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The Effect of Alginate Concentration on Crystallinity, Morphology, and Thermal Stability Properties of Hydroxyapatite/Alginate Composite

Hydroxyapatite (HAp) has been used for various applications such as orthopedics, drug delivery material, and bone tissue engineering. It is well known that HAp has a good biocompatibility and osteoconductivity, so HAp can be used in biomedical applications. Hydroxyapatite can be combined with other...

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Autores principales: Wulandari, Wulandari, Islami, Dini Muthiah, Wellia, Diana Vanda, Emriadi, Emriadi, Sisca, Vivi, Jamarun, Novesar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921485/
https://www.ncbi.nlm.nih.gov/pubmed/36771915
http://dx.doi.org/10.3390/polym15030614
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author Wulandari, Wulandari
Islami, Dini Muthiah
Wellia, Diana Vanda
Emriadi, Emriadi
Sisca, Vivi
Jamarun, Novesar
author_facet Wulandari, Wulandari
Islami, Dini Muthiah
Wellia, Diana Vanda
Emriadi, Emriadi
Sisca, Vivi
Jamarun, Novesar
author_sort Wulandari, Wulandari
collection PubMed
description Hydroxyapatite (HAp) has been used for various applications such as orthopedics, drug delivery material, and bone tissue engineering. It is well known that HAp has a good biocompatibility and osteoconductivity, so HAp can be used in biomedical applications. Hydroxyapatite can be combined with other materials, in particular polymer, to expand its range of applications. In this study, the polymer that will be used as a support for the HAp composite is alginate (Alg). The HAp/Alg composite has been synthesized by the precipitation method. The XRD results show that the crystal system of HAp was hexagonal. The spheric-like shaped particles can be observed from SEM images, and particle size distribution spread from 400 to 1100 nm. The EDS spectrum exhibited the peak of Ca, C, P, and O elements, indicating that alginate had interacted with hydroxyapatite in the synthesized composite. The as-fabricated composite showed not only good crystallinity but also high thermal resistance. Thermogravimetric-differential thermal analysis (TGA-DTA) revealed that the HAp/Alg composites have a constant weight at 750 °C, so it might be applied in advanced applications such as bioimaging, drug carrier, and other cancer treatments.
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spelling pubmed-99214852023-02-12 The Effect of Alginate Concentration on Crystallinity, Morphology, and Thermal Stability Properties of Hydroxyapatite/Alginate Composite Wulandari, Wulandari Islami, Dini Muthiah Wellia, Diana Vanda Emriadi, Emriadi Sisca, Vivi Jamarun, Novesar Polymers (Basel) Article Hydroxyapatite (HAp) has been used for various applications such as orthopedics, drug delivery material, and bone tissue engineering. It is well known that HAp has a good biocompatibility and osteoconductivity, so HAp can be used in biomedical applications. Hydroxyapatite can be combined with other materials, in particular polymer, to expand its range of applications. In this study, the polymer that will be used as a support for the HAp composite is alginate (Alg). The HAp/Alg composite has been synthesized by the precipitation method. The XRD results show that the crystal system of HAp was hexagonal. The spheric-like shaped particles can be observed from SEM images, and particle size distribution spread from 400 to 1100 nm. The EDS spectrum exhibited the peak of Ca, C, P, and O elements, indicating that alginate had interacted with hydroxyapatite in the synthesized composite. The as-fabricated composite showed not only good crystallinity but also high thermal resistance. Thermogravimetric-differential thermal analysis (TGA-DTA) revealed that the HAp/Alg composites have a constant weight at 750 °C, so it might be applied in advanced applications such as bioimaging, drug carrier, and other cancer treatments. MDPI 2023-01-25 /pmc/articles/PMC9921485/ /pubmed/36771915 http://dx.doi.org/10.3390/polym15030614 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wulandari, Wulandari
Islami, Dini Muthiah
Wellia, Diana Vanda
Emriadi, Emriadi
Sisca, Vivi
Jamarun, Novesar
The Effect of Alginate Concentration on Crystallinity, Morphology, and Thermal Stability Properties of Hydroxyapatite/Alginate Composite
title The Effect of Alginate Concentration on Crystallinity, Morphology, and Thermal Stability Properties of Hydroxyapatite/Alginate Composite
title_full The Effect of Alginate Concentration on Crystallinity, Morphology, and Thermal Stability Properties of Hydroxyapatite/Alginate Composite
title_fullStr The Effect of Alginate Concentration on Crystallinity, Morphology, and Thermal Stability Properties of Hydroxyapatite/Alginate Composite
title_full_unstemmed The Effect of Alginate Concentration on Crystallinity, Morphology, and Thermal Stability Properties of Hydroxyapatite/Alginate Composite
title_short The Effect of Alginate Concentration on Crystallinity, Morphology, and Thermal Stability Properties of Hydroxyapatite/Alginate Composite
title_sort effect of alginate concentration on crystallinity, morphology, and thermal stability properties of hydroxyapatite/alginate composite
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921485/
https://www.ncbi.nlm.nih.gov/pubmed/36771915
http://dx.doi.org/10.3390/polym15030614
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