Elevation of Intracellular Alpha-Ketoglutarate Levels Inhibits Osteoclastogenesis by Suppressing the NF-κB Signaling Pathway in a PHD1-Dependent Manner

Age-related osteoporosis, a high-prevalence disease in the aged population, is generally attributed to the excessive activity of osteoclasts. Most approved drugs treat osteoporosis by inhibition of osteoclasts. Although in vivo studies have shown that alpha-ketoglutarate (AKG), an intermediate in th...

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Detalles Bibliográficos
Autores principales: Tian, Junquan, Bao, Xuetai, Yang, Fan, Tang, Xiongzhuo, Jiang, Qian, Li, Yuying, Yao, Kang, Yin, Yulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921543/
https://www.ncbi.nlm.nih.gov/pubmed/36771407
http://dx.doi.org/10.3390/nu15030701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921543/
https://www.ncbi.nlm.nih.gov/pubmed/36771407
http://dx.doi.org/10.3390/nu15030701

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