. CONCLUSION: PIL mice exhibit a series of characteristic behavioral deficits and pathological changes in the brain, and therefore might be suitable for investigating disease pathogenesis and for evaluating potential therapeutic targets for environmental-related NPSLE. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12993-023-00205-y. BioMed Central 2023-02-10 /pmc/articles/PMC9921421/ /pubmed/36765366 http://dx.doi.org/10.1186/s12993-023-00205-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yun, Yang
Wang, Xuejiao
Xu, Jingyi
Jin, Chenye
Chen, Jingyu
Wang, Xueru
Wang, Jianing
Qin, Ling
Yang, Pingting
Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE)
title Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE)
title_full Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE)
title_fullStr Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE)
title_full_unstemmed Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE)
title_short Pristane induced lupus mice as a model for neuropsychiatric lupus (NPSLE)
title_sort pristane induced lupus mice as a model for neuropsychiatric lupus (npsle)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921421/
https://www.ncbi.nlm.nih.gov/pubmed/36765366
http://dx.doi.org/10.1186/s12993-023-00205-y
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